| Literature DB >> 3518503 |
C C Campbell, W E Collins, W K Milhous, J M Roberts, A Armstead.
Abstract
The Indochina I/CDC strain of Plasmodium falciparum was linearly passaged in squirrel monkeys (Saimiri sciureus) of 3 phenotypes. Splenectomized monkeys of Guyanan and Peruvian type developed high density parasitemias, but considerably lower than the mean peak parasitemia (greater than 10(6)/mm3) in Bolivian phenotype squirrel monkeys. Spleen-intact Bolivian and Peruvian squirrel monkeys all developed potentially lethal infections after linear passage of parasites from Saimiri and Aotus. For the evaluation of induced immunity to P. falciparum, the Indochina I/CDC strain in Saimiri will be a valuable model system.Entities:
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Year: 1986 PMID： 3518503 DOI： 10.4269/ajtmh.1986.35.472
Source DB: PubMed Journal: Am J Trop Med Hyg ISSN： 0002-9637 Impact factor: 2.345