Linlin Miao1, Xiaofan Guo1, Guozhe Sun1, Yinglong Bai2, Yingxian Sun1, Zhao Li1. 1. Department of Cardiology, the First Hospital of China Medical University; Shenyang-China. 2. Department of Maternal and Child Health, School of Public Health, China Medical University; Shenyang-China.
Abstract
OBJECTIVE: Previous studies have investigated the relationship between alcohol and ventricular structure; however, few studies have evaluated the relation between alcohol consumption and the atrium size. In this study, we aimed to test the association between alcohol consumption and left atrium (LA) size in the general population. METHODS: A population-based sample of 10,211 subjects aged ≥35 years and free from hypertension at baseline were followed from January 2012 to August 2013. Left atrial enlargement (LAE) was defined as the ratio of LA diameter to body surface area exceeding 2.4 cm/m2 in both the sexes. Independent factors for LAE were estimated by multiple logistic regression analyses. RESULTS: The study included 10,211 participants (4,751 men and 5,460 women). Left atrial diameter/body surface area (LAD/BSA) was higher in the moderate and heavy alcohol consumption groups than in the non-drinker group (non-drinker, 20.5±0.03 cm/m2; moderate, 20.8±0.09 cm/m2; and heavy, 20.6±0.06 cm/m2; p<0.001). Both the groups of moderate and heavy drinkers had a higher incidence of LAE than the non-drinker group (6.9% of non-drinkers, 9.9% of moderate drinkers, and 8.4% of heavy drinkers; p<0.001). After adjusting for related risk factors, multiple logistic regression analyses showed that moderate drinkers had an approximately 1.4-fold higher risk of LAE [odds ratio (OR): 1.387, 95% confidence interval (CI) 1.056-1.822, p=0.019] compared with the non-drinkers, and the heavy drinkers had an approximately 1.2-fold higher risk of LAE (OR: 1.229, 95% CI: 1.002-1.508, p=0.047) compared with that of the non-drinkers. CONCLUSION: Both heavy and moderate drinkers had increased odds for LAE compared with participants with no alcohol consumption in the general population.
OBJECTIVE: Previous studies have investigated the relationship between alcohol and ventricular structure; however, few studies have evaluated the relation between alcohol consumption and the atrium size. In this study, we aimed to test the association between alcohol consumption and left atrium (LA) size in the general population. METHODS: A population-based sample of 10,211 subjects aged ≥35 years and free from hypertension at baseline were followed from January 2012 to August 2013. Left atrial enlargement (LAE) was defined as the ratio of LA diameter to body surface area exceeding 2.4 cm/m2 in both the sexes. Independent factors for LAE were estimated by multiple logistic regression analyses. RESULTS: The study included 10,211 participants (4,751 men and 5,460 women). Left atrial diameter/body surface area (LAD/BSA) was higher in the moderate and heavy alcohol consumption groups than in the non-drinker group (non-drinker, 20.5±0.03 cm/m2; moderate, 20.8±0.09 cm/m2; and heavy, 20.6±0.06 cm/m2; p<0.001). Both the groups of moderate and heavy drinkers had a higher incidence of LAE than the non-drinker group (6.9% of non-drinkers, 9.9% of moderate drinkers, and 8.4% of heavy drinkers; p<0.001). After adjusting for related risk factors, multiple logistic regression analyses showed that moderate drinkers had an approximately 1.4-fold higher risk of LAE [odds ratio (OR): 1.387, 95% confidence interval (CI) 1.056-1.822, p=0.019] compared with the non-drinkers, and the heavy drinkers had an approximately 1.2-fold higher risk of LAE (OR: 1.229, 95% CI: 1.002-1.508, p=0.047) compared with that of the non-drinkers. CONCLUSION: Both heavy and moderate drinkers had increased odds for LAE compared with participants with no alcohol consumption in the general population.
Authors: Walter P Abhayaratna; James B Seward; Christopher P Appleton; Pamela S Douglas; Jae K Oh; A Jamil Tajik; Teresa S M Tsang Journal: J Am Coll Cardiol Date: 2006-06-20 Impact factor: 24.094
Authors: Joseph A Walsh; Leonard Ilkhanoff; Elsayed Z Soliman; Ronald Prineas; Kiang Liu; Hongyan Ning; Donald M Lloyd-Jones Journal: J Am Coll Cardiol Date: 2013-02-26 Impact factor: 24.094
Authors: Osvaldo P Almeida; Kieran McCaul; Graeme J Hankey; Bu B Yeap; Jonathan Golledge; Leon Flicker Journal: Addict Biol Date: 2015-12-08 Impact factor: 4.280
Authors: Martin Bobak; Sofia Malyutina; Pia Horvat; Andrzej Pajak; Abdonas Tamosiunas; Ruzena Kubinova; Galina Simonova; Roman Topor-Madry; Anne Peasey; Hynek Pikhart; Michael G Marmot Journal: Eur J Epidemiol Date: 2015-10-14 Impact factor: 8.082
Authors: David D McManus; Xiaoyan Yin; Rachel Gladstone; Eric Vittinghoff; Ramachandran S Vasan; Martin G Larson; Emelia J Benjamin; Gregory M Marcus Journal: J Am Heart Assoc Date: 2016-09-14 Impact factor: 5.501