| Literature DB >> 3518602 |
A E Frankel, L L Houston, B F Issell, G Fathman.
Abstract
Immunotoxins are formed by chemically linking antibodies to "toxic" polypeptides that inactivate protein synthesis. These hybrid protein molecules are guided to tumor cells by the antibody moiety, and once bound to the tumor cells, the toxic polypeptide moiety penetrates the cell membrane and enzymatically inactivates protein synthesis. A stepwise approach to identifying the potential clinical uses of immunotoxins in cancer therapy is examined in this chapter.Entities:
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Year: 1986 PMID： 3518602 DOI： 10.1146/annurev.me.37.020186.001013
Source DB: PubMed Journal: Annu Rev Med ISSN： 0066-4219 Impact factor: 13.739