See Wan Tham1, Fuchenchu Wang2, Cheryl E Gariepy3, Gretchen A Cress4, Maisam A Abu-El-Haija5, Melena D Bellin6, Kate M Ellery7, Douglas S Fishman8, Tanja Gonska9, Melvin B Heyman10, Tom K Lin5, Asim Maqbool11, Brian A McFerron12, Veronique D Morinville13, Jaimie D Nathan3, Chee Y Ooi14, Emily R Perito10, Sarah Jane Schwarzenberg6, Zachary M Sellers15, Uzma Shah16, David M Troendle17, Michael Wilschanski18, Yuhua Zheng19, Ying Yuan2, Mark E Lowe20, Aliye Uc4, Tonya M Palermo1. 1. Department of Anesthesiology & Pain Medicine, University of Washington School of Medicine, Seattle, WA. 2. The University of Texas, MD Anderson Cancer Center, Houston, TX. 3. Nationwide Children's Hospital, Columbus, OH. 4. University of Iowa, Stead Family Children's Hospital, Iowa City, IA. 5. Cincinnati Children's Hospital Medical Center, College of Medicine, University of Cincinnati, Cincinnati, OH. 6. University of Minnesota Masonic Children's Hospital, Minneapolis, MN. 7. UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA. 8. Division of Pediatric Gastroenterology, Hepatology and Nutrition, Baylor College of Medicine and Texas Children's Hospital, Houston, TX. 9. Hospital for Sick Children, Toronto, ON, Canada. 10. University of California San Francisco, San Francisco, CA. 11. Children's Hospital of Philadelphia, Philadelphia, PA. 12. Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN. 13. Montreal Children's Hospital, McGill University, Montreal, QC. 14. School of Women's and Children's Health, Faculty of Medicine, University of New South Wales and Department of Gastroenterology, Sydney Children's Hospital Randwick, Sydney, NSW, Australia. 15. Stanford University, Stanford Children's Health, Palo Alto, CA. 16. Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA. 17. University of Texas Southwestern Medical School, Dallas, TX. 18. Hadassah Hebrew University Hospital, Jerusalem, Israel. 19. Children's Hospital Los Angeles, Los Angeles, CA. 20. Washington University School of Medicine, St. Louis, MO.
Abstract
OBJECTIVES: Abdominal pain, emergency department visits, and hospitalizations impact lives of children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP). Data on health-related quality of life (HRQOL) in this population, however, remains limited. We aimed to evaluate HRQOL in children with ARP or CP; and test biopsychosocial risk factors associated with low HRQOL. METHODS: Data were acquired from the INternational Study Group of Pediatric Pancreatitis: In search for a cuRE registry. Baseline demographic and clinical questionnaires, the Child Health Questionnaire (measures HRQOL) and Child Behavior Checklist (measures emotional and behavioral functioning) were completed at enrollment. RESULTS: The sample included 368 children (54.3% girls, mean age = 12.7years, standard deviation [SD] = 3.3); 65.2% had ARP and 34.8% with CP. Low physical HRQOL (M = 38.5, SD = 16.0) was demonstrated while psychosocial HRQOL (M = 49.5, SD = 10.2) was in the normative range. Multivariate regression analysis revealed that clinical levels of emotional and behavioral problems (B = -10.28, P < 0.001), episodic and constant abdominal pain (B = 04.66, P = 0.03; B = -13.25, P < 0.001) were associated with low physical HRQOL, after accounting for ARP/CP status, age, sex, exocrine, and endocrine disease (F [9, 271] = 8.34, P < 0.001). Borderline and clinical levels of emotional and behavioral problems (B = -10.18, P < 0.001; B = -15.98, P < 0.001), and constant pain (B = -4.46, P < 0.001) were associated with low psychosocial HRQOL (F [9, 271] = 17.18, P < 0.001). CONCLUSIONS: Findings highlight the importance of assessing HRQOL and treating pain and psychosocial problems in this vulnerable group of children.
OBJECTIVES: Abdominal pain, emergency department visits, and hospitalizations impact lives of children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP). Data on health-related quality of life (HRQOL) in this population, however, remains limited. We aimed to evaluate HRQOL in children with ARP or CP; and test biopsychosocial risk factors associated with low HRQOL. METHODS: Data were acquired from the INternational Study Group of Pediatric Pancreatitis: In search for a cuRE registry. Baseline demographic and clinical questionnaires, the Child Health Questionnaire (measures HRQOL) and Child Behavior Checklist (measures emotional and behavioral functioning) were completed at enrollment. RESULTS: The sample included 368 children (54.3% girls, mean age = 12.7years, standard deviation [SD] = 3.3); 65.2% had ARP and 34.8% with CP. Low physical HRQOL (M = 38.5, SD = 16.0) was demonstrated while psychosocial HRQOL (M = 49.5, SD = 10.2) was in the normative range. Multivariate regression analysis revealed that clinical levels of emotional and behavioral problems (B = -10.28, P < 0.001), episodic and constant abdominal pain (B = 04.66, P = 0.03; B = -13.25, P < 0.001) were associated with low physical HRQOL, after accounting for ARP/CP status, age, sex, exocrine, and endocrine disease (F [9, 271] = 8.34, P < 0.001). Borderline and clinical levels of emotional and behavioral problems (B = -10.18, P < 0.001; B = -15.98, P < 0.001), and constant pain (B = -4.46, P < 0.001) were associated with low psychosocial HRQOL (F [9, 271] = 17.18, P < 0.001). CONCLUSIONS: Findings highlight the importance of assessing HRQOL and treating pain and psychosocial problems in this vulnerable group of children.
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Authors: Wendy E Balliet; Shenelle Edwards-Hampton; Jeffery J Borckardt; Katherine Morgan; David Adams; Stefanie Owczarski; Alok Madan; Sarah K Galloway; Eva R Serber; Robert Malcolm Journal: Pain Res Treat Date: 2012-11-27