| Literature DB >> 35216939 |
Othman Salim Akhtar1, Li-Wen Huang2, Mazie Tsang3, Pallawi Torka4, Kah Poh Loh5, Vicki A Morrison6, Raul Cordoba7.
Abstract
Non-Hodgkin lymphoma (NHL) is a disease of older adults, with a median age at diagnosis of 67 years. Treatment in older adults with NHL is challenging. The aging process is associated with a decline in functional reserve that varies among individuals, and results in an increasing risk of treatment-related toxicity and mortality. Chronological age and performance status fail to capture the multidimensional and heterogeneous nature of the aging process. A geriatric assessment (GA) screens multiple geriatric domains and provides a more accurate assessment of functional reserve. Several abbreviated GA tools have been developed for use in oncology clinics and help identify patients at high risk for chemotherapy-related toxicity and mortality. In this review, we explore GA tools validated for use in patients with NHL. We discuss the evidence behind GA-guided treatment in NHL and present a suggested approach to assessing frailty in this patient population.Entities:
Keywords: Frailty; Geriatric assessment; Lymphoma; Non-Hodgkin lymphoma; Older adults
Mesh：
Year: 2022 PMID： 35216939 PMCID： PMC9232919 DOI： 10.1016/j.jgo.2022.02.005
Source DB: PubMed Journal: J Geriatr Oncol ISSN： 1879-4068 Impact factor: 3.929