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Literature DB >> 3522636

Demonstration of carcinoembryonic antigen (CEA) expression in normal, chronically inflamed, and malignant pancreatic tissue by immunohistochemistry.

W H Allum, H J Stokes, F Macdonald, J W Fielding.

Abstract

The expression of carcinoembryonic antigen (CEA) was evaluated by immunoperoxidase staining with two anti-CEA monoclonal antibodies in normal, chronically inflamed, and malignant pancreatic tissue. Positive staining was not observed in normal specimens. In pancreatic cancer the expression of CEA was related to the degree of differentiation of the tumour. Positive staining was also observed in chronic pancreatitis.

Entities: Disease Gene

Mesh：

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Year: 1986 PMID： 3522636 PMCID： PMC499967 DOI： 10.1136/jcp.39.6.610

Source DB: PubMed Journal: J Clin Pathol ISSN： 0021-9746 Impact factor: 3.411

15 in total

1. Continuous cultures of fused cells secreting antibody of predefined specificity.

Authors: G Köhler; C Milstein
Journal: Nature Date: 1975-08-07 Impact factor: 49.962

Review 2. Tumor markers in pancreatic cancer.

Authors: E D Holyoke; H O Douglass; M H Goldrosen; T M Chu
Journal: Semin Oncol Date: 1979-09 Impact factor: 4.929

3. Immunocytochemical detection of carcinoembryonic antigen in conventional histopathology specimens.

Authors: D M Goldenberg; R M Sharkey; F J Primus
Journal: Cancer Date: 1978-09 Impact factor: 6.860

4. New oncofetal antigen for human pancreas.

Authors: O Banwo; J Versey; J R Hobbs
Journal: Lancet Date: 1974-04 Impact factor: 79.321

5. Immunologic diagnosis and prognosis of human digestive-tract cancer: carcinoembryonic antigens.

Authors: N Zamcheck; T L Moore; P Dhar; H Kupchik
Journal: N Engl J Med Date: 1972-01-13 Impact factor: 91.245

6. Carcinoembryonic antigen in pancreatitis.

Authors: R Delwiche; N Zamcheck; N Marcon
Journal: Cancer Date: 1973-02 Impact factor: 6.860

7. Radioimmunodetection of cancer with radioactive antibodies to carcinoembryonic antigen.

Authors: D M Goldenberg; E E Kim; F H DeLand; S Bennett; F J Primus
Journal: Cancer Res Date: 1980-08 Impact factor: 12.701

8. Immunohistochemical observations of carcinoembryonic antigen (CEA) and CEA-related substances in normal and neoplastic pancreas. Pitfalls and caveats in CEA immunohistochemistry.

Authors: Y Tsutsumi; H Nagura; K Watanabe
Journal: Am J Clin Pathol Date: 1984-11 Impact factor: 2.493

9. Carcinoembryonic antigen (CEA) in gastrointestinal and extragastrointestinal tumors and its relationship to tumor-cell differentiation.

Authors: H Denk; G Tappeiner; R Eckerstorfer; J H Holzner
Journal: Int J Cancer Date: 1972-09-15 Impact factor: 7.396

10. Tumor localization of radiolabeled antibodies against carcinoembryonic antigen in patients with carcinoma: a critical evaluation.

Authors: J P Mach; S Carrel; M Forni; J Ritschard; A Donath; P Alberto
Journal: N Engl J Med Date: 1980-07-03 Impact factor: 91.245

20 in total

Demonstration of carcinoembryonic antigen (CEA) expression in normal, chronically inflamed, and malignant pancreatic tissue by immunohistochemistry.

1. Continuous cultures of fused cells secreting antibody of predefined specificity.

Review 2. Tumor markers in pancreatic cancer.

3. Immunocytochemical detection of carcinoembryonic antigen in conventional histopathology specimens.

4. New oncofetal antigen for human pancreas.

5. Immunologic diagnosis and prognosis of human digestive-tract cancer: carcinoembryonic antigens.

6. Carcinoembryonic antigen in pancreatitis.

7. Radioimmunodetection of cancer with radioactive antibodies to carcinoembryonic antigen.

8. Immunohistochemical observations of carcinoembryonic antigen (CEA) and CEA-related substances in normal and neoplastic pancreas. Pitfalls and caveats in CEA immunohistochemistry.

9. Carcinoembryonic antigen (CEA) in gastrointestinal and extragastrointestinal tumors and its relationship to tumor-cell differentiation.

10. Tumor localization of radiolabeled antibodies against carcinoembryonic antigen in patients with carcinoma: a critical evaluation.

Review 1. Advances in biomarker research for pancreatic cancer.

Review 2. CAR T-cell therapy for pancreatic cancer.

3. Monoclonal antibody to a human pancreatic carcinoma cell line recognizes gastrointestinal neoplasms.

4. Epithelial markers in pancreatic carcinoma: immunoperoxidase localisation of DD9, CEA, EMA and CAM 5.2.

Review 5. Chimeric antigen receptor T cell therapy in pancreatic cancer: from research to practice.

6. Expression of CEA, CA125, CA19-9 and human milk fat globule membrane antigen in ovarian tumours.

7. Expression of the cell surface antigen detected by the monoclonal antibody A7 in pancreatic carcinoma cell lines.

8. In vivo studies on the uptake of radiolabelled antibodies by colorectal and gastric carcinoma xenografts.

9. Tumour immunogenicity, antigen presentation and immunological barriers in cancer immunotherapy.

10. Targeting CEA in Pancreas Cancer Xenografts with a Mutated scFv-Fc Antibody Fragment.