Literature DB >> 35224682

How does treadmill training contribute to botulinum toxin application plus routine physical therapy in ambulatory children with spastic bilateral cerebral palsy? A randomized controlled trial.

Kübra Seyhan Bıyık1, Mintaze Kerem Günel2, Ece Ünlü Akyüz3.   

Abstract

BACKGROUND: In spite of treadmill training and multilevel botulinum toxin (BoNT-A) injection being the two most commonly used treatment methods in pediatric rehabilitation management, there was no study investigating the effect of treadmill training after BoNT-A injection in children with cerebral palsy (CP). AIM: The aim of this study was to investigate the effect of treadmill training in addition to routine physical therapy after BoNT-A injection in ambulatory children with spastic bilateral CP on lower extremity muscle strength, selective motor control, and mobility.
METHODS: A total of 30 spastic bilateral children with CP classified level II-III by the Gross Motor Function Classification System were randomly assigned the study and control groups. Both groups continued routine physical therapy treatments after multilevel BoNT-A injection into lower extremities, while the study group additionally underwent 8 weeks of treadmill training (20 min, two sessions per week). Handheld dynamometer, selective control assessment of lower extremity, temporospatial evaluation of gait, and Pediatric Evaluation of Disability Inventory were assessed before and after 8 weeks.
RESULTS: In both groups, hip, knee, and ankle muscle strength increased at the end of 8 weeks (p < 0.05); however, in the study group, hip flexor/extensor muscle strength (p < 0.05, ES ≥ 0.50), selective motor control of ankle (p < 0.01, ES = 1.17), walking speed (p < 0.01, ES = 2.60), step lengths (p < 0.01, ES = 1.32), and mobility (p < 0.01, ES = 1.37) increased significantly compared to those of the control group.
CONCLUSIONS: Treadmill training in addition to routine physical therapy after BoNT-A injection is beneficial for hip muscle strength, ankle selective motor control, walking quality, and functional mobility in the short term. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT03580174.
© 2022. The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland.

Entities:  

Keywords:  Activity; Botulinum toxin; Function; Selective motor control; Treadmill

Year:  2022        PMID: 35224682     DOI: 10.1007/s11845-022-02960-9

Source DB:  PubMed          Journal:  Ir J Med Sci        ISSN: 0021-1265            Impact factor:   1.568


  18 in total

1.  Effects of intensive locomotor treadmill training on young children with cerebral palsy.

Authors:  Katrin Mattern-Baxter; Sandra Bellamy; Jim K Mansoor
Journal:  Pediatr Phys Ther       Date:  2009       Impact factor: 3.049

2.  Construct validity and reliability of the Selective Control Assessment of the Lower Extremity in children with cerebral palsy.

Authors:  Julia Balzer; Petra Marsico; Elena Mitteregger; Marietta L van der Linden; Thomas H Mercer; Hubertus J A van Hedel
Journal:  Dev Med Child Neurol       Date:  2015-05-20       Impact factor: 5.449

Review 3.  The efficacy of functional gait training in children and young adults with cerebral palsy: a systematic review and meta-analysis.

Authors:  Adam T C Booth; Annemieke I Buizer; Pieter Meyns; Irene L B Oude Lansink; Frans Steenbrink; Marjolein M van der Krogt
Journal:  Dev Med Child Neurol       Date:  2018-03-07       Impact factor: 5.449

4.  A report: the definition and classification of cerebral palsy April 2006.

Authors:  Peter Rosenbaum; Nigel Paneth; Alan Leviton; Murray Goldstein; Martin Bax; Diane Damiano; Bernard Dan; Bo Jacobsson
Journal:  Dev Med Child Neurol Suppl       Date:  2007-02

5.  Intensive therapy following upper limb botulinum toxin A injection in young children with unilateral cerebral palsy: a randomized trial.

Authors:  Brian Hoare; Christine Imms; Elmer Villanueva; Hyam Barry Rawicki; Thomas Matyas; Leeanne Carey
Journal:  Dev Med Child Neurol       Date:  2012-12-12       Impact factor: 5.449

6.  Efficacy of gait trainer as an adjunct to traditional physical therapy on walking performance in hemiparetic cerebral palsied children: a randomized controlled trial.

Authors:  Nevein Mm Gharib; Gehan M Abd El-Maksoud; Soheir S Rezk-Allah
Journal:  Clin Rehabil       Date:  2011-03-22       Impact factor: 3.477

7.  Reliability of hand-held dynamometry and functional strength tests for the lower extremity in children with Cerebral Palsy.

Authors:  Olaf Verschuren; Marjolijn Ketelaar; Tim Takken; Marco Van Brussel; Paul J M Helders; Jan Willem Gorter
Journal:  Disabil Rehabil       Date:  2008       Impact factor: 3.033

8.  Validity and reliability of the Turkish translation of the Pediatric Evaluation of Disability Inventory (PEDI).

Authors:  Gulten Erkin; Atilla H Elhan; Canan Aybay; Hulya Sirzai; Sumru Ozel
Journal:  Disabil Rehabil       Date:  2007-08-30       Impact factor: 3.033

9.  Intramuscular botulinum toxin prior to comprehensive rehabilitation has no added value for improving motor impairments, gait kinematics and goal attainment in walking children with spastic cerebral palsy.

Authors:  Fabienne Schasfoort; Robert Pangalila; Emiel M Sneekes; Coriene Catsman; Jules Becher; Herwin Horemans; Henk J Stam; Annet J Dallmeijer; Johannes B J Bussmann
Journal:  J Rehabil Med       Date:  2018-08-22       Impact factor: 2.912

Review 10.  Molecular mechanisms of treadmill therapy on neuromuscular atrophy induced via botulinum toxin A.

Authors:  Sen-Wei Tsai; Hsiao-Ling Chen; Yi-Chun Chang; Chuan-Mu Chen
Journal:  Neural Plast       Date:  2013-11-12       Impact factor: 3.599

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