Michael L Williams1,2,3, Madeleine de Boer4, Bridget Hwang2, Bruce Wilson2, John Brookes2,5, Nicholas McNamara6, David H Tian7, Timothy Shiraev4, Ourania Preventza8,9. 1. Department of Cardiothoracic Surgery, John Hunter Hospital, Newcastle, Australia. 2. The Collaborative Research (CORE) Group, Macquarie University, Sydney, Australia. 3. School of Medicine and Public Health, University of Newcastle, Newcastle, Australia. 4. Department of Vascular Surgery, Royal Prince Alfred Hospital, Sydney, Australia. 5. Department of Cardiothoracic Surgery, University Hospital Geelong, Geelong, Australia. 6. Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia. 7. Department of Anaesthesia and Perioperative Medicine, Westmead Hospital, Sydney, Australia. 8. Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA. 9. Department of Cardiovascular Surgery, Texas Heart Institute, Houston, Texas, USA.
Abstract
BACKGROUND: At present, the optimal management strategy for chronic type B aortic dissection (CTBAD) remains unknown, as equipoise remains regarding medical management versus endovascular treatment versus open surgery. However, the results over recent years of thoracic endovascular aortic repair (TEVAR) in CTBAD appear promising. The aim of this systematic review was to provide a comprehensive analysis of the available data reporting outcomes and survival rates for TEVAR in CTBAD. METHODS: Electronic searches of six databases were performed from inception to April 2021. All studies reporting outcomes, specifically 30-day mortality rates, for endovascular repair of CTBAD were identified. Relevant data were extracted, and a random-effects meta-analysis of proportions or means was performed to aggregate the data. Survival data were pooled using data derived from original Kaplan-Meier curves, which allows reconstruction of individual patient data. RESULTS: Forty-eight studies with 2,641 patients were identified. Early (<30 days) all-cause and aortic-related mortality rates were low at 1.6% and 0.5%, respectively. Incidence of retrograde type A dissection in the post-operative period was only 1.4%. There were also low rates of cerebrovascular accidents and spinal cord injury (1.1% and 0.9%, respectively). Late follow-up all-cause mortality was 8.0%, however, late aortic-related mortality was only 2.4%. Reintervention rates were 10.1% for endovascular and 6.7% for surgical reintervention. Pooled rates of overall survival at 1-, 3-, 5- and 10-year were 91.5%, 84.7%, 77.7% and 56.3%, respectively. CONCLUSIONS: The significant heterogeneity in the available evidence and absence of consensus reporting standards are important considerations and concern when interpreting the data. Evaluation of the evidence suggests that TEVAR for CTBAD is a safe procedure with low rates of complications. However, the optimal treatment strategy for CTBAD remains debatable and requires further research. Evidence from high-quality registries and clinical trials are required to address these challenges. 2022 Annals of Cardiothoracic Surgery. All rights reserved.
BACKGROUND: At present, the optimal management strategy for chronic type B aortic dissection (CTBAD) remains unknown, as equipoise remains regarding medical management versus endovascular treatment versus open surgery. However, the results over recent years of thoracic endovascular aortic repair (TEVAR) in CTBAD appear promising. The aim of this systematic review was to provide a comprehensive analysis of the available data reporting outcomes and survival rates for TEVAR in CTBAD. METHODS: Electronic searches of six databases were performed from inception to April 2021. All studies reporting outcomes, specifically 30-day mortality rates, for endovascular repair of CTBAD were identified. Relevant data were extracted, and a random-effects meta-analysis of proportions or means was performed to aggregate the data. Survival data were pooled using data derived from original Kaplan-Meier curves, which allows reconstruction of individual patient data. RESULTS: Forty-eight studies with 2,641 patients were identified. Early (<30 days) all-cause and aortic-related mortality rates were low at 1.6% and 0.5%, respectively. Incidence of retrograde type A dissection in the post-operative period was only 1.4%. There were also low rates of cerebrovascular accidents and spinal cord injury (1.1% and 0.9%, respectively). Late follow-up all-cause mortality was 8.0%, however, late aortic-related mortality was only 2.4%. Reintervention rates were 10.1% for endovascular and 6.7% for surgical reintervention. Pooled rates of overall survival at 1-, 3-, 5- and 10-year were 91.5%, 84.7%, 77.7% and 56.3%, respectively. CONCLUSIONS: The significant heterogeneity in the available evidence and absence of consensus reporting standards are important considerations and concern when interpreting the data. Evaluation of the evidence suggests that TEVAR for CTBAD is a safe procedure with low rates of complications. However, the optimal treatment strategy for CTBAD remains debatable and requires further research. Evidence from high-quality registries and clinical trials are required to address these challenges. 2022 Annals of Cardiothoracic Surgery. All rights reserved.
Entities:
Keywords:
Chronic type B aortic dissection (CTBAD); descending thoracic aorta; thoracic endovascular aortic repair (TEVAR)
Authors: V Riambau; D Böckler; J Brunkwall; P Cao; R Chiesa; G Coppi; M Czerny; G Fraedrich; S Haulon; M J Jacobs; M L Lachat; F L Moll; C Setacci; P R Taylor; M Thompson; S Trimarchi; H J Verhagen; E L Verhoeven; P Kolh; G J de Borst; N Chakfé; E S Debus; R J Hinchliffe; S Kakkos; I Koncar; J S Lindholt; M Vega de Ceniga; F Vermassen; F Verzini; P Kolh; J H Black; R Busund; M Björck; M Dake; F Dick; H Eggebrecht; A Evangelista; M Grabenwöger; R Milner; A R Naylor; J-B Ricco; H Rousseau; J Schmidli Journal: Eur J Vasc Endovasc Surg Date: 2017-01 Impact factor: 7.069
Authors: Jun Woo Cho; Suk Jung Choo; Chul Ho Lee; Ho Jin Kim; Joon Bum Kim; Sung Ho Jung; Cheol Hyun Chung; Sung Ho Shinn; Jae Won Lee Journal: J Vasc Surg Date: 2020-07-25 Impact factor: 4.268
Authors: Derek P Nathan; Sherene Shalhub; Gale L Tang; Matthew P Sweet; Edward D Verrier; Nam T Tran; Gabriel S Aldea; Benjamin W Starnes Journal: J Vasc Surg Date: 2015-03-12 Impact factor: 4.268
Authors: K Mani; R E Clough; O T A Lyons; R E Bell; T W Carrell; H A Zayed; M Waltham; P R Taylor Journal: Eur J Vasc Endovasc Surg Date: 2012-02-09 Impact factor: 7.069