| Literature DB >> 35194127 |
Philippe Voruz1,2, Jordan Pierce1, Kévin Ahrweiller3,4, Claire Haegelen5,6, Paul Sauleau3,7, Sophie Drapier3,4, Dominique Drapier3,8, Marc Vérin3,4, Julie Péron9,10,11.
Abstract
Risk factors for long-term non-motor symptoms and quality of life following subthalamic nucleus deep brain stimulation (STN DBS) have not yet been fully identified. In the present study, we investigated the impact of motor symptom asymmetry in Parkinson's disease. Data were extracted for 52 patients with Parkinson's disease (half with predominantly left-sided motor symptoms and half with predominantly right-sided ones) who underwent bilateral STN and a matched healthy control group. Performances for cognitive tests, apathy and depression symptoms, as well as quality-of-life questionnaires at 12 months post-DBS were compared with a pre-DBS baseline. Results indicated a deterioration in cognitive performance post-DBS in patients with predominantly left-sided motor symptoms. Performances of patients with predominantly right-sided motor symptoms were maintained, except for a verbal executive task. These differential effects had an impact on patients' quality of life. The results highlight the existence of two distinct cognitive profiles of Parkinson's disease, depending on motor symptom asymmetry. This asymmetry is a potential risk factor for non-motor adverse effects following STN DBS.Entities:
Mesh：
Year: 2022 PMID： 35194127 PMCID： PMC8863787 DOI： 10.1038/s41598-022-07026-5
Source DB: PubMed Journal: Sci Rep ISSN： 2045-2322 Impact factor: 4.996