| Literature DB >> 35194923 |
Pan-Feng Wu1,2, Juan Liu3, Ya-Nan Li1,2, Ru Ding1,2, Rong Tan4, Xiao-Meng Yang1,2, Yan Yu1,2, Xiao-Jiang Hao1,2, Chun-Mao Yuan1,2, Ping Yi1,2.
Abstract
Three new aglain derivatives (1-3), one known aglain derivative (4), two known rocaglamide derivatives (5 and 6), four known triterpenoids (7-10), and three steroids (11-13) were isolated from Aglaia odorata Lour. Their structures were established through the analysis of detailed spectroscopic data and electronic circular dichroism calculations. Five compounds (1 and 4-7) exhibited cytotoxic activities on human leukemia cells (HEL) and human breast cancer cells with IC50 values in the range of 0.03-8.40 μM. In particular, the cytotoxicity of compound 5 was six times stronger than that of the positive control (adriamycin) in HEL cell lines.Entities:
Keywords: Aglaia odorata; Meliaceae; aglain derivatives; cytotoxic activity
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Year: 2022 PMID： 35194923 DOI： 10.1002/cbdv.202101008
Source DB: PubMed Journal: Chem Biodivers ISSN： 1612-1872 Impact factor: 2.408