New functions of CIPK gene family are continue to emerging.

CIPK protein family is a key protein family in Ca2+ mediated plant signaling pathway, which plays an indispensable role in plant response to stress and development. Every gene in this family encodes specific proteins. They interact with calcium ion signals, make plants to deal with various stress or stimuli. This article mainly reviews the mechanism, positioning and physiological functions of the CIPK family in different species in recent years. According to our team's research, CIPK8 interacts with CBL5 to improve salt tolerance, and CIPK23 interacts with TGA1 to regulate nitrate uptake negatively in chrysanthemum. In addition, we discussed current limitations and future research directions. The article will enhance the understanding of the functional characteristics of the CIPK gene family under different stresses, provide insights for future breeding and the development of new crop varieties with enhanced stress tolerance.