Miriam T Ashford1, Rema Raman2, Garrett Miller2, Michael C Donohue2, Ozioma C Okonkwo3, Monica Rivera Mindt4, Rachel L Nosheny5, Godfrey A Coker2, Ronald C Petersen6, Paul S Aisen2, Michael W Weiner7. 1. Department of Veterans Affairs Medical Center, Northern California Institute for Research and Education (NCIRE), San Francisco, California, USA. 2. Alzheimer's Therapeutic Research Institute, University of Southern California, San Francisco, California, USA. 3. Wisconsin Alzheimer's Disease Research Center and The Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA. 4. Psychology & Latin American Latino Studies Institute, Fordham University, Joint Appointment in Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. 5. Department of Psychiatry, University of California San Francisco, San Francisco, USA. 6. Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA. 7. Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
Abstract
INTRODUCTION: An analysis of the ethnocultural and socioeconomic composition of Alzheimer's Disease Neuroimaging Initiative (ADNI) participants is needed to assess the generalizability of ADNI data to diverse populations. METHODS: ADNI data collected between October 2004 and November 2020 were used to determine ethnocultural and educational composition of the sample and differences in the following metrics: screening, screen fails, enrollment, biomarkers. RESULTS: Of 3739 screened individuals, 11% identified as being from ethnoculturally underrepresented populations (e.g., Black, Latinx) and 16% had <12 years of education. Of 2286 enrolled participants, 11% identified as ethnoculturally underrepresented individuals and 15% had <12 years of education. This participation is considerably lower than US Census data for adults 60+ (ethnoculturally underrepresented populations: 25%; <12 years of education: 4%). Individuals with <12 years of education failed screening at a higher rate. DISCUSSION: Our findings suggest that ADNI results may not be entirely generalizable to ethnoculturally diverse and low education populations.
INTRODUCTION: An analysis of the ethnocultural and socioeconomic composition of Alzheimer's Disease Neuroimaging Initiative (ADNI) participants is needed to assess the generalizability of ADNI data to diverse populations. METHODS: ADNI data collected between October 2004 and November 2020 were used to determine ethnocultural and educational composition of the sample and differences in the following metrics: screening, screen fails, enrollment, biomarkers. RESULTS: Of 3739 screened individuals, 11% identified as being from ethnoculturally underrepresented populations (e.g., Black, Latinx) and 16% had <12 years of education. Of 2286 enrolled participants, 11% identified as ethnoculturally underrepresented individuals and 15% had <12 years of education. This participation is considerably lower than US Census data for adults 60+ (ethnoculturally underrepresented populations: 25%; <12 years of education: 4%). Individuals with <12 years of education failed screening at a higher rate. DISCUSSION: Our findings suggest that ADNI results may not be entirely generalizable to ethnoculturally diverse and low education populations.
Authors: Joshua D Grill; Jimmy Kwon; Merilee A Teylan; Aimee Pierce; Eric D Vidoni; Jeffrey M Burns; Allison Lindauer; Joseph Quinn; Jeff Kaye; Daniel L Gillen; Bin Nan Journal: Alzheimer Dis Assoc Disord Date: 2019 Oct-Dec Impact factor: 2.703
Authors: Jasenka Demirovic; Ronald Prineas; David Loewenstein; Judy Bean; Ranjan Duara; Steven Sevush; Jose Szapocznik Journal: Ann Epidemiol Date: 2003-07 Impact factor: 3.797
Authors: Iain A Lang; David J Llewellyn; Kenneth M Langa; Robert B Wallace; Felicia A Huppert; David Melzer Journal: J Am Geriatr Soc Date: 2007-12-24 Impact factor: 5.562
Authors: Paul Brewster; Lisa Barnes; Mary Haan; Julene K Johnson; Jennifer J Manly; Anna María Nápoles; Rachel A Whitmer; Luis Carvajal-Carmona; Dawnte Early; Sarah Farias; Elizabeth Rose Mayeda; Rebecca Melrose; Oanh L Meyer; Adina Zeki Al Hazzouri; Ladson Hinton; Dan Mungas Journal: Alzheimers Dement Date: 2018-09-19 Impact factor: 21.566
Authors: Madeleine M Blazel; Karen K Lazar; Carol A Van Hulle; Yue Ma; Aleshia Cole; Alice Spalitta; Nancy Davenport-Sis; Barbara B Bendlin; Michelle Wahoske; Chuck Illingworth; Carey E Gleason; Dorothy F Edwards; Hanna Blazel; Sanjay Asthana; Sterling C Johnson; Cynthia M Carlsson Journal: J Alzheimers Dis Date: 2020 Impact factor: 4.472