Merry Peckham1, Horace J Spencer1, Shorabuddin Syed1, William B Armstrong2, Donald Gregory Farwell3, Thomas J Gal4, David Goldenberg5, Marika D Russell6, Roberto N Solis7, Deanne King1, Brendan C Stack1,8. 1. University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. 2. Department of Otolaryngology - Head and Neck Surgery, University of California, Irvine, California, USA. 3. Department of Otorhinolaryngology - Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA. 4. Department of Otolaryngology - Head and Neck Surgery, University of Kentucky, Lexington, Kentucky, USA. 5. Department of Otolaryngology - Head and Neck Surgery, The Pennsylvania State University, Hershey, Pennsylvania, USA. 6. Department of Otolaryngology - Head and Neck Surgery, University of California, San Francisco, San Francisco, California, USA. 7. Department of Otolaryngology - Head and Neck Surgery, University of California, Davis, Davis, California, USA. 8. Department of Otolaryngology - Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, Illinois, USA.
Abstract
OBJECTIVE: To investigate a possible link between breast and thyroid cancer. METHODS: A multicenter retrospective review of patients in the electronic medical records of six Accrual to Clinical Trial (ACT) institutions with both breast cancer and thyroid carcinoma. Each center queried its data using a predefined data dictionary. Information on thyroid and breast cancer included dates of diagnosis, histology, and patient demographics. RESULTS: A random-effects model was used. There were 4.24 million women's records screened, 44 605 with breast cancer and 11 846 with thyroid cancer. The relative risks observed at each institution ranged from 0.49 to 13.47. The combined risk ratio (RR) estimate was 1.77 (95% confidence interval: 0.50-5.18). CONCLUSION: There was no association between the risk of developing thyroid cancer and being a breast cancer survivor compared to no history of breast cancer, but the range of relative risks among the participating institutions was wide. Our findings warrant further study of more institutions with larger sample size. Additionally, further analysis of the significance of regional RR differences may be enlightening.
OBJECTIVE: To investigate a possible link between breast and thyroid cancer. METHODS: A multicenter retrospective review of patients in the electronic medical records of six Accrual to Clinical Trial (ACT) institutions with both breast cancer and thyroid carcinoma. Each center queried its data using a predefined data dictionary. Information on thyroid and breast cancer included dates of diagnosis, histology, and patient demographics. RESULTS: A random-effects model was used. There were 4.24 million women's records screened, 44 605 with breast cancer and 11 846 with thyroid cancer. The relative risks observed at each institution ranged from 0.49 to 13.47. The combined risk ratio (RR) estimate was 1.77 (95% confidence interval: 0.50-5.18). CONCLUSION: There was no association between the risk of developing thyroid cancer and being a breast cancer survivor compared to no history of breast cancer, but the range of relative risks among the participating institutions was wide. Our findings warrant further study of more institutions with larger sample size. Additionally, further analysis of the significance of regional RR differences may be enlightening.
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