Literature DB >> 35199725

Metronidazole Induced Cerebellar Toxicity: A Case Report.

Shova Sapkota1, Aliska Niroula1, Rina Prajapati2, Subhani Sharma2, Krishna Dhungana2.   

Abstract

Metronidazole is a widely used antibiotic against bacterial and protozoan infections. Even though the therapeutic use of the drug is high, it is associated with some severe side effects like neurotoxicity such as optic neuropathy, peripheral neuropathy, encephalopathy and cerebellar toxicity. We present a case of a 55-years male presented with dysarthria, who had positive cerebellar sign and magnetic resonance imaging findings suggestive of metronidazole induced cerebellar toxicity following metronidazole therapy for two months in a case of liver abscess. And, the symptoms resolved after cessation of metronidazole.

Entities:  

Keywords:  case report; cerebellar toxicity; metronidazole; side effect.

Mesh:

Substances:

Year:  2021        PMID: 35199725      PMCID: PMC9107893          DOI: 10.31729/jnma.6644

Source DB:  PubMed          Journal:  JNMA J Nepal Med Assoc        ISSN: 0028-2715            Impact factor:   0.556


  8 in total

1.  Reversible metronidazole-induced lesions of the cerebellar dentate nuclei.

Authors:  Bryan K Woodruff; Eelco F M Wijdicks; William F Marshall
Journal:  N Engl J Med       Date:  2002-01-03       Impact factor: 91.245

2.  MR imaging of metronidazole-induced encephalopathy: lesion distribution and diffusion-weighted imaging findings.

Authors:  E Kim; D G Na; E Y Kim; J H Kim; K R Son; K H Chang
Journal:  AJNR Am J Neuroradiol       Date:  2007-09-20       Impact factor: 3.825

3.  Reversible cerebellar neurotoxicity induced by metronidazole.

Authors:  Ariel Lefkowitz; Steven Shadowitz
Journal:  CMAJ       Date:  2018-08-13       Impact factor: 8.262

Review 4.  Therapeutic uses of metronidazole and its side effects: an update.

Authors:  A Hernández Ceruelos; L C Romero-Quezada; J C Ruvalcaba Ledezma; L López Contreras
Journal:  Eur Rev Med Pharmacol Sci       Date:  2019-01       Impact factor: 3.507

Review 5.  Metronidazole-induced central nervous system toxicity: a systematic review.

Authors:  Akira Kuriyama; Jeffrey L Jackson; Asako Doi; Toru Kamiya
Journal:  Clin Neuropharmacol       Date:  2011 Nov-Dec       Impact factor: 1.592

Review 6.  Clinical and Neuroradiological Spectrum of Metronidazole Induced Encephalopathy: Our Experience and the Review of Literature.

Authors:  Ujjawal Roy; Ajay Panwar; Alak Pandit; Susanta Kumar Das; Bhushan Joshi
Journal:  J Clin Diagn Res       Date:  2016-06-01

7.  Metronidazole and hydroxymetronidazole central nervous system distribution: 1. microdialysis assessment of brain extracellular fluid concentrations in patients with acute brain injury.

Authors:  Denis Frasca; Claire Dahyot-Fizelier; Christophe Adier; Olivier Mimoz; Bertrand Debaene; William Couet; Sandrine Marchand
Journal:  Antimicrob Agents Chemother       Date:  2013-11-25       Impact factor: 5.191

8.  Metronidazole-Induced Cerebellar Toxicity.

Authors:  Amit Agarwal; Sangam Kanekar; Shyam Sabat; Krishnamurthy Thamburaj
Journal:  Neurol Int       Date:  2016-04-01
  8 in total

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