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Literature DB >> 3519026

Nephrotoxicity of cyclosporine in spontaneously hypertensive rats: effects on blood pressure and vascular lesions.

B Ryffel, H Siegl, R Petric, A M Muller, R Hauser, M J Mihatsch.

Abstract

Cyclosporine (CSA) caused functional and morphologic renal changes in spontaneously hypertensive rats. The development of hypertensive arterial lesions were accelerated by CSA. Blood pressure was significantly increased especially in young rats. The influence of age of the animals, dose and duration of CSA administration on the development of vascular lesions and blood pressure was investigated.

Entities: Chemical Disease Species

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Year: 1986 PMID： 3519026

Source DB: PubMed Journal: Clin Nephrol ISSN： 0301-0430 Impact factor: 0.975

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Cited

11 in total

1. Ultrastructure of rat aortic grafts.

Authors: P Rossmann; J Lácha
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Review 2. Cardiac transplantation. Selection, immunosuppression, and survival.

Authors: L W Stevenson; H Laks; P I Terasaki; B D Kahan; D C Drinkwater
Journal: West J Med Date: 1988-11

3. Reciprocal regulation of cyclic GMP content by cyclic GMP-phosphodiesterase and guanylate cyclase in SHR with CsA-induced nephrotoxicity.

Authors: N Hosogai; J Seki; T Goto
Journal: Br J Pharmacol Date: 2001-11 Impact factor: 8.739

Nephrotoxicity of cyclosporine in spontaneously hypertensive rats: effects on blood pressure and vascular lesions.

1. Ultrastructure of rat aortic grafts.

Review 2. Cardiac transplantation. Selection, immunosuppression, and survival.

3. Reciprocal regulation of cyclic GMP content by cyclic GMP-phosphodiesterase and guanylate cyclase in SHR with CsA-induced nephrotoxicity.

4. Influence of enalapril on experimental cyclosporin A nephrotoxicity.

Review 5. Antibody-targeted polymer-bound drugs.

Review 6. Morphology and immunohistochemistry of rat aortic grafts.

7. Cyclosporine-induced nephrotoxicity in deoxycorticosterone-NaCl treated rats.

8. Cyclosporin A-induced nephrotoxicity in the rat: relationship to increased plasma renin activity.

9. Renal injury induced by long-term administration of cyclosporin A to rats.

10. [Effect of enalapril, furosemide and verapamil on cyclosporin concentration in whole blood].