Literature DB >> 35198331

Arrhythmia With Lithium Toxicity Requiring Urgent Dialysis: A Case Report.

Swarup Sharma Rijal1, Ibiyemi Oke1, Biraj Shrestha1.   

Abstract

Lithium has been widely used as a mood stabilizer. With its narrow therapeutic index, systemic side effects, primarily neurological are a concern. Cardiotoxic effects of lithium are rare, reported as non-specific T-wave flattening, prolonged QT interval, sinus node dysfunction, ventricular tachycardia, cardiomyopathy, and myocardial infarction. We report an interesting case of a young female patient with schizoaffective disorder on lithium who developed life-threatening cardiotoxicity secondary to lithium requiring urgent dialysis.
Copyright © 2022, Rijal et al.

Entities:  

Keywords:  atrial fibrillation; bradycardia; dialysis; lithium poisoning; schizoaffective disorder

Year:  2022        PMID: 35198331      PMCID: PMC8856736          DOI: 10.7759/cureus.21427

Source DB:  PubMed          Journal:  Cureus        ISSN: 2168-8184


  11 in total

1.  Sinoatrial nodal cell ryanodine receptor and Na(+)-Ca(2+) exchanger: molecular partners in pacemaker regulation.

Authors:  K Y Bogdanov; T M Vinogradova; E G Lakatta
Journal:  Circ Res       Date:  2001-06-22       Impact factor: 17.367

Review 2.  Clinical manifestations and management of acute lithium intoxication.

Authors:  M D Okusa; L J Crystal
Journal:  Am J Med       Date:  1994-10       Impact factor: 4.965

Review 3.  Prevalence, pathogenesis, and treatment of renal dysfunction associated with chronic lithium therapy.

Authors:  R Boton; M Gaviria; D C Batlle
Journal:  Am J Kidney Dis       Date:  1987-11       Impact factor: 8.860

4.  The association of the effect of lithium in the maintenance treatment of bipolar disorder with lithium plasma levels: a post hoc analysis of a double-blind study comparing switching to lithium or placebo in patients who responded to quetiapine (Trial 144).

Authors:  Willem A Nolen; Richard H Weisler
Journal:  Bipolar Disord       Date:  2012-12-10       Impact factor: 6.744

5.  Lithium overdose with electrocardiogram changes suggesting ischemia.

Authors:  Joshua Puhr; Jason Hack; Jacquelyn Early; William Price; William Meggs
Journal:  J Med Toxicol       Date:  2008-09

6.  Syncope caused by lithium treatment. Report on two cases and a prospective investigation of the prevalence of lithium-induced sinus node dysfunction.

Authors:  A Hagman; K Arnman; L Rydén
Journal:  Acta Med Scand       Date:  1979

7.  Rarely seen cardiotoxicity of lithium overdose: complete heart block.

Authors:  Mustafa Serinken; Ozgur Karcioglu; Ayhan Korkmaz
Journal:  Int J Cardiol       Date:  2008-02-20       Impact factor: 4.164

Review 8.  Lithium-induced electrocardiographic changes: A complete review.

Authors:  Nikhil Mehta; Robert Vannozzi
Journal:  Clin Cardiol       Date:  2017-12-16       Impact factor: 2.882

9.  Lithium-induced sinus node disease at therapeutic concentrations: linking lithium-induced blockade of sodium channels to impaired pacemaker activity.

Authors:  Gavin Y Oudit; Victoria Korley; Peter H Backx; Paul Dorian
Journal:  Can J Cardiol       Date:  2007-03-01       Impact factor: 5.223

Review 10.  Lithium side effects and toxicity: prevalence and management strategies.

Authors:  Michael Gitlin
Journal:  Int J Bipolar Disord       Date:  2016-12-17
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