Literature DB >> 35232299

Recruiting an underserved, difficult to reach population into a cancer trial: Strategies from the Restore-2 Rehabilitation Trial for gay and bisexual prostate cancer patients.

B R Simon Rosser1, Morgan Wright1, Chris J Hoefer1, Elizabeth J Polter1, Nidhi Kohli2, Christopher W Wheldon3, Ryan Haggart4, Kristine Mc Talley5, Darryl Mitteldorf6, Gunna Kilian1, Badrinath R Konety7, Michael W Ross8, William West9.   

Abstract

BACKGROUND/AIMS: Sexual minorities are small and under-researched populations that are at disproportionate risk for cancer and poor cancer outcomes. Described as a "hidden population," the principal research challenge has been to develop effective methods to identify and recruit such cancer patients into cancer studies. Online recruitment strategies, as well as targeted clinic recruitment using patient-entered sexual orientation and gender identity data from electronic medical records have potential to transform recruitment, but studies testing the effects of how to recruit using these have not been published.
METHODS: In 2019, we conducted a naturalistic, three-arm, stratified prospective study to compare three recruitment strategies: (a) clinic based recruitment of prostate cancer patients from gay health and urology clinics; (b) directly from the gay community; and (c) online recruitment (through cancer support, sex/dating, and social sites). For each strategy, we estimated time, workload, and direct costs involved. To study how recruitment strategy may affect sampling, we tested for retention rates, demographic and outcome differences across sites. Using these methods, we successfully recruited 401 gay and bisexual prostate cancer patients into a randomized, controlled, 24-month trial testing an online sexual and urinary rehabilitation curriculum tailored for this population.
RESULTS: There were seven key results. First, it is possible to recruit substantial numbers of sexual minority men into prostate cancer studies provided online recruitment methods are used. Second, we observed big differences in dropout during study onboarding by recruitment source. Third, within online recruitment, the online sex/dating application (app) was the most successful and efficient, followed by the cancer support site, and then the social networking site. Fourth, while clinics were the cheapest source of recruitment, they were time intensive and low in yield. Fifth, the cancer support site and sex/dating app recruits differed by several characteristics, with the former being more rehabilitation-focused while the latter were younger and more sexually active. Sixth, we found almost no differences in outcomes across the three online recruitment sites. Seventh, because retention in online studies has been a concern, we confirm very low attrition at 3- and 6 months into the trial.
CONCLUSION: For sexual minority cancer research, more research on how to use sexual orientation and gender identity electronic medical record data for clinic-based recruitment is needed. For other small or hard-to-reach populations, researchers should compare and publish online versus offline recruitment strategies.

Entities:  

Keywords:  Hidden populations; bisexual; clinic recruitment; gay; gay community recruitment; online recruitment; recruitment cost; recruitment effort; sexual minority

Mesh:

Year:  2022        PMID: 35232299      PMCID: PMC9232867          DOI: 10.1177/17407745221077678

Source DB:  PubMed          Journal:  Clin Trials        ISSN: 1740-7745            Impact factor:   2.599


  52 in total

1.  Lesbian, Gay, Bisexual, and Transgender Patient Care: Medical Students' Preparedness and Comfort.

Authors:  William White; Stephanie Brenman; Elise Paradis; Elizabeth S Goldsmith; Mitchell R Lunn; Juno Obedin-Maliver; Leslie Stewart; Eric Tran; Maggie Wells; Lisa J Chamberlain; David M Fetterman; Gabriel Garcia
Journal:  Teach Learn Med       Date:  2015       Impact factor: 2.414

Review 2.  Cancer and lesbian, gay, bisexual, transgender/transsexual, and queer/questioning (LGBTQ) populations.

Authors:  Gwendolyn P Quinn; Julian A Sanchez; Steven K Sutton; Susan T Vadaparampil; Giang T Nguyen; B Lee Green; Peter A Kanetsky; Matthew B Schabath
Journal:  CA Cancer J Clin       Date:  2015-07-17       Impact factor: 508.702

3.  Disparities in psychological distress impacting lesbian, gay, bisexual and transgender cancer survivors.

Authors:  Charles Kamen; Karen M Mustian; Ann Dozier; Deborah J Bowen; Yue Li
Journal:  Psychooncology       Date:  2015-01-28       Impact factor: 3.894

4.  Risk of breast cancer mortality among women cohabiting with same sex partners: findings from the National Health Interview Survey, 1997-2003.

Authors:  Susan D Cochran; Vickie M Mays
Journal:  J Womens Health (Larchmt)       Date:  2012-02-23       Impact factor: 2.681

5.  Comparison of lesbian and heterosexual women's response to newly diagnosed breast cancer.

Authors:  P Fobair; K O'Hanlan; C Koopman; C Classen; S Dimiceli; N Drooker; D Warner; H Davids; J Loulan; D Wallsten; D Goffinet; G Morrow; D Spiegel
Journal:  Psychooncology       Date:  2001 Jan-Feb       Impact factor: 3.894

6.  HIV sexual risk behavior by men who use the Internet to seek sex with men: results of the Men's INTernet Sex Study-II (MINTS-II).

Authors:  B R Simon Rosser; J Michael Oakes; Keith J Horvath; Joseph A Konstan; Gene P Danilenko; John L Peterson
Journal:  AIDS Behav       Date:  2009-02-10

7.  An ecological approach to examine lung cancer disparities due to sexual orientation.

Authors:  U Boehmer; A Ozonoff; X Miao
Journal:  Public Health       Date:  2012-05-11       Impact factor: 2.427

8.  Sexual rehabilitation after localized prostate cancer: current interventions and future directions.

Authors:  David M Latini; Stacey L Hart; David W Coon; Sara J Knight
Journal:  Cancer J       Date:  2009 Jan-Feb       Impact factor: 3.360

Review 9.  Cancer Screening and Prevention in Lesbian, Gay, Bisexual, and Transgendered Community and Asian Lesbian, Gay, Bisexual, and Transgendered Members.

Authors:  Carolee Polek; Thomas Hardie
Journal:  Asia Pac J Oncol Nurs       Date:  2019-12-10

10.  Internal Medicine Resident Attitudes, Prior Education, Comfort, and Knowledge Regarding Delivering Comprehensive Primary Care to Transgender Patients.

Authors:  Carrie D Johnston; Lee S Shearer
Journal:  Transgend Health       Date:  2017-07-01
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