Literature DB >> 35228750

Beating cancer one carbon at a time.

Vasilis S Dionellis1, Thanos D Halazonetis2.   

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Year:  2022        PMID： 35228750     DOI： 10.1038/s43018-022-00333-w

Source DB:  PubMed          Journal:  Nat Cancer        ISSN： 2662-1347


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  12 in total

1.  Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase.

Authors:  A Schmidt; H Wu; R E MacKenzie; V J Chen; J R Bewly; J E Ray; J E Toth; M Cygler
Journal:  Biochemistry       Date:  2000-05-30       Impact factor: 3.162

Review 2.  One-Carbon Metabolism in Health and Disease.

Authors:  Gregory S Ducker; Joshua D Rabinowitz
Journal:  Cell Metab       Date:  2016-09-15       Impact factor: 27.287

3.  Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor.

Authors:  Robert Gustafsson; Ann-Sofie Jemth; Nina M S Gustafsson; Katarina Färnegårdh; Olga Loseva; Elisée Wiita; Nadilly Bonagas; Leif Dahllund; Sabin Llona-Minguez; Maria Häggblad; Martin Henriksson; Yasmin Andersson; Evert Homan; Thomas Helleday; Pål Stenmark
Journal:  Cancer Res       Date:  2016-11-29       Impact factor: 12.701

4.  Acinetobacter baumannii FolD ligand complexes --potent inhibitors of folate metabolism and a re-evaluation of the structure of LY374571.

Authors:  Thomas C Eadsforth; Fernando V Maluf; William N Hunter
Journal:  FEBS J       Date:  2012-11-05       Impact factor: 5.542

5.  Synthesis of pseudo cofactor analogues as potential inhibitors of the folate enzymes.

Authors:  C Temple; L L Bennett; J D Rose; R D Elliott; J A Montgomery; J H Mangum
Journal:  J Med Chem       Date:  1982-02       Impact factor: 7.446

6.  The antiproliferative and cell cycle effects of 5,6,7, 8-tetrahydro-N5,N10-carbonylfolic acid, an inhibitor of methylenetetrahydrofolate dehydrogenase, are potentiated by hypoxanthine.

Authors:  J L Tonkinson; L L Habeck; J E Toth; L G Mendelsohn; J Bewley; K A Shackelford; S B Gates; J Ray; V J Chen
Journal:  J Pharmacol Exp Ther       Date:  1998-10       Impact factor: 4.030

7.  Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway.

Authors:  Gregory S Ducker; Li Chen; Raphael J Morscher; Jonathan M Ghergurovich; Mark Esposito; Xin Teng; Yibin Kang; Joshua D Rabinowitz
Journal:  Cell Metab       Date:  2016-05-19       Impact factor: 27.287

Review 8.  Therapeutic targeting of the mitochondrial one-carbon pathway: perspectives, pitfalls, and potential.

Authors:  Li Na Zhao; Mikael Björklund; Matias J Caldez; Jie Zheng; Philipp Kaldis
Journal:  Oncogene       Date:  2021-03-04       Impact factor: 8.756

9.  Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer.

Authors:  Roland Nilsson; Mohit Jain; Nikhil Madhusudhan; Nina Gustafsson Sheppard; Laura Strittmatter; Caroline Kampf; Jenny Huang; Anna Asplund; Vamsi K Mootha
Journal:  Nat Commun       Date:  2014       Impact factor: 14.919

10.  Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications.

Authors:  Huai-Qiang Ju; Yun-Xin Lu; Dong-Liang Chen; Zhi-Xiang Zuo; Ze-Xian Liu; Qi-Nian Wu; Hai-Yu Mo; Zi-Xian Wang; De-Shen Wang; Heng-Ying Pu; Zhao-Lei Zeng; Bo Li; Dan Xie; Peng Huang; Mien-Chie Hung; Paul J Chiao; Rui-Hua Xu
Journal:  J Natl Cancer Inst       Date:  2019-06-01       Impact factor: 13.506
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