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Literature DB >> 3519244

Effect of an alpha-glucosidase inhibitor (BAY m 1099) on post-prandial blood glucose and insulin in type II diabetics.

Abstract

The effect of a new alpha-glucosidase inhibitor (BAY m 1099), a 1-deoxynojirimycin derivative, was studied in 10 black patients with Type II diabetes mellitus. It produced significant lowering of blood glucose concentration after standardized maize porridge meals. No significant untoward effects were noted. BAY m 1099 appears to offer potential benefit in the management of Type II diabetics, and more extensive clinical investigation is warranted.

Entities: Chemical Disease Gene Species

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Year: 1986 PMID： 3519244 DOI： 10.1007/bf00614315

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

3 in total

1. [Glucosidase inhibitors from Bacilli].

Authors: D D Schmidt; W Frommer; L Müller; E Truscheit
Journal: Naturwissenschaften Date: 1979-11

2. The effect of a 1-deoxynojirimycin derivative on post-prandial blood glucose and insulin levels in healthy black and white volunteers.

Authors: P H Joubert; C P Venter; H F Joubert; I Hillebrand
Journal: Eur J Clin Pharmacol Date: 1985 Impact factor: 2.953

3. Inhibition of N-linked complex oligosaccharide formation by 1-deoxynojirimycin, an inhibitor of processing glucosidases.

Authors: B Saunier; R D Kilker; J S Tkacz; A Quaroni; A Herscovics
Journal: J Biol Chem Date: 1982-12-10 Impact factor: 5.157

3 in total

4 in total

4. Loss of cytomegalovirus infectivity after treatment with castanospermine or related plant alkaloids correlates with aberrant glycoprotein synthesis.

Authors: D L Taylor; L E Fellows; G H Farrar; R J Nash; D Taylor-Robinson; M A Mobberley; T A Ryder; D J Jeffries; A S Tyms
Journal: Antiviral Res Date: 1988-11 Impact factor: 5.970

4 in total

Effect of an alpha-glucosidase inhibitor (BAY m 1099) on post-prandial blood glucose and insulin in type II diabetics.

1. [Glucosidase inhibitors from Bacilli].

2. The effect of a 1-deoxynojirimycin derivative on post-prandial blood glucose and insulin levels in healthy black and white volunteers.

3. Inhibition of N-linked complex oligosaccharide formation by 1-deoxynojirimycin, an inhibitor of processing glucosidases.

Review 1. Miglitol: a review of its therapeutic potential in type 2 diabetes mellitus.

2. The effect of two new glucosidase inhibitors on blood glucose in healthy volunteers and in type II diabetics.

3. Investigation on the Enzymatic Profile of Mulberry Alkaloids by Enzymatic Study and Molecular Docking.

4. Loss of cytomegalovirus infectivity after treatment with castanospermine or related plant alkaloids correlates with aberrant glycoprotein synthesis.