Literature DB >> 3522073

Abnormal respiratory epithelial ion transport in cystic fibrosis.

M R Knowles, M J Stutts, J R Yankaskas, J T Gatzy, R C Boucher.   

Abstract

The respiratory epithelium of cystic fibrosis patients exhibits excessive sodium (and volume) absorption and an absence of chloride (and volume) secretion in response to usual stimuli. These abnormalities likely contribute to the pathophysiology of cystic fibrosis lung disease, and provide a rationale for a novel therapeutic approach to this problem.

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Year:  1986        PMID： 3522073

Source DB:  PubMed          Journal:  Clin Chest Med        ISSN： 0272-5231            Impact factor:   2.878


  15 in total

Review 1.  The biochemical defect in cystic fibrosis.

Authors:  A W Cuthbert
Journal:  J R Soc Med       Date:  1992       Impact factor: 5.344

Review 2.  ENaCs and ASICs as therapeutic targets.

Authors:  Yawar J Qadri; Arun K Rooj; Catherine M Fuller
Journal:  Am J Physiol Cell Physiol       Date:  2012-01-25       Impact factor: 4.249

3.  In vitro activity of amiloride combined with tobramycin against Pseudomonas isolates from patients with cystic fibrosis.

Authors:  R C Cohn; M Jacobs; S C Aronoff
Journal:  Antimicrob Agents Chemother       Date:  1988-03       Impact factor: 5.191

4.  Cystic fibrosis: after the gene.

Authors:  A Harris; M Borrow
Journal:  J Med Genet       Date:  1989-12       Impact factor: 6.318

5.  Fluid and electrolyte transport by cultured human airway epithelia.

Authors:  J J Smith; M J Welsh
Journal:  J Clin Invest       Date:  1993-04       Impact factor: 14.808

6.  Structure of two sulphated oligosaccharides from respiratory mucins of a patient suffering from cystic fibrosis. A fast-atom-bombardment m.s. and 1H-n.m.r. spectroscopic study.

Authors:  G Lamblin; H Rahmoune; J M Wieruszeski; M Lhermitte; G Strecker; P Roussel
Journal:  Biochem J       Date:  1991-04-01       Impact factor: 3.857

7.  A multiple reader scoring system for Nasal Potential Difference parameters.

Authors:  George M Solomon; Bo Liu; Isabelle Sermet-Gaudelus; Isabelle Fajac; Michael Wilschanski; Francois Vermeulen; Steven M Rowe
Journal:  J Cyst Fibros       Date:  2017-04-29       Impact factor: 5.482

8.  Enhanced Ca2+ entry due to Orai1 plasma membrane insertion increases IL-8 secretion by cystic fibrosis airways.

Authors:  Haouaria Balghi; Renaud Robert; Benjamin Rappaz; Xuexin Zhang; Adeline Wohlhuter-Haddad; Alexandra Evagelidis; Yishan Luo; Julie Goepp; Pasquale Ferraro; Philippe Roméo; Mohamed Trebak; Paul W Wiseman; David Y Thomas; John W Hanrahan
Journal:  FASEB J       Date:  2011-08-26       Impact factor: 5.191

9.  Intracellular pH and its relationship to regulation of ion transport in normal and cystic fibrosis human nasal epithelia.

Authors:  N J Willumsen; R C Boucher
Journal:  J Physiol       Date:  1992-09       Impact factor: 5.182

10.  Steroid hormones: modulators of Na+ absorption and Cl- secretion in cultured tracheal epithelia.

Authors:  P L Zeitlin; M Wagner; D Markakis; G M Loughlin; W B Guggino
Journal:  Proc Natl Acad Sci U S A       Date:  1989-04       Impact factor: 11.205
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