Erika Meléndez-Oliva1, Isabel Sánchez-Vera Gómez-Trelles2, Eva Segura-Orti3, Borja Pérez-Domínguez3, Rafael García-Maset4, Alicia García-Testal4, Jose Luis Lavandera-Díaz5. 1. Department of Biomedical Sciences, Universidad CEU Cardenal Herrera, CEU Universities, Elche, Spain. erikamelendezoliva@gmail.com. 2. Department of Basic Medical Sciences. Medical School, Universidad CEU San Pablo, CEU Universities, Madrid, Spain. 3. Department of Physiotherapy, Universidad CEU Cardenal Herrera, CEU Universities, Valencia, Spain. 4. Nephrology Department, Hospital de Manises, Valencia, Spain. 5. Department of Basic Medical Sciences. Medical School, Universidad CEU San Pablo, CEU Universities, Madrid, Spain. joseluis.lavandera@ceu.es.
Abstract
BACKGROUND: Chronic kidney disease patients on hemodialysis treatment are characterized by increased levels of inflammatory markers and oxidative stress, in addition to a significant deterioration in physical function. The benefits of physical exercise on the functional capacity of this patients are well known; however, it can also improve the endogenous antioxidant defense system and the inflammatory state, but still very few studies have been carried out. This is the first study to analyze the effect of a 4-month exercise program with combined aerobic and strength training in patients undergoing hemodialysis, under two modalities. METHODS: Seventy-one patients undergoing hemodialysis were enrolled and randomized in two groups, one of them performing an intra-dialysis exercise program (n = 36), and the other carrying out a home-based exercise program (n = 35). Serum levels of oxidative stress and inflammation biomarkers were determined before and after the intervention. RESULTS: IL-6 plasma levels showed a significant decrease in the intra-dialysis group after exercise (42.61 ± 9.21 to 26.40 ± 7.84, p = 0.03), while CRP levels decreased significantly in the home-based group (16.12 ± 24.18 to 8.50 ± 11.28, p = 0.03). MCP-1, TNF-α, ICAM-1 and the oxidative stress markers MDA, GSH and GSSG, did not undergo significant changes after the intervention. CONCLUSION: Four months of combined strength and aerobic endurance exercise improve the inflammatory status of hemodialysis patients by significantly reducing IL-6 levels in those subjects who perform intra-dialysis exercise and CRP levels in those who do it at home.
BACKGROUND: Chronic kidney disease patients on hemodialysis treatment are characterized by increased levels of inflammatory markers and oxidative stress, in addition to a significant deterioration in physical function. The benefits of physical exercise on the functional capacity of this patients are well known; however, it can also improve the endogenous antioxidant defense system and the inflammatory state, but still very few studies have been carried out. This is the first study to analyze the effect of a 4-month exercise program with combined aerobic and strength training in patients undergoing hemodialysis, under two modalities. METHODS: Seventy-one patients undergoing hemodialysis were enrolled and randomized in two groups, one of them performing an intra-dialysis exercise program (n = 36), and the other carrying out a home-based exercise program (n = 35). Serum levels of oxidative stress and inflammation biomarkers were determined before and after the intervention. RESULTS: IL-6 plasma levels showed a significant decrease in the intra-dialysis group after exercise (42.61 ± 9.21 to 26.40 ± 7.84, p = 0.03), while CRP levels decreased significantly in the home-based group (16.12 ± 24.18 to 8.50 ± 11.28, p = 0.03). MCP-1, TNF-α, ICAM-1 and the oxidative stress markers MDA, GSH and GSSG, did not undergo significant changes after the intervention. CONCLUSION: Four months of combined strength and aerobic endurance exercise improve the inflammatory status of hemodialysis patients by significantly reducing IL-6 levels in those subjects who perform intra-dialysis exercise and CRP levels in those who do it at home.
Authors: G H Heine; C Ulrich; E Seibert; S Seiler; J Marell; B Reichart; M Krause; A Schlitt; H Köhler; M Girndt Journal: Kidney Int Date: 2007-12-26 Impact factor: 10.612
Authors: Maurice Dungey; Katherine L Hull; Alice C Smith; James O Burton; Nicolette C Bishop Journal: Int J Endocrinol Date: 2013-05-13 Impact factor: 3.257
Authors: Erika Meléndez Oliva; Jorge H Villafañe; Jose Luis Alonso Pérez; Alexandra Alonso Sal; Guillermo Molinero Carlier; Andrés Quevedo García; Silvia Turroni; Oliver Martínez-Pozas; Norberto Valcárcel Izquierdo; Eleuterio A Sánchez Romero Journal: J Pers Med Date: 2022-07-21