Literature DB >> 3523479

Odorant-binding protein: localization to nasal glands and secretions.

J Pevsner, P B Sklar, S H Snyder.   

Abstract

An odorant-binding protein (OBP) was isolated from bovine olfactory and respiratory mucosa. We have produced polyclonal antisera to this protein and report its immunohistochemical localization to mucus-secreting glands of the olfactory and respiratory mucosa. Although OBP was originally isolated as a pyrazine binding protein, both rat and bovine OBP also bind the odorants [3H]methyldihydrojasmonate and 3,7-dimethyl-octan-1-ol as well as 2-isobutyl-3-[3H]methoxypyrazine. We detect substantial odorant-binding activity attributable to OBP in secreted rat nasal mucus and tears but not in saliva, suggesting a role for OBP in transporting or concentrating odorants.

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Year:  1986        PMID： 3523479      PMCID： PMC323860          DOI： 10.1073/pnas.83.13.4942

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  26 in total

1.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

2.  Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors:  H Towbin; T Staehelin; J Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

Review 3.  Constituents of mucus and their separation.

Authors:  J M Creeth
Journal:  Br Med Bull       Date:  1978-01       Impact factor: 4.291

4.  Studies of the proteins of lacrimal secretions.

Authors:  A S Josephson; R S Weiner
Journal:  J Immunol       Date:  1968-05       Impact factor: 5.422

5.  The separation and characterization of proteins intrinsic to nasal secretion.

Authors:  R D Rossen; R H Alford; W T Butler; W E Vannier
Journal:  J Immunol       Date:  1966-09       Impact factor: 5.422

6.  Existence of a common precursor to ACTH and endorphin in the anterior and intermediate lobes of the rat pituitary.

Authors:  B A Eipper; R E Mains
Journal:  J Supramol Struct       Date:  1978

7.  Studies on the receptors to 5alpha-androst-16-en-3-one and 5alpha-androst-16-en-3alpha-ol in sow nasal mucosa.

Authors:  J N Gennings; D B Gower; L H Bannister
Journal:  Biochim Biophys Acta       Date:  1977-02-28

8.  alpha-Adrenergic regulation of secretion of mouse saliva rich in nerve growth factor.

Authors:  L J Wallace; L M Partlow
Journal:  Proc Natl Acad Sci U S A       Date:  1976-11       Impact factor: 11.205

9.  Nerve growth factor in mouse saliva. Rapid isolation procedures for and characterization of 7 S nerve growth factor.

Authors:  L E Burton; W H Wilson; E M Shooter
Journal:  J Biol Chem       Date:  1978-11-10       Impact factor: 5.157

10.  Evidence for a chromatographic model of olfaction.

Authors:  M M Mozell
Journal:  J Gen Physiol       Date:  1970-07       Impact factor: 4.086
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  20 in total

1.  Internalization of odorant-binding proteins into the mouse olfactory epithelium.

Authors:  Jörg Strotmann; Heinz Breer
Journal:  Histochem Cell Biol       Date:  2011-08-05       Impact factor: 4.304

2.  Olfaction by melanophores: what does it mean?

Authors:  M R Lerner; J Reagan; T Gyorgyi; A Roby
Journal:  Proc Natl Acad Sci U S A       Date:  1988-01       Impact factor: 11.205

3.  Membrane fluidity changes of liposomes in response to various odorants. Complexity of membrane composition and variety of adsorption sites for odorants.

Authors:  M Kashiwayanagi; A Suenaga; S Enomoto; K Kurihara
Journal:  Biophys J       Date:  1990-10       Impact factor: 4.033

4.  Spatial variation in response to odorants on the rat olfactory epithelium.

Authors:  D A Edwards; R A Mather; G H Dodd
Journal:  Experientia       Date:  1988-03-15

5.  Odorant-binding protein and its mRNA are localized to lateral nasal gland implying a carrier function.

Authors:  J Pevsner; P M Hwang; P B Sklar; J C Venable; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1988-04       Impact factor: 11.205

Review 6.  Gas sensors based on mass-sensitive transducers. Part 2: Improving the sensors towards practical application.

Authors:  Alexandru Oprea; Udo Weimar
Journal:  Anal Bioanal Chem       Date:  2020-07-31       Impact factor: 4.142

7.  Characterization and cDNA cloning of the pheromone-binding protein from the tobacco hornworm, Manduca sexta: a tissue-specific developmentally regulated protein.

Authors:  T K Györgyi; A J Roby-Shemkovitz; M R Lerner
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

8.  Odorant stimulation of secretory and neural processes in the salamander olfactory mucosa.

Authors:  M L Getchell; B Zielinski; J A DeSimone; T V Getchell
Journal:  J Comp Physiol A       Date:  1987-02       Impact factor: 1.836

9.  Glutathione S-transferases in rat olfactory epithelium: purification, molecular properties and odorant biotransformation.

Authors:  N Ben-Arie; M Khen; D Lancet
Journal:  Biochem J       Date:  1993-06-01       Impact factor: 3.857

10.  Novel genes for potential ligand-binding proteins in subregions of the olfactory mucosa.

Authors:  T N Dear; T Boehm; E B Keverne; T H Rabbitts
Journal:  EMBO J       Date:  1991-10       Impact factor: 11.598
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