Literature DB >> 3519579

New role for photoreversible pyrimidine dimers in induction of prototrophic mutations in excision-deficient Escherichia coli by UV light.

M Ruiz-Rubio, R Woodgate, B A Bridges, G Herrera, M Blanco.   

Abstract

UV mutagenesis to His+ in certain recA441 lexA51 bacteria was not photoreversible, indicating that pyrimidine dimers are not target lesions. Photoreversibility was observed in recA+ lexA51 bacteria, showing that pyrimidine dimers are needed to activate the recA+ protein (unlike the recA441 protein) to perform a function in UV mutagenesis distinct from cleavage of the lexA repressor.

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Year:  1986        PMID： 3519579      PMCID： PMC215246          DOI： 10.1128/jb.166.3.1141-1143.1986

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  18 in total

1.  Genetic studies of the lac repressor. X. Analysis of missense mutations in the lacI gene.

Authors:  J H Miller; U Schmeissner
Journal:  J Mol Biol       Date:  1979-06-25       Impact factor: 5.469

2.  Mutants of Escherichia coli requiring methionine or vitamin B12.

Authors:  B D DAVIS; E S MINGIOLI
Journal:  J Bacteriol       Date:  1950-07       Impact factor: 3.490

3.  Mutation to prototrophy in Escherichia coli K-12: effect of broth on UV-induced mutation in strain AB1157 and four excision-deficient mutants.

Authors:  M H Green; M A Rothwell; B A Bridges
Journal:  Mutat Res       Date:  1972-11       Impact factor: 2.433

4.  Survival, mutation and capacity to repair single-strand DNA breaks after gamma irradiation in different Exr - strains of Escherichia coli.

Authors:  S G Sedgwick; B A Bridges
Journal:  Mol Gen Genet       Date:  1972

5.  Genetic studies of the lac repressor. IV. Mutagenic specificity in the lacI gene of Escherichia coli.

Authors:  C Coulondre; J H Miller
Journal:  J Mol Biol       Date:  1977-12-15       Impact factor: 5.469

6.  Differential induction and repair of ultraviolet damage leading to true revesions and external suppressor mutations of an ochre codon in Escherichia coli B-r WP2.

Authors:  B A Bridges; R E Dennis; R J Munson
Journal:  Genetics       Date:  1967-12       Impact factor: 4.562

7.  Mutagenic DNA repair in Escherichia coli. II. Factors affecting loss of photoreversibility of UV induced mutations.

Authors:  O P Doubleday; B A Bridges; M H Green
Journal:  Mol Gen Genet       Date:  1975-10-03

8.  The role of pyrimidine dimers as premutagenic lesions: a study of targeted vs. untargeted mutagenesis in the lacI gene of Escherichia coli.

Authors:  B A Kunz; B W Glickman
Journal:  Genetics       Date:  1984-03       Impact factor: 4.562

9.  Influence of RecA protein on induced mutagenesis.

Authors:  M Blanco; G Herrera; P Collado; J E Rebollo; L M Botella
Journal:  Biochimie       Date:  1982 Aug-Sep       Impact factor: 4.079

10.  A mutant of Escherichia coli showing constitutive expression of the lysogenic induction and error-prone DNA repair pathways.

Authors:  D W Mount
Journal:  Proc Natl Acad Sci U S A       Date:  1977-01       Impact factor: 11.205
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  6 in total

1.  Specificity of mutation by UV light and delayed photoreversal in umuC-defective Escherichia coli K-12: a targeting intermediate at pyrimidine dimers.

Authors:  R Bockrath; M Ruiz-Rubio; B A Bridges
Journal:  J Bacteriol       Date:  1987-04       Impact factor: 3.490

2.  An in vivo complex with DNA photolyase blocks UV mutagenesis targeted at a thymine-cytosine dimer in Escherichia coli.

Authors:  M Ruiz-Rubio; K Yamamoto; R Bockrath
Journal:  J Bacteriol       Date:  1988-11       Impact factor: 3.490

3.  Anti-mutagenic effect of ultraviolet light on spontaneous tyrosine tRNA ochre suppressor mutations in Escherichia coli.

Authors:  R Bockrath; M Ruiz-Rubio
Journal:  Mol Gen Genet       Date:  1988-10

4.  An inducible pathway is required for mutagenesis in Salmonella typhimurium LT2.

Authors:  C Orrego; E Eisenstadt
Journal:  J Bacteriol       Date:  1987-06       Impact factor: 3.490

5.  RecA-mediated cleavage activates UmuD for mutagenesis: mechanistic relationship between transcriptional derepression and posttranslational activation.

Authors:  T Nohmi; J R Battista; L A Dodson; G C Walker
Journal:  Proc Natl Acad Sci U S A       Date:  1988-03       Impact factor: 11.205

6.  Mutagenic DNA repair in Escherichia coli. XIV. Influence of two DNA polymerase III mutator alleles on spontaneous and UV mutagenesis.

Authors:  M Ruiz-Rubio; B A Bridges
Journal:  Mol Gen Genet       Date:  1987-07
  6 in total

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