Literature DB >> 35176140

Bedside to Bench and Back: Identifying a New Clinically Relevant Driver in Pediatric Acute Myeloid Leukemia.

Robert P Hasserjian1, Valentina Nardi1.   

Abstract

In this issue of Blood Cancer Discovery, Umeda and colleagues identify and comprehensively analyze a novel recurrent UBTF mutation (tandem duplications) in pediatric acute myeloid leukemia. Acute myeloid leukemia cases with UBTF tandem duplications display distinctive biologic features, including association with FLT3-ITD and WT1 mutations and high-risk disease, and appear to represent a new genetic subtype of acute myeloid leukemia. See related article by Umeda et al., p. 194 (7). ©2022 American Association for Cancer Research.

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Year:  2022        PMID： 35176140      PMCID： PMC9245378          DOI： 10.1158/2643-3230.BCD-22-0004

Source DB:  PubMed          Journal:  Blood Cancer Discov        ISSN： 2643-3230


  10 in total

1.  Genomic Classification and Prognosis in Acute Myeloid Leukemia.

Authors:  Elli Papaemmanuil; Moritz Gerstung; Hartmut Döhner; Peter J Campbell; Lars Bullinger; Verena I Gaidzik; Peter Paschka; Nicola D Roberts; Nicola E Potter; Michael Heuser; Felicitas Thol; Niccolo Bolli; Gunes Gundem; Peter Van Loo; Inigo Martincorena; Peter Ganly; Laura Mudie; Stuart McLaren; Sarah O'Meara; Keiran Raine; David R Jones; Jon W Teague; Adam P Butler; Mel F Greaves; Arnold Ganser; Konstanze Döhner; Richard F Schlenk
Journal:  N Engl J Med       Date:  2016-06-09       Impact factor: 91.245

2.  Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers.

Authors:  Eric J Duncavage; Molly C Schroeder; Michele O'Laughlin; Roxanne Wilson; Sandra MacMillan; Andrew Bohannon; Scott Kruchowski; John Garza; Feiyu Du; Andrew E O Hughes; Josh Robinson; Emma Hughes; Sharon E Heath; Jack D Baty; Julie Neidich; Matthew J Christopher; Meagan A Jacoby; Geoffrey L Uy; Robert S Fulton; Christopher A Miller; Jacqueline E Payton; Daniel C Link; Matthew J Walter; Peter Westervelt; John F DiPersio; Timothy J Ley; David H Spencer
Journal:  N Engl J Med       Date:  2021-03-11       Impact factor: 91.245

Review 3.  Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel.

Authors:  Hartmut Döhner; Elihu Estey; David Grimwade; Sergio Amadori; Frederick R Appelbaum; Thomas Büchner; Hervé Dombret; Benjamin L Ebert; Pierre Fenaux; Richard A Larson; Ross L Levine; Francesco Lo-Coco; Tomoki Naoe; Dietger Niederwieser; Gert J Ossenkoppele; Miguel Sanz; Jorge Sierra; Martin S Tallman; Hwei-Fang Tien; Andrew H Wei; Bob Löwenberg; Clara D Bloomfield
Journal:  Blood       Date:  2016-11-28       Impact factor: 22.113

4.  Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.

Authors:  Brunangelo Falini; Cristina Mecucci; Enrico Tiacci; Myriam Alcalay; Roberto Rosati; Laura Pasqualucci; Roberta La Starza; Daniela Diverio; Emanuela Colombo; Antonella Santucci; Barbara Bigerna; Roberta Pacini; Alessandra Pucciarini; Arcangelo Liso; Marco Vignetti; Paola Fazi; Natalia Meani; Valentina Pettirossi; Giuseppe Saglio; Franco Mandelli; Francesco Lo-Coco; Pier-Giuseppe Pelicci; Massimo F Martelli
Journal:  N Engl J Med       Date:  2005-01-20       Impact factor: 91.245

5.  Transcriptome analysis offers a comprehensive illustration of the genetic background of pediatric acute myeloid leukemia.

Authors:  Norio Shiba; Kenichi Yoshida; Yusuke Hara; Genki Yamato; Yuichi Shiraishi; Hidemasa Matsuo; Yusuke Okuno; Kenichi Chiba; Hiroko Tanaka; Taeko Kaburagi; Masanobu Takeuchi; Kentaro Ohki; Masashi Sanada; Jun Okubo; Daisuke Tomizawa; Tomohiko Taki; Akira Shimada; Manabu Sotomatsu; Keizo Horibe; Takashi Taga; Souichi Adachi; Akio Tawa; Satoru Miyano; Seishi Ogawa; Yasuhide Hayashi
Journal:  Blood Adv       Date:  2019-10-22

6.  The applicability of the WHO classification in paediatric AML. A NOPHO-AML study.

Authors:  Julie D Sandahl; Eigil Kjeldsen; Jonas Abrahamsson; Shau-Yin Ha; Jesper Heldrup; Kirsi Jahnukainen; Ólafur G Jónsson; Birgitte Lausen; Josefine Palle; Bernward Zeller; Erik Forestier; Henrik Hasle
Journal:  Br J Haematol       Date:  2015-03-29       Impact factor: 6.998

7.  The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions.

Authors:  Hamid Bolouri; Jason E Farrar; Timothy Triche; Rhonda E Ries; Emilia L Lim; Todd A Alonzo; Yussanne Ma; Richard Moore; Andrew J Mungall; Marco A Marra; Jinghui Zhang; Xiaotu Ma; Yu Liu; Yanling Liu; Jaime M Guidry Auvil; Tanja M Davidsen; Patee Gesuwan; Leandro C Hermida; Bodour Salhia; Stephen Capone; Giridharan Ramsingh; Christian Michel Zwaan; Sanne Noort; Stephen R Piccolo; E Anders Kolb; Alan S Gamis; Malcolm A Smith; Daniela S Gerhard; Soheil Meshinchi
Journal:  Nat Med       Date:  2017-12-11       Impact factor: 53.440

8.  Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia.

Authors:  Masayuki Umeda; Jing Ma; Benjamin J Huang; Kohei Hagiwara; Tamara Westover; Sherif Abdelhamed; Juan M Barajas; Melvin E Thomas; Michael P Walsh; Guangchun Song; Liqing Tian; Yanling Liu; Xiaolong Chen; Pandurang Kolekar; Quang Tran; Scott G Foy; Jamie L Maciaszek; Andrew B Kleist; Amanda R Leonti; Bengsheng Ju; John Easton; Huiyun Wu; Virginia Valentine; Marcus B Valentine; Yen-Chun Liu; Rhonda E Ries; Jenny L Smith; Evan Parganas; Ilaria Iacobucci; Ryan Hiltenbrand; Jonathan Miller; Jason R Myers; Evadnie Rampersaud; Delaram Rahbarinia; Michael Rusch; Gang Wu; Hiroto Inaba; Yi-Cheng Wang; Todd A Alonzo; James R Downing; Charles G Mullighan; Stanley Pounds; M Madan Babu; Jinghui Zhang; Jeffrey E Rubnitz; Soheil Meshinchi; Xiaotu Ma; Jeffery M Klco
Journal:  Blood Cancer Discov       Date:  2022-05-05

Review 9.  The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia.

Authors:  Daniel A Arber; Attilio Orazi; Robert Hasserjian; Jürgen Thiele; Michael J Borowitz; Michelle M Le Beau; Clara D Bloomfield; Mario Cazzola; James W Vardiman
Journal:  Blood       Date:  2016-04-11       Impact factor: 22.113

10.  Integrative Genomic Analysis of Pediatric Myeloid-Related Acute Leukemias Identifies Novel Subtypes and Prognostic Indicators.

Authors:  Maarten Fornerod; Jing Ma; Sanne Noort; C Michel Zwaan; Tanja A Gruber; Yu Liu; Michael P Walsh; Lei Shi; Stephanie Nance; Yanling Liu; Yuanyuan Wang; Guangchun Song; Tamara Lamprecht; John Easton; Heather L Mulder; Donald Yergeau; Jacquelyn Myers; Jennifer L Kamens; Esther A Obeng; Martina Pigazzi; Marie Jarosova; Charikleia Kelaidi; Sophia Polychronopoulou; Jatinder K Lamba; Sharyn D Baker; Jeffrey E Rubnitz; Dirk Reinhardt; Marry M van den Heuvel-Eibrink; Franco Locatelli; Henrik Hasle; Jeffery M Klco; James R Downing; Jinghui Zhang; Stanley Pounds
Journal:  Blood Cancer Discov       Date:  2021-09-09
  10 in total
  1 in total

1.  Hyperthermia promotes degradation of the acute promyelocytic leukemia driver oncoprotein ZBTB16/RARα.

Authors:  Qian-Qian Wang; Liaqat Hussain; Pei-Han Yu; Chang Yang; Chen-Ying Zhu; Ya-Fang Ma; Si-Chun Wang; Tao Yang; Yuan-Yuan Kang; Wen-Juan Yu; Yasen Maimaitiyiming; Hua Naranmandura
Journal:  Acta Pharmacol Sin       Date:  2022-10-10       Impact factor: 7.169
  1 in total

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