| Literature DB >> 35213372 |
Heidi I L Jacobs1,2,3,4, Adrienne O'Donnell5,6, Claudia L Satizabal6,7,8, Cristina Lois1,2,4, Daniel Kojis5,6, Bernard J Hanseeuw1,4,9, Emma Thibault1,4, Justin S Sanchez1,4, Rachel F Buckley1,2,10, Qiong Yang5, Charles DeCarli11, Ron Killiany7, Muralidharan Sargurupremraj8, Reisa A Sperling1,2,12, Keith A Johnson1,2,4,12, Alexa S Beiser5,6,7, Sudha Seshadri6,7,8.
Abstract
The brainstem is among the first regions to accumulate Alzheimer's disease (AD)-related hyperphosphorylated tau pathology during aging. We aimed to examine associations between brainstem volume and neocortical amyloid-β or tau pathology in 271 middle-aged clinically normal individuals of the Framingham Heart Study who underwent MRI and PET imaging. Lower volume of the medulla, pons, or midbrain was associated with greater neocortical amyloid burden. No associations were detected between brainstem volumes and tau deposition. Our results support the hypothesis that lower brainstem volumes are associated with initial AD-related processes and may signal preclinical AD pathology.Entities:
Keywords: Aging; amyloid; brainstem; tau
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Year: 2022 PMID： 35213372 PMCID： PMC9038711 DOI： 10.3233/JAD-215372
Source DB: PubMed Journal: J Alzheimers Dis ISSN： 1387-2877 Impact factor: 4.160