Ole B Pedersen1, Gregor B E Jemec2, Mattias A S Henning3, Kristina S Ibler2, Isabella Loft1, Sisse R Ostrowski4, Christian Erikstrup5, Kaspar R Nielsen6, Mie T Bruun7, Henrik Ullum8, Maria Didriksen4, Khoa M Dinh5. 1. Department of Clinical Immunology, Zealand University Hospital, Næstved, Denmark. 2. Department of Dermatology, Zealand University Hospital, Roskilde, Denmark. 3. Department of Dermatology, Zealand University Hospital, Roskilde, Denmark. maahe@regionsjaelland.dk. 4. Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark. 5. Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark. 6. Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark. 7. Department of Clinical Immunology, Odense University Hospital, Odense, Denmark. 8. Statens Serum Institute, Copenhagen, Denmark.
Abstract
PURPOSE: Hyperhidrosis has been associated with a reduced health-related quality of life (HRQoL). The role of common confounding factors of this association such as stress and socioeconomic status, however, remain largely unexplored, and may affect the management strategy for hyperhidrosis. Therefore, the study objective was to compare the HRQoL in individuals with and without hyperhidrosis while adjusting for confounders. METHODS: In this retrospective cohort study, data on the HRQoL measured by the short-form-12 questionnaire and self-reported hyperhidrosis were collected from the Danish Blood Donor Study-cohort. Data on international classification of disease-10 codes and redeemed prescriptions were collected from nationwide registries. Linear regression investigated the association between hyperhidrosis and HRQoL. RESULTS: Total 2794 (9.1%) of 30,808 blood donors had self-reported hyperhidrosis and 284 (0.2%) of 122,225 had hospital diagnosed hyperhidrosis. Self-reported hyperhidrosis was associated with a reduced mental HRQoL (adjusted beta coefficient - 1.10; 95% confidence interval - 1.37, - 0.82; p < 0.001) and physical HRQoL (adjusted beta coefficient - 0.90; 95% confidence interval - 1.09, - 0.70; p < 0.001). Hospital diagnosed hyperhidrosis was associated with a reduced mental HRQoL (adjusted beta coefficient - 0.91; 95% confidence interval - 1.82, - 0.04; p = 0.049). CONCLUSION: Hyperhidrosis is associated with a reduced HRQoL, independently of confounders or mode of diagnosis. This supports an approach primarily targeting hyperhidrosis.
PURPOSE: Hyperhidrosis has been associated with a reduced health-related quality of life (HRQoL). The role of common confounding factors of this association such as stress and socioeconomic status, however, remain largely unexplored, and may affect the management strategy for hyperhidrosis. Therefore, the study objective was to compare the HRQoL in individuals with and without hyperhidrosis while adjusting for confounders. METHODS: In this retrospective cohort study, data on the HRQoL measured by the short-form-12 questionnaire and self-reported hyperhidrosis were collected from the Danish Blood Donor Study-cohort. Data on international classification of disease-10 codes and redeemed prescriptions were collected from nationwide registries. Linear regression investigated the association between hyperhidrosis and HRQoL. RESULTS: Total 2794 (9.1%) of 30,808 blood donors had self-reported hyperhidrosis and 284 (0.2%) of 122,225 had hospital diagnosed hyperhidrosis. Self-reported hyperhidrosis was associated with a reduced mental HRQoL (adjusted beta coefficient - 1.10; 95% confidence interval - 1.37, - 0.82; p < 0.001) and physical HRQoL (adjusted beta coefficient - 0.90; 95% confidence interval - 1.09, - 0.70; p < 0.001). Hospital diagnosed hyperhidrosis was associated with a reduced mental HRQoL (adjusted beta coefficient - 0.91; 95% confidence interval - 1.82, - 0.04; p = 0.049). CONCLUSION: Hyperhidrosis is associated with a reduced HRQoL, independently of confounders or mode of diagnosis. This supports an approach primarily targeting hyperhidrosis.
Authors: John Hornberger; Kevin Grimes; Markus Naumann; Dee Anna Glaser; Nicholas J Lowe; Hans Naver; Samuel Ahn; Lewis P Stolman Journal: J Am Acad Dermatol Date: 2004-08 Impact factor: 11.527
Authors: Hassan A Tetteh; Shawn S Groth; Teri Kast; Bryan A Whitson; David M Radosevich; Amy C Klopp; Jonathan D'Cunha; Michael A Maddaus; Rafael S Andrade Journal: Ann Thorac Surg Date: 2009-01 Impact factor: 4.330
Authors: Mattias A S Henning; Kristina S Ibler; Isabella Loft; Henrik Ullum; Christian Erikstrup; Kaspar R Nielsen; Mie Topholm Bruun; Henrik Hjalgrim; Erik Sørensen; Kristoffer S Burgdorf; Susan Mikkelsen; Thomas F Hansen; Ole B Pedersen; Gregor B E Jemec Journal: Acta Derm Venereol Date: 2021-04-26 Impact factor: 3.875
Authors: Katharina M Gross; Andrea B Schote; Katja Kerstin Schneider; André Schulz; Jobst Meyer Journal: PLoS One Date: 2014-03-19 Impact factor: 3.240