Literature DB >> 35186601

Ipsilateral Hemispheric Brain Atrophy in an Asymptomatic Child With Linear Morphea: A Case Report.

Fahad Albadr1, Hebah A Alnasser2, Reem M Alshathri2.   

Abstract

Scleroderma is a family of systemic and local diseases that tighten and harden the skin and other connective tissues. Local scleroderma (i.e., morphea) typically involves the skin and underlying tissue causing progressive functional and cosmetic disturbances. While the etiology of scleroderma is unknown, it is correlated with autoimmune dysfunction. Linear morphea is a disorder that primarily affects children. This report describes the case of a nine-year-old girl with skin eruptions in the forehead, near the left eye, and in the anterior neck in addition to an underlying focal hemispheric frontal brain atrophy. There is no evidence of neurological deficits in this case. Linear morphea can lead to brain atrophy, causing several neurological dysfunctions such as seizures and cognitive impairment. Follow-up monitoring is critical, and also early recognition of new symptoms for optimal patient outcomes.
Copyright © 2022, Albadr et al.

Entities:  

Keywords:  autoimmune; brain atrophy; linear morphea; localized scleroderma; scleroderma

Year:  2022        PMID: 35186601      PMCID: PMC8850182          DOI: 10.7759/cureus.21344

Source DB:  PubMed          Journal:  Cureus        ISSN: 2168-8184


  10 in total

1.  Linear scleroderma en Coup de Sabre. Relationship with progressive facial hemiatrophy (PFH).

Authors:  M Blaszczyk; S Jablonska
Journal:  Adv Exp Med Biol       Date:  1999       Impact factor: 2.622

Review 2.  Morphea: Current concepts.

Authors:  Stephanie Florez-Pollack; Elaine Kunzler; Heidi T Jacobe
Journal:  Clin Dermatol       Date:  2018-04-10       Impact factor: 3.541

3.  The epidemiology of morphea (localized scleroderma) in Olmsted County 1960-1993.

Authors:  L S Peterson; A M Nelson; W P Su; T Mason; W M O'Fallon; S E Gabriel
Journal:  J Rheumatol       Date:  1997-01       Impact factor: 4.666

Review 4.  Disease course and long-term outcome of juvenile localized scleroderma: Experience from a single pediatric rheumatology Centre and literature review.

Authors:  Giorgia Martini; Gloria Fadanelli; Anna Agazzi; Fabio Vittadello; Alessandra Meneghel; Francesco Zulian
Journal:  Autoimmun Rev       Date:  2018-05-03       Impact factor: 9.754

5.  Linear scleroderma associated with progressive brain atrophy.

Authors:  Salvatore Grosso; Antonella Fioravanti; Giovanni Biasi; Elvira Conversano; Roberto Marcolongo; Guido Morgese; Paolo Balestri
Journal:  Brain Dev       Date:  2003-01       Impact factor: 1.961

6.  Neuroimaging findings in scleroderma en coup de sabre.

Authors:  S Appenzeller; M A Montenegro; S San Juan Dertkigil; P D Sampaio-Barros; J F Marques-Neto; A M Samara; F Andermann; F Cendes
Journal:  Neurology       Date:  2004-05-11       Impact factor: 9.910

7.  A significant proportion of children with morphea en coup de sabre and Parry-Romberg syndrome have neuroimaging findings.

Authors:  Yvonne E Chiu; Sheetal Vora; Eun-Kyung M Kwon; Mohit Maheshwari
Journal:  Pediatr Dermatol       Date:  2012 Nov-Dec       Impact factor: 1.588

Review 8.  Localized scleroderma: clinical spectrum and therapeutic update.

Authors:  Mariana Figueiroa Careta; Ricardo Romiti
Journal:  An Bras Dermatol       Date:  2015 Jan-Feb       Impact factor: 1.896

9.  Neuroimaging and clinical findings in a case of linear scleroderma en coup de sabre.

Authors:  Ikram E Duman; Gazanfer Ekinci
Journal:  Radiol Case Rep       Date:  2018-03-06

Review 10.  Update on Management of Morphea (Localized Scleroderma) in Children.

Authors:  Renu George; Anju George; T Sathish Kumar
Journal:  Indian Dermatol Online J       Date:  2020-03-09
  10 in total

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