Literature DB >> 3518719

ADP-ribosylation of nonmuscle actin with component I of C2 toxin.

I Ohishi, S Tsuyama.   

Abstract

C2 toxin elaborated by Clostridium botulinum type C is composed of two dissimilar protein components, designated components I and II. Component I of the toxin caused ADP-ribosylation of a protein of Mr 45,000 in chicken tissue homogenates and also purified nonmuscle but not muscle actin. The endogenous ADP-ribosylation of intracellular actin with C2 toxin was correlated with the morphological change in intact culture cells caused by the toxin. These results indicate that the biological activity of the toxin involves a novel enzymatic activity of component I, which catalyzes the preferential ADP-ribosylation of nonmuscle actin of the target cells.

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Year:  1986        PMID： 3518719     DOI： 10.1016/0006-291x(86)90511-5

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  18 in total

1.  Visualizations of binding and internalization of two nonlinked protein components of botulinum C2 toxin in tissue culture cells.

Authors:  I Ohishi; A Yanagimoto
Journal:  Infect Immun       Date:  1992-11       Impact factor: 3.441

2.  Production by Clostridium spiroforme of an iotalike toxin that possesses mono(ADP-ribosyl)transferase activity: identification of a novel class of ADP-ribosyltransferases.

Authors:  L L Simpson; B G Stiles; H Zepeda; T D Wilkins
Journal:  Infect Immun       Date:  1989-01       Impact factor: 3.441

Review 3.  Toxigenic clostridia.

Authors:  C L Hatheway
Journal:  Clin Microbiol Rev       Date:  1990-01       Impact factor: 26.132

4.  Partial characterization of the enzymatic activity associated with the binary toxin (type C2) produced by Clostridium botulinum.

Authors:  L L Simpson; H Zepeda; I Ohishi
Journal:  Infect Immun       Date:  1988-01       Impact factor: 3.441

5.  Membrane translocation of binary actin-ADP-ribosylating toxins from Clostridium difficile and Clostridium perfringens is facilitated by cyclophilin A and Hsp90.

Authors:  Eva Kaiser; Claudia Kroll; Katharina Ernst; Carsten Schwan; Michel Popoff; Gunter Fischer; Johannes Buchner; Klaus Aktories; Holger Barth
Journal:  Infect Immun       Date:  2011-07-18       Impact factor: 3.441

Review 6.  Proteolytic activation of bacterial toxins: role of bacterial and host cell proteases.

Authors:  V M Gordon; S H Leppla
Journal:  Infect Immun       Date:  1994-02       Impact factor: 3.441

Review 7.  Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins.

Authors:  Holger Barth; Klaus Aktories; Michel R Popoff; Bradley G Stiles
Journal:  Microbiol Mol Biol Rev       Date:  2004-09       Impact factor: 11.056

8.  ADP-ribosylation of rainbow trout (Oncorhynchus mykiss) actin by botulinum C2 toxin.

Authors:  H Kodama; I Ohishi
Journal:  Infect Immun       Date:  1993-12       Impact factor: 3.441

9.  Actin-specific ADP-ribosyltransferase produced by a Clostridium difficile strain.

Authors:  M R Popoff; E J Rubin; D M Gill; P Boquet
Journal:  Infect Immun       Date:  1988-09       Impact factor: 3.441

10.  Purification and characterization of Clostridium perfringens iota toxin: dependence on two nonlinked proteins for biological activity.

Authors:  B G Stiles; T D Wilkins
Journal:  Infect Immun       Date:  1986-12       Impact factor: 3.441
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