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Literature DB >> 3518704

Elastinolytic activity of human cathepsin L.

R W Mason, D A Johnson, A J Barrett, H A Chapman.

Abstract

The hydrolysis of a tritiated elastin substrate by the human cysteine proteinases cathepsins B and L has been studied. Cathepsin L was found to be at least 100-fold more active on this substrate than cathepsin B. The specific activity of cathepsin L at pH 5.5 for hydrolysis of elastin was about the same as that of pig pancreatic elastase at its optimum pH of 8.8.

Entities: Gene Species

Mesh：

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Year: 1986 PMID： 3518704 PMCID： PMC1153120 DOI： 10.1042/bj2330925

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

15 in total

1. p-Nitrophenyl-p'-guanidinobenzoate HCl: a new active site titrant for trypsin.

Authors: T Chase; E Shaw
Journal: Biochem Biophys Res Commun Date: 1967-11-30 Impact factor: 3.575

2. Human lysosomal elastase. Catalytic and immunological properties.

Authors: P M Starkey; A J Barrett
Journal: Biochem J Date: 1976-05-01 Impact factor: 3.857

3. Co-operation between plasmin and elastase in elastin degradation by intact murine macrophages.

Authors: H A Chapman; O L Stone
Journal: Biochem J Date: 1984-09-15 Impact factor: 3.857

Review 4. Cathepsin B, Cathepsin H, and cathepsin L.

Authors: A J Barrett; H Kirschke
Journal: Methods Enzymol Date: 1981 Impact factor: 1.600

5. Rapid interaction of cathepsin L by Z-Phe-PheCHN12 and Z-Phe-AlaCHN2.

Authors: H Kirschke; E Shaw
Journal: Biochem Biophys Res Commun Date: 1981-07-30 Impact factor: 3.575

6. Human liver cathepsin L.

Authors: R W Mason; G D Green; A J Barrett
Journal: Biochem J Date: 1985-02-15 Impact factor: 3.857

7. Comparison of live human neutrophil and alveolar macrophage elastolytic activity in vitro. Relative resistance of macrophage elastolytic activity to serum and alveolar proteinase inhibitors.

Authors: H A Chapman; O L Stone
Journal: J Clin Invest Date: 1984-11 Impact factor: 14.808

8. Calpain inhibition by peptide epoxides.

Authors: C Parkes; A A Kembhavi; A J Barrett
Journal: Biochem J Date: 1985-09-01 Impact factor: 3.857

9. Cathepsin B-like cysteine proteinase activity in sputum and bronchoalveolar lavage samples: relationship to inflammatory cells and effects of corticosteroids and antibiotic treatment.

Authors: D Burnett; R A Stockley
Journal: Clin Sci (Lond) Date: 1985-04 Impact factor: 6.124

10. Cathepsin B-like cysteine proteinase activity in sputum and immunohistologic identification of cathepsin B in alveolar macrophages.

Authors: D Burnett; J Crocker; R A Stockley
Journal: Am Rev Respir Dis Date: 1983-11

39 in total

1. Cathepsin-L, a key molecule in the pathogenesis of drug-induced and I-cell disease-mediated gingival overgrowth: a study with cathepsin-L-deficient mice.

Authors: Fusanori Nishimura; Hisa Naruishi; Koji Naruishi; Teruo Yamada; Junzo Sasaki; Christoph Peters; Yasuo Uchiyama; Yoji Murayama
Journal: Am J Pathol Date: 2002-12 Impact factor: 4.307

2. An approach to computer-aided inhibitor design: application to cathepsin L.

Authors: S Sudarsanam; G D Virca; C J March; S Srinivasan
Journal: J Comput Aided Mol Des Date: 1992-06 Impact factor: 3.686

3. Pathogenesis of aortic dilatation in mucopolysaccharidosis VII mice may involve complement activation.

Authors: Guilherme Baldo; Susan Wu; Ruth A Howe; Meera Ramamoothy; Russell H Knutsen; Jiali Fang; Robert P Mecham; Yuli Liu; Xiaobo Wu; John P Atkinson; Katherine P Ponder
Journal: Mol Genet Metab Date: 2011-08-24 Impact factor: 4.797

4. Bauhinia bauhinioides cruzipain inhibitor reduces endothelial proliferation and induces an increase of the intracellular Ca2+ concentration.

Authors: Mehmet Bilgin; Christiane Neuhof; Oliver Doerr; Utz Benscheid; Sheila S Andrade; Astrid Most; Yaser Abdallah; Mariana Parahuleva; Dursun Guenduez; Maria L Oliva; Ali Erdogan
Journal: J Physiol Biochem Date: 2010-08-02 Impact factor: 4.158

Review 5. Cathepsin L targeting in cancer treatment.

Authors: Dhivya R Sudhan; Dietmar W Siemann
Journal: Pharmacol Ther Date: 2015-08-20 Impact factor: 12.310

6. Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan. A quantitative comparison of the activities of 95 kDa and 72 kDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinase (PUMP).

Authors: G Murphy; M I Cockett; R V Ward; A J Docherty
Journal: Biochem J Date: 1991-07-01 Impact factor: 3.857