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Literature DB >> 3519446

A novel polymorphism of human complement component C3 detected by means of a monoclonal antibody.

Abstract

A mouse monoclonal antibody, HAV 4-1, obtained after immunization of a BALB/c mouse with purified C3F, detected a novel genetic polymorphism of human complement component C3 in a simple immunoblotting system. The frequency of HAV 4-1-positive genes was 20.1%. Reactivity of HAV 4-1 was closely related to C3F, but certain individuals with the C3F allele did not react with HAV 4-1. Conversely, certain C3S homozygous individuals did react with HAV 4-1. The polymorphism detected by this monoclonal antibody is therefore different from the previously described polymorphism based on charge differences.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1986 PMID： 3519446 DOI： 10.1007/bf00398796

Source DB: PubMed Journal: Immunogenetics ISSN： 0093-7711 Impact factor: 2.846

19 in total

1. Hypomorphic variant of C3, arthritis, and chronic glomerulonephritis.

Authors: R H McLean; A Weinstein; I Damjanov; N Rothfield
Journal: J Pediatr Date: 1978-12 Impact factor: 4.406

2. Capacity of complement c3 phenotypes to bind on to mononuclear cells in man.

Authors: H Arvilommi
Journal: Nature Date: 1974-10-25 Impact factor: 49.962

3. Studies of the C3 polymorphism. Rlationship between C3 phenotypes and rheumatoid arthritis.

Authors: R Brönnestam
Journal: Hum Hered Date: 1973 Impact factor: 0.444

4. C3 polymorphism in a group of old arteriosclerotic patients.

Authors: J Dissing; J Lund; H Sorensen
Journal: Hum Hered Date: 1972 Impact factor: 0.444

5. The molecular basis for isozymes.

Authors: C L Markert
Journal: Ann N Y Acad Sci Date: 1968-06-14 Impact factor: 5.691

6. Allotypes of C3 in laboratory and wild mouse distinguished by alloantisera.

Authors: S Natsuume-Sakai; K Moriwaki; S Amano; J Hayakawa; T Kaidoh; M Takahashi
Journal: J Immunol Date: 1979-07 Impact factor: 5.422

7. Linkage between familial hypercholesterolemia with xanthomatosis and the C3 polymorphism confirmed.

Authors: K Berg; A Heiberg
Journal: Cytogenet Cell Genet Date: 1978

Review 8. Membrane attack by complement.

Authors: E R Podack; J Tschopp
Journal: Mol Immunol Date: 1984-07 Impact factor: 4.407

A novel polymorphism of human complement component C3 detected by means of a monoclonal antibody.

1. Hypomorphic variant of C3, arthritis, and chronic glomerulonephritis.

2. Capacity of complement c3 phenotypes to bind on to mononuclear cells in man.

3. Studies of the C3 polymorphism. Rlationship between C3 phenotypes and rheumatoid arthritis.

4. C3 polymorphism in a group of old arteriosclerotic patients.

5. The molecular basis for isozymes.

6. Allotypes of C3 in laboratory and wild mouse distinguished by alloantisera.

7. Linkage between familial hypercholesterolemia with xanthomatosis and the C3 polymorphism confirmed.

Review 8. Membrane attack by complement.

Review 9. The proteolytic activation systems of complement.

10. Linkage analysis of myotonic dystrophy and sequences on chromosome 19 using a cloned complement 3 gene probe.

1. A novel protein polymorphism of human complement C7 detected by a monoclonal antibody.

2. Molecular analysis of C3 allotypes in patients with nephritic factor.

Review 3. The role of the alternative pathway of complement activation in glomerular diseases.

4. Molecular basis of polymorphisms of human complement component C3.