Comparing Analgesic Efficacy of Regional Block Techniques After Laparoscopic Liver Resection [Letter].

Dear editor

The recent article of Kang et al1 comparing analgesic efficacy of erector spinae plane block (ESPB) and posterior quadratus lumborum block (PQLB) after laparoscopic liver resection in a randomized controlled trial was of great interest. They concluded that two regional blocks provided similar postoperative analgesia. However, we would like to remind the readers of several issues in the design and results of this study and wish to invite the authors to comment.

First, primary outcome of this study was cumulative opioid consumption in the first postoperative 24 h. The sample size calculation was based on the findings of a previous study2 and their retrospective data, by which the calculated mean ± standard deviation of IV morphine equivalents (IME) for cumulative opioid consumption in the first postoperative 24 h was 45.5±21.8 mg. Furthermore, the authors considered that a 30% reduction of mean IME in the PQLB group compared to the ESPB group was a clinically important difference. According to available literature, however, the recommended minimal clinically important difference of postoperative cumulative opioid consumption is an absolute reduction of 10 mg morphine in the IME for 24 h.3 As the expected minimal clinically important difference of primary outcome between groups in this study is significantly larger than the recommended value in the literature, we cannot exclude the possibility of insufficient power to show the significant difference of primary outcome between groups.

Second, other than PQLB and ESPB, a standardized supplemental analgesic regimen was also used for postoperative pain control. It is generally believed that satisfactory postoperative pain control should achieve a numerical rating scale (NRS) score of 3 or less.4 According to Figure 2 of Kang et al’s article,1 we noted that the means of postoperative resting pain NRS scores in the PACU stay, and at 24 h and 48 h after surgery in the two groups were more than 4, with large standard deviations. Even the means of highest postoperative resting pain NRS scores during the PACU stay in the two groups were more than 6. These results indicate that a significant number of patients experienced moderate to severe postoperative resting pain within 48 h after surgery. Furthermore, it is conceivable that pain intensity on active status will be more severe, though this study did not evaluate this variable. Actually, in this study, the proportion of patients who were “satisfied” and “very satisfied” with pain relief at 24 h after surgery was only 71–79%. This is not ideal postoperative pain control for the successful use of enhanced recovery after surgery protocols, in which multimodal analgesic regimen is recommended and analgesics should be universally titrated to achieve minimal postoperative pain, ie, a pain NRS score of 3 or less.4

Finally, this study observed the cumulative opioid consumption, resting pain VAS scores and the occurrence of nausea or vomiting at 24 h, 48 h and 72 h after surgery, but it only assessed the Quality of Recovery-15 (QoR-15) scores at 24 h after surgery. The available evidence indicates that measurement of the QoR-15 score on the day of surgery may not be reliable.5 Most important, mean QoR-15 scores at 24 h after surgery in the two groups were only about 73% of preoperative baselines, indicating a poor quality of early postoperative recovery. As the QoR-15 score was only assessed at a single time point, moreover, an important issue that this study cannot answer is whether the PQLB and ESPB groups were comparable with respect to the quality of recovery after first postoperative 24 h. Given the facts that the QoR-15 questionnaire has good acceptability and feasibility in clinical practice and most patients can complete the questionnaire in less than 3 min,6 we suggest that the QoR-15 score should be repeatedly assessed at the time points after first postoperative 24 h, if the quality outcomes of enhanced recovery after surgery protocols are the measured variables of study design.