| Literature DB >> 35218508 |
Najeeb Ahmed1,2, Alyaa Sadeq3, Fahad Marafi3, Gopinath Gnanasegaran4, Sharjeel Usmani5,6.
Abstract
18F-Sodium fluoride (18F-NaF) is a PET tracer that is mostly used in the evaluation of bone metastasis in oncology cases. Recently, 18F-NaF PET/CT is gaining wide popularity owing to its higher sensitivity over the other conventional bone tracer with higher and rapid single-pass extraction, negligible plasma protein binding, rapid blood, and renal clearance. In the era of constant evolution of cancer therapy regimens, considerable bone health impact is seen in the form of avascular necrosis, insufficiency fractures, among others. A significant number of these therapy-induced changes show high bone turnover and thereby 18F-NaF accumulation, mimicking metastatic lesions. This article summarizes and illustrates the pattern and morphological features of 18F-NaF PET/CT findings in these changes in the context of clinical and therapeutic history.Entities:
Keywords: 18F-NaF PET–CT; Bone metastases; Cancer; Therapy-induced changes
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Year: 2022 PMID： 35218508 DOI： 10.1007/s12149-022-01730-y
Source DB: PubMed Journal: Ann Nucl Med ISSN： 0914-7187 Impact factor: 2.668