Literature DB >> 35196391

Imeglimin to the Rescue: Enhanced CHOP/GADD34/eIF2α Signaling Axis Promotes β-Cell Survival.

Seokwon Jo, Emilyn U Alejandro.   

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Year:  2022        PMID： 35196391      PMCID： PMC8893936          DOI： 10.2337/dbi21-0035

Source DB:  PubMed          Journal:  Diabetes        ISSN： 0012-1797            Impact factor:   9.461


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  21 in total

1.  Impact of GADD34 on Apoptosis of Tonsillar Mononuclear Cells from IgA Nephropathy Patients by Regulating Eif2α Phosphorylation.

Authors:  Xiaofei Peng; Tao Yang; Liyu He; Xian Chen; Yafeng Jiang; Hao Zhang; Hong Liu; Youming Peng
Journal:  Cell Physiol Biochem       Date:  2018-11-09

2.  Imeglimin normalizes glucose tolerance and insulin sensitivity and improves mitochondrial function in liver of a high-fat, high-sucrose diet mice model.

Authors:  Guillaume Vial; Marie-Agnès Chauvin; Nadia Bendridi; Annie Durand; Emmanuelle Meugnier; Anne-Marie Madec; Nathalie Bernoud-Hubac; Jean-Paul Pais de Barros; Éric Fontaine; Cécile Acquaviva; Sophie Hallakou-Bozec; Sébastien Bolze; Hubert Vidal; Jennifer Rieusset
Journal:  Diabetes       Date:  2014-12-31       Impact factor: 9.461

3.  CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum.

Authors:  Stefan J Marciniak; Chi Y Yun; Seiichi Oyadomari; Isabel Novoa; Yuhong Zhang; Rivka Jungreis; Kazuhiro Nagata; Heather P Harding; David Ron
Journal:  Genes Dev       Date:  2004-12-15       Impact factor: 11.361

4.  Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes.

Authors:  Seiichi Oyadomari; Akio Koizumi; Kiyoshi Takeda; Tomomi Gotoh; Shizuo Akira; Eiichi Araki; Masataka Mori
Journal:  J Clin Invest       Date:  2002-02       Impact factor: 14.808

5.  Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2.

Authors:  Matthew H Brush; Douglas C Weiser; Shirish Shenolikar
Journal:  Mol Cell Biol       Date:  2003-02       Impact factor: 4.272

6.  Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes.

Authors:  Benbo Song; Donalyn Scheuner; David Ron; Subramaniam Pennathur; Randal J Kaufman
Journal:  J Clin Invest       Date:  2008-10       Impact factor: 14.808

Review 7.  Imeglimin Hydrochloride: First Approval.

Authors:  Yvette N Lamb
Journal:  Drugs       Date:  2021-09       Impact factor: 9.546

8.  Imeglimin prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration.

Authors:  D Detaille; G Vial; A-L Borel; C Cottet-Rouselle; S Hallakou-Bozec; S Bolze; P Fouqueray; E Fontaine
Journal:  Cell Death Discov       Date:  2016-01-18

Review 9.  Mechanism of action of Imeglimin: A novel therapeutic agent for type 2 diabetes.

Authors:  Sophie Hallakou-Bozec; Guillaume Vial; Micheline Kergoat; Pascale Fouqueray; Sébastien Bolze; Anne-Laure Borel; Eric Fontaine; David E Moller
Journal:  Diabetes Obes Metab       Date:  2020-12-29       Impact factor: 6.577

Review 10.  What Is the Sweetest UPR Flavor for the β-cell? That Is the Question.

Authors:  Alina Lenghel; Alina Maria Gheorghita; Andrei Mircea Vacaru; Ana-Maria Vacaru
Journal:  Front Endocrinol (Lausanne)       Date:  2021-01-19       Impact factor: 5.555
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