Othman Bin Alamer1,2, Paolo Palmisciano3, Scott E Rowe4, Aditya Dutta Gupta5, Maryam Haider6, Mohammed Alduhaymi7, Aaron A Cohen-Gadol8, Kenny Yu9, Tarek Y El-Ahmadieh9, Ali S Haider5,10. 1. College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi Arabia; Oabinalamer@gmail.com. 2. King Abdullah International Medical Research Center, Riyadh, Kingdom of Saudi Arabia. 3. Department of Neurosurgery, Trauma Center, Gamma Knife Center, Cannizzaro Hospital, Catania, Italy. 4. Nova Southeastern University College of Osteopathic Medicine, Fort Lauderdale, FL, U.S.A. 5. Texas A&M University College of Medicine, Houston, TX, U.S.A. 6. Department of Radiology, Baylor College of Medicine, Houston, TX, U.S.A. 7. College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi Arabia. 8. Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, U.S.A. 9. Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY, U.S.A. 10. Department of Neurosurgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX, U.S.A.
Abstract
BACKGROUND/AIM: To review the current literature on pineal region gliomas, summarizing the clinical characteristics and treatment outcomes. MATERIALS AND METHODS: PubMed, Scopus, and Cochrane databases were used to identify relevant articles. Comprehensive clinical characteristic review and survival analysis were conducted. RESULTS: Twelve studies describing 81 patients were included. The median age was 39 years (male=54.3%). Fifty patients (61.7%) had obstructive hydrocephalus requiring cerebrospinal fluid diversion with either ventriculoperitoneal shunt (VPS) (40.0%) or endoscopic third ventriculostomy (ETV) (24.0%). Patients who underwent VPS had significant survival benefits compared to ETV (p<0.05). All patients in our review underwent surgery, and gross-total resection (≥98%) was achieved in 34.6%. The supracerebellar infratentorial approach was the most employed surgical approach (62.3%). Chemotherapy was administered in 32.1% of cases, and radiotherapy in 40.7%. The median overall survival (OS) was 12 months, and the overall one-year survival rate was 60%. CONCLUSION: This study could not establish a correlation between the extent of tumor resection and positive treatment outcomes. However, among cases with hydrocephalus, patients who underwent VPS placement had better survival as compared to ETV.
BACKGROUND/AIM: To review the current literature on pineal region gliomas, summarizing the clinical characteristics and treatment outcomes. MATERIALS AND METHODS: PubMed, Scopus, and Cochrane databases were used to identify relevant articles. Comprehensive clinical characteristic review and survival analysis were conducted. RESULTS: Twelve studies describing 81 patients were included. The median age was 39 years (male=54.3%). Fifty patients (61.7%) had obstructive hydrocephalus requiring cerebrospinal fluid diversion with either ventriculoperitoneal shunt (VPS) (40.0%) or endoscopic third ventriculostomy (ETV) (24.0%). Patients who underwent VPS had significant survival benefits compared to ETV (p<0.05). All patients in our review underwent surgery, and gross-total resection (≥98%) was achieved in 34.6%. The supracerebellar infratentorial approach was the most employed surgical approach (62.3%). Chemotherapy was administered in 32.1% of cases, and radiotherapy in 40.7%. The median overall survival (OS) was 12 months, and the overall one-year survival rate was 60%. CONCLUSION: This study could not establish a correlation between the extent of tumor resection and positive treatment outcomes. However, among cases with hydrocephalus, patients who underwent VPS placement had better survival as compared to ETV.
Authors: Othman Bin-Alamer; Ali S Haider; Adhiraj Chaudhary; Kishore Balasubramanian; Tessa Breeding; Paolo Palmisciano; Maryam Haider; Aaron A Cohen-Gadol; Tarek Y El Ahmadieh; Kenny Yu Journal: Cancer Diagn Progn Date: 2022-09-03
Authors: Paolo Palmisciano; Gianluca Ferini; Gina Watanabe; Christian Ogasawara; Emal Lesha; Othman Bin-Alamer; Giuseppe E Umana; Kenny Yu; Aaron A Cohen-Gadol; Tarek Y El Ahmadieh; Ali S Haider Journal: Cancers (Basel) Date: 2022-05-19 Impact factor: 6.575