Kyongtae T Bae1, Cheng Tao2, Robert Feldman3, Alan S L Yu4,5, Vicente E Torres6, Ronald D Perrone7, Arlene B Chapman8, Godela Brosnahan9, Theodore I Steinman10, William E Braun11, Michal Mrug12,13, William M Bennett14, Peter C Harris6, Avantika Srivastava15, Douglas P Landsittel15, Kaleab Z Abebe3. 1. Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania baek@upmc.edu. 2. Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. 3. Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. 4. Division of Nephrology and Hypertension, Department of Internal Medicine, Kansas University Medical Center, Kansas City, Kansas. 5. Jared Grantham Kidney Institute, Kansas University Medical Center, Kansas City, Kansas. 6. Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, Minnesota. 7. Division of Nephrology, Tufts Medical Center, Boston, Massachusetts. 8. Section of Nephrology, University of Chicago School of Medicine, Chicago, Illinois. 9. Division of Diseases and Hypertension, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado. 10. Renal Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts. 11. Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, Ohio. 12. Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama. 13. Department of Veterans Affairs Medical Center, Birmingham, Alabama. 14. Legacy Good Samaritan Hospital, Portland, Oregon. 15. Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Abstract
BACKGROUND AND OBJECTIVES: The progression of polycystic liver disease is not well understood. The purpose of the study is to evaluate the associations of polycystic liver progression with other disease progression variables and classify liver progression on the basis of patient's age, height-adjusted liver cystic volume, and height-adjusted liver volume. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Prospective longitudinal magnetic resonance images from 670 patients with early autosomal dominant polycystic kidney disease for up to 14 years of follow-up were evaluated to measure height-adjusted liver cystic volume and height-adjusted liver volume. Among them, 245 patients with liver cyst volume >50 ml at baseline were included in the longitudinal analysis. Linear mixed models on log-transformed height-adjusted liver cystic volume and height-adjusted liver volume were fitted to approximate mean annual rate of change for each outcome. The association of sex, body mass index, genotype, baseline height-adjusted total kidney volume, and Mayo imaging class was assessed. We calculated height-adjusted liver cystic volume ranges for each specific age and divided them into five classes on the basis of annual percentage increase in height-adjusted liver cystic volume. RESULTS: The mean annual growth rate of height-adjusted liver cystic volume was 12% (95% confidence interval, 11.1% to 13.1%; P<0.001), whereas that for height-adjusted liver volume was 2% (95% confidence interval, 1.9% to 2.6%; P<0.001). Women had higher baseline height-adjusted liver cystic volume than men, but men had higher height-adjusted liver cystic volume growth rate than women by 2% (95% confidence interval, 0.4% to 4.5%; P=0.02). Whereas the height-adjusted liver cystic volume growth rate decreased in women after menopause, no decrease was observed in men at any age. Body mass index, genotype, and baseline height-adjusted total kidney volume were not associated with the growth rate of height-adjusted liver cystic volume or height-adjusted liver volume. According to the height-adjusted liver cystic volume growth rate, patients were classified into five classes (number of women, men in each class): A (24, six); B (44, 13); C (43, 48); D (28, 17); and E (13, nine). CONCLUSIONS: Compared with height-adjusted liver volume, the use of height-adjusted liver cystic volume showed greater separations in volumetric progression of polycystic liver disease. Similar to the Mayo imaging classification for the kidney, the progression of polycystic liver disease may be categorized on the basis of patient's age and height-adjusted liver cystic volume.
BACKGROUND AND OBJECTIVES: The progression of polycystic liver disease is not well understood. The purpose of the study is to evaluate the associations of polycystic liver progression with other disease progression variables and classify liver progression on the basis of patient's age, height-adjusted liver cystic volume, and height-adjusted liver volume. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Prospective longitudinal magnetic resonance images from 670 patients with early autosomal dominant polycystic kidney disease for up to 14 years of follow-up were evaluated to measure height-adjusted liver cystic volume and height-adjusted liver volume. Among them, 245 patients with liver cyst volume >50 ml at baseline were included in the longitudinal analysis. Linear mixed models on log-transformed height-adjusted liver cystic volume and height-adjusted liver volume were fitted to approximate mean annual rate of change for each outcome. The association of sex, body mass index, genotype, baseline height-adjusted total kidney volume, and Mayo imaging class was assessed. We calculated height-adjusted liver cystic volume ranges for each specific age and divided them into five classes on the basis of annual percentage increase in height-adjusted liver cystic volume. RESULTS: The mean annual growth rate of height-adjusted liver cystic volume was 12% (95% confidence interval, 11.1% to 13.1%; P<0.001), whereas that for height-adjusted liver volume was 2% (95% confidence interval, 1.9% to 2.6%; P<0.001). Women had higher baseline height-adjusted liver cystic volume than men, but men had higher height-adjusted liver cystic volume growth rate than women by 2% (95% confidence interval, 0.4% to 4.5%; P=0.02). Whereas the height-adjusted liver cystic volume growth rate decreased in women after menopause, no decrease was observed in men at any age. Body mass index, genotype, and baseline height-adjusted total kidney volume were not associated with the growth rate of height-adjusted liver cystic volume or height-adjusted liver volume. According to the height-adjusted liver cystic volume growth rate, patients were classified into five classes (number of women, men in each class): A (24, six); B (44, 13); C (43, 48); D (28, 17); and E (13, nine). CONCLUSIONS: Compared with height-adjusted liver volume, the use of height-adjusted liver cystic volume showed greater separations in volumetric progression of polycystic liver disease. Similar to the Mayo imaging classification for the kidney, the progression of polycystic liver disease may be categorized on the basis of patient's age and height-adjusted liver cystic volume.
Authors: Joost P H Drenth; Melissa Chrispijn; David M Nagorney; Patrick S Kamath; Vicente E Torres Journal: Hepatology Date: 2010-12 Impact factor: 17.425
Authors: Marie C Hogan; Kaleab Abebe; Vicente E Torres; Arlene B Chapman; Kyongtae T Bae; Cheng Tao; Hongliang Sun; Ronald D Perrone; Theodore I Steinman; William Braun; Franz T Winklhofer; Dana C Miskulin; Frederic Rahbari-Oskoui; Godela Brosnahan; Amirali Masoumi; Irina O Karpov; Susan Spillane; Michael Flessner; Charity G Moore; Robert W Schrier Journal: Clin Gastroenterol Hepatol Date: 2014-08-09 Impact factor: 11.382
Authors: Kyongtae T Bae; Tiange Shi; Cheng Tao; Alan S L Yu; Vicente E Torres; Ronald D Perrone; Arlene B Chapman; Godela Brosnahan; Theodore I Steinman; William E Braun; Avantika Srivastava; Maria V Irazabal; Kaleab Z Abebe; Peter C Harris; Douglas P Landsittel Journal: J Am Soc Nephrol Date: 2020-06-02 Impact factor: 10.121
Authors: Tom J G Gevers; Joanna Inthout; Anna Caroli; Piero Ruggenenti; Marie C Hogan; Vicente E Torres; Frederik Nevens; Joost P H Drenth Journal: Gastroenterology Date: 2013-05-07 Impact factor: 22.682