Literature DB >> 3519008

Does melatonin deficiency cause the enlarged genitalia of the fragile-X syndrome?

J P O'Hare, I A O'Brien, J Arendt, P Astley, W Ratcliffe, H Andrews, R Walters, R J Corrall.   

Abstract

Melatonin profiles were studied in five males with cytogenetic and clinical features of the fragile-X syndrome including megalo-orchidia and macrogenitosomia. In comparison with age-matched normal controls, the fragile-X group showed lower melatonin values and a significant impairment of the nocturnal rise in this hormone. Melatonin deficiency may thus be responsible for some of the phenotypic features of this disorder.

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Year:  1986        PMID： 3519008     DOI： 10.1111/j.1365-2265.1986.tb03274.x

Source DB:  PubMed          Journal:  Clin Endocrinol (Oxf)        ISSN： 0300-0664            Impact factor:   3.478


  6 in total

Review 1.  Genetics of narcolepsy and other sleep disorders.

Authors:  E Mignot
Journal:  Am J Hum Genet       Date:  1997-06       Impact factor: 11.025

Review 2.  Fragile X syndrome. Molecular and clinical insights and treatment issues.

Authors:  R J Hagerman
Journal:  West J Med       Date:  1997-02

3.  The efficacy of melatonin for sleep problems in children with autism, fragile X syndrome, or autism and fragile X syndrome.

Authors:  Juthamas Wirojanan; Sebastien Jacquemont; Rafael Diaz; Susan Bacalman; Thomas F Anders; Randi J Hagerman; Beth L Goodlin-Jones
Journal:  J Clin Sleep Med       Date:  2009-04-15       Impact factor: 4.062

4.  Thyroid function in fragile-X syndrome males.

Authors:  J D Bregman; J F Leckman; S I Ort
Journal:  Yale J Biol Med       Date:  1990 Jul-Aug

Review 5.  Melatonin as a Novel Interventional Candidate for Fragile X Syndrome with Autism Spectrum Disorder in Humans.

Authors:  Jinyoung Won; Yunho Jin; Jeonghyun Choi; Sookyoung Park; Tae Ho Lee; Sang-Rae Lee; Kyu-Tae Chang; Yonggeun Hong
Journal:  Int J Mol Sci       Date:  2017-06-20       Impact factor: 5.923

6.  Feasibility of a Complex Setting for Assessing Sleep and Circadian Rhythmicity in a Fragile X Cohort.

Authors:  Alexander Dueck; Olaf Reis; Manuela Bastian; Lucas van Treeck; Steffen Weirich; Frank Haessler; Andreas Fiedler; Michael Koelch; Christoph Berger
Journal:  Front Psychiatry       Date:  2020-05-14       Impact factor: 4.157
  6 in total

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