Literature DB >> 35187420

Epidrugs in Amyotrophic Lateral Sclerosis/Frontotemporal Dementia: Contextualizing a Role for Histone Kinase Inhibition in Neurodegenerative Disease.

Samantha N Cobos1,2, Mariana P Torrente1,2,3,4.   

Abstract

Breakthroughs in understanding the epigenetic mechanisms involved in neurodegenerative disease have highlighted "epidrugs" as a potential avenue for therapeutic development. Here, we expand on the future of epidrugs against neurodegeneration and discuss promising novel targets underexploited thus far: histone kinases.
© 2022 American Chemical Society.

Entities:  

Year:  2022        PMID： 35187420      PMCID： PMC8844958          DOI： 10.1021/acsptsci.1c00265

Source DB:  PubMed          Journal:  ACS Pharmacol Transl Sci        ISSN： 2575-9108


  37 in total

1.  R loops are linked to histone H3 S10 phosphorylation and chromatin condensation.

Authors:  Maikel Castellano-Pozo; José M Santos-Pereira; Ana G Rondón; Sonia Barroso; Eloisa Andújar; Mónica Pérez-Alegre; Tatiana García-Muse; Andrés Aguilera
Journal:  Mol Cell       Date:  2013-11-07       Impact factor: 17.970

Review 2.  Regulation of chromatin by histone modifications.

Authors:  Andrew J Bannister; Tony Kouzarides
Journal:  Cell Res       Date:  2011-02-15       Impact factor: 25.617

Review 3.  ATM in DNA repair in cancer.

Authors:  Mei Hua Jin; Do-Youn Oh
Journal:  Pharmacol Ther       Date:  2019-07-09       Impact factor: 12.310

4.  The DNA damage response (DDR) is induced by the C9orf72 repeat expansion in amyotrophic lateral sclerosis.

Authors:  Manal A Farg; Anna Konopka; Kai Ying Soo; Daisuke Ito; Julie D Atkin
Journal:  Hum Mol Genet       Date:  2017-08-01       Impact factor: 6.150

5.  MAP4K4 Activation Mediates Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis.

Authors:  Chen Wu; Michelle E Watts; Lee L Rubin
Journal:  Cell Rep       Date:  2019-01-29       Impact factor: 9.423

6.  Treatment with trichostatin A initiated after disease onset delays disease progression and increases survival in a mouse model of amyotrophic lateral sclerosis.

Authors:  Young-Eun Yoo; Chien-Ping Ko
Journal:  Exp Neurol       Date:  2011-06-25       Impact factor: 5.330

Review 7.  Mitogen-Activated Protein Kinase Pathway in Amyotrophic Lateral Sclerosis.

Authors:  T G Sahana; Ke Zhang
Journal:  Biomedicines       Date:  2021-08-06

Review 8.  Casein kinases as potential therapeutic targets.

Authors:  Giorgio Cozza; Lorenzo A Pinna
Journal:  Expert Opin Ther Targets       Date:  2015-11-13       Impact factor: 6.902

9.  Neurodegenerative Disease Proteinopathies Are Connected to Distinct Histone Post-translational Modification Landscapes.

Authors:  Karen Chen; Seth A Bennett; Navin Rana; Huda Yousuf; Mohamed Said; Sadiqa Taaseen; Natalie Mendo; Steven M Meltser; Mariana P Torrente
Journal:  ACS Chem Neurosci       Date:  2018-01-08       Impact factor: 4.418

10.  The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint.

Authors:  Silke Hauf; Richard W Cole; Sabrina LaTerra; Christine Zimmer; Gisela Schnapp; Rainer Walter; Armin Heckel; Jacques van Meel; Conly L Rieder; Jan-Michael Peters
Journal:  J Cell Biol       Date:  2003-04-21       Impact factor: 10.539
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  2 in total

1.  Virtual Special Issue: Epigenetics 2022.

Authors:  Courtney C Aldrich; Félix Calderón; Stuart J Conway; Chuan He; Jacob M Hooker; Donna M Huryn; Craig W Lindsley; Dennis C Liotta; Christa E Müller
Journal:  ACS Pharmacol Transl Sci       Date:  2022-09-09

2.  Virtual Special Issue: Epigenetics 2022.

Authors:  Courtney C Aldrich; Félix Calderón; Stuart J Conway; Chuan He; Jacob M Hooker; Donna M Huryn; Craig W Lindsley; Dennis C Liotta; Christa E Müller
Journal:  ACS Med Chem Lett       Date:  2022-10-13       Impact factor: 4.632
  2 in total

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