Association between health behaviours and the COVID-19 vaccination: risk compensation among healthcare workers in Taizhou, China.

This study is conducted to explore the association between health behaviors and the COVID-19 vaccination based on the risk compensation concept among health-care workers in Taizhou, China. We conducted a self-administered online survey to estimate the health behaviors among the staff in a tertiary hospital in Taizhou, China, from May 18 to 21 May 2021. A total of 592 out of 660 subjects (89.7%) responded to the questionnaire after receiving an e-poster on WeChat. Subjects who had been inoculated with the COVID-19 vaccine were asked to mention the differences in their health behaviors before and after the vaccination. The results showed that there were no statistical differences in health behaviors between vaccinated and unvaccinated groups, except in terms of the type of gloves they used (62.8% in the vaccinated group and 49.2% in the unvaccinated group, p = .048). Subjects who received earlier COVID-19 vaccinations exhibited better health behaviors (22.40% increased for duration of wearing masks (P = .007), 25.40% increased for times of washing hands (P = .01), and 20.90% increased for times of wearing gloves (P = .01)). Subjects also revealed better health behaviors (washing hands, wearing gloves, and wearing masks) after vaccination compared to that before. In conclusion, concept of risk compensation was not applied in our findings. The health behaviors did not reduce after the COVID-19 vaccination, which even may improve health behaviors among health-care workers in the hospital setting.

Introduction

The coronavirus disease 2019 (COVID-19) broke out at the end of 2019. Subsequently, the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified as the causative agent by researchers.[1] The virus spread in China and across the world,[1] and, on 11 March 2020, the World Health Organization declared COVID-19 a pandemic. It has caused more than 3.46 million deaths as of 23 May 2021 and extensive damage and destruction to the society and daily life. Regretfully, there are few special antiviral treatments for COVID-19.[2,3]

Vaccines have been proved to be an extremely effective means to deal with epidemics in the past.[4] COVID-19 vaccines have been producing at an amazing rate globally in an effort to deal with the pandemic.[2] Countries around the world are at full steam, accelerating research and development of COVID-19 vaccines; there have been over 160 vaccine candidates to date, with approximately 20 in clinical evaluation.[2] In China, at least five different COVID-19 vaccines across three platforms have been conditionally approved for emergency use.[5] A global survey revealed that 54.85–88.62% of respondents were willing to accept the COVID-19 vaccine.[6]

Health behaviors, such as washing hands and wearing face masks and gloves, are of great importance in combating COVID-19. Wearing face masks in public is one of the key measures to control the spread of COVID-19.[7] The use of face masks has also been associated with a reduction in the risk of COVID-19 infection.[7] Healthcare workers are encouraged by the WHO to wear gloves when engaged in the direct care of patients and even to wear double gloves when dealing with COVID-19 patients’ airways, urine, blood, and other body fluids, for as long as the pandemic continues.[8] Touching contaminated surfaces followed by a hand-to-face transfer has been confirmed as a potential infection route.[9] Because humans involuntarily touch their faces more than 20 times per hour, thus washing hands with soap and water is recommended to prevent this transmission.[9]

Risk compensation – which occurs when people adjust their behaviors based on diminished perceived susceptibility resulting from participation in some preventive intervention – creates a subsequent increase in risk behaviors.[10,11] Some direct associations between risk compensation and vaccines exist. For example, a decrease in condom use after Human immunodeficiency virus (HIV) vaccination[12] and an increase in risky sexual behaviors after human papillomavirus (HPV) vaccinations have been reported.[13] The risk compensation theory suggests that healthcare workers may engage in fewer health behaviors after receiving the COVID-19 vaccination, however, this is supported by empirical evidence. Therefore, we conducted a questionnaire survey to address this topic and assess the situation among healthcare workers in China.

Materials and methods

Study design and population

We conducted an anonymous cross-sectional survey online via the WeChat-incorporated Wen-Juan – Xing platform (Changsha Ranxing information Technology Co., Ltd., Hunan, China), the largest online survey platform in China, and provided freely to all customers.[5] The medical staff who worked in tertiary hospital in Taizhou, China, were our target population. As shown Figure 1, a total of 1,173 healthy professionals (doctors, nurses, pharmacists and medical technicians) and administrative support staff (janitors, nursing aides and dietary aides) were notified to report their health behaviors via WeChat. Additionally, 660 interviewees volunteered to answer the self-administered questionnaire between 18 and 21 May 2021. The response rate was 56.3%. Of these volunteers, 68 were excluded because of inadequate time (less than 180 seconds) to complete the questionnaire. Finally, 592 questionnaires with valid data were included in this study (response rate: 89.7%, 592/660). We investigated the subjects gender, knowledge, category of employment, and health behaviors such as wearing masks, wearing gloves, and washing hands. Their experiences with negative emotions (anxiety, panic, and fear) of were also noted. Subjects who had been inoculated with the COVID-19 vaccine were asked to mention the differences in their health behaviors before and after the vaccination. This survey was exempted from informed consent and approved by the Ethics Committee of Enze Hospital of Zhejiang province (approval number:K20210501) in China. Participants was anonymized. The COVID-19 vaccine in this study was inactive and manufactured by Sinovac.The Chinese government provided the COVID-19 vaccine freely to healthcare workers.

Figure 1.

Flowchat of sample size determination method.

Questionnaires

We consulted experts at the infection-control department in the study hospital regarding the protective health behaviors of the hospital staff during the COVID-19 pandemic in order to create and conduct a self-administered questionnaire. The questionnaire comprised the following items related to:

Basic demographic information including gender, education, and professional/technical title

Health behaviors followed as a result of the COVID-19 pandemic, as assessed by the questions: ‘What is the situation about wearing masks, gloves and washing hands?’

COVID-19 vaccination status, as assessed by the questions: ‘Did you get the COVID-19 vaccination?’ and ‘If you did, when did you get it? ‘

Comparison of health behaviors among vaccinated protections before and after receiving the COVID-19 vaccination in terms of wearing masks, wearing gloves and washing hands

Experience of negative emotions (anxiety, panic and fear) as a result of the prevalence of COVID-19.

Statistical analysis

All data were analyzed using IBM SPSS statistics 22.0 software (SPSS Inc., Chicago, IL, USA).In the univariate analysis, the χ2-test was used to assess categorical variables between subjects with and without fatigue. The primary outcome of this survey was the adherence to health behaviors following the outbreak of COVID-19 pandemic and the difference of health behaviors among vaccinated protections before and after the vaccination. All respondents provided answers the regard to the health behaviors they followed and almost answered whether they had received the vaccine. Follow-up questions, such as the time of receiving the first dose of the vaccine were answered by responders the vaccinated participants. A p-value of <0.05 was considered to represent a statistically significant difference among the test population.

Results

Characteristics of the study population

A total of 592 hospital staff completed the questionnaire. The sample comprised 87 men (14.7%) and 505 women (85.3). All of them reported their health behaviors and negative emotions after the outbreak of COVID-19. Among all the staff, 522 (88.2%) received at least one dose of the COVID-19 vaccine, 59 were unvaccinated, and 11 participants did not report whether they had received the COVID-19 vaccine for unknown reasons. Excluding these 11 participants, the demographic variables of the remaining participants’ education level, professional title, position, and years of service are described in Table 1.

Table 1.

Baseline characteristics of subjects

	Variables	All (%)(n = 581)	Vaccination (%) (n = 522)	Unvaccination (%)(n = 59)	χ2 or T	P
Sex	Men	84(14.5)	81(15.5)	3(5.1)	4.665	0.031
	Women	497(85.5)	441(84.5)	56(94.1)
Age		31.8 ± 8.2	31.8 ± 8.2	31.5 ± 9.0	0.234	0.815
Education	Junior college and below	177(30.5)	157(30.1)	20(33.9)	0.365	0.545
	Undergraduate and above	404(69.5)	365(69.9)	39(66.1)
Position					1.238	0.538
	Doctor	131(22.5)	116(22.2)	15(25.4)
	Nurse	412(70.9)	370(70.9)	42(71.2)
	Administration and support crew	38(6.5)	36(6.9)	2(3.4)
Professional titles					23.18	<0.001
	Internship	59(10.2)	43(8.2)	16(27.1)
	Primary grade	282(48.5)	264(50.6)	18(30.5)
	Medium grade	145(25.0)	129(24.7)	16(27.1)
	High grade and others	95(16.4)	86(16.5)	9(15.3)

Behaviors of healthcare workers during the COVID-19 pandemic

In our survey, we investigated the different health behaviors of vaccinated and unvaccinated respondents. Table 2 indicates that the type of gloves used was associated with being vaccinated, although other health behaviors showed no association.

Table 2.

Behaviors of healthcare workers during the COVID-19 pandemic

Variables	All (%)(n = 581)	Vaccinated (%) (n = 522)	Unvaccinated (%)(n = 59)	χ2	P
Always wearing masks while working				0.01	0.922
Yes	560(96.4)	503(96.4)	57(96.6)
No	21(3.6)	19(3.6)	2(3.4)
Type of masks
N95/Surgical masks	558(96.0)	503(96.4)	55(93.2)	1.37	0.241
Normal masks	23(4.0)	19(3.6)	4(6.8)
Time of changing masks				0.43	0.809
<6 h	414(71.3)	370(70.9)	44(74.6)
6 h ~ 12 h	138(23.8)	126(24.1)	12(20.3)
>12 h	29(5.0)	26(5.0)	3(5.1)
Squeezing the tip of mask when wearing masks
No	256(44.1)	231(44.3)	25(42.4)	2.75	0.431
Yes	325(55.9)	291(55.7)	34(57.6)
Masking nose and mouth
No	156(26.9)	144(27.6)	12(20.3)	1.42	0.234
Yes	425(73.1)	378(72.4)	47(79.7)
Washing hands after taking off masks
No	163(28.1)	149(28.5)	14(23.7)	0.61	0.435
Yes	418(71.9)	373(71.5)	45(76.3)
Always follow the Seven Steps method of washing hands
Yes	409(70.4)	364(69.7)	45(76.3)	1.09	0.297
No	172(29.6)	158(30.3)	14(23.7)
Always spend over 15 seconds every step of the Seven Steps method of washing hands
Yes	380(65.4)	340(65.1)	40(67.8)	0.17	0.684
No	201(34.6)	182(34.9)	19(32.2)
Always wear gloves before performing medical operations
Yes	278(47.8)	255(48.9)	23(39.0)	2.07	0.150
No	303(52.2)	267(51.1)	36(61.0)
Type of gloves
Disposable sterile surgical gloves	74(12.7)	67(12.8)	7(11.9)	6.06	0.048
Disposable rubber gloves	357(61.4)	328(62.8)	29(49.2)
Disposable film gloves	150(25.8)	127(24.3)	23(39.0)
Whether hands are washed in the follow situation
Before contact with patient	542(93.3)	488(93.5)	54(91.5)	/	0.580
Before aseptic operation	562(96.7)	504(96.6)	58(98.3)	/	0.709
After contact with patient	567(97.6)	509(97.5)	58(98.3)	/	1.000
After touching objects around the patients	550(94.7)	496(95.0)	54(91.5)	/	0.230
After touching body fluid of the patients	566(97.4)	508(97.3)	58(98.3)	/	1.000

Differences in health behaviors among vaccinated healthcare workers

As shown in Figure 2, based on time of the first vaccination, the increase in the duration of wearing masks, frequency of washing hands, and frequency of wearing gloves after vaccination was significantly different. By comparing health behaviors in pre- and post-vaccination, we found an obvious increase in the duration of wearing masks, frequency of washing hands, and frequency of wearing gloves among our sample (Figure 3).

Figure 2.

Association between time of first vaccination and increased health behaviors.

Figure 3.

Increased health behaviors post-inoculation compared to pre-inoculation among recipients of the COVID-19 vaccine.

Experience of negative emotions (anxiety, panic, and fear) during COVID-19

Our survey data indicate that 61.15% of the participants never experienced negative emotions, while there was a reduction in the negative emotions among only 6.52% of the participants after the COVID-19 vaccination. These results are described in Table 3.

Table 3.

Experience of negative emotions (anxiety, panic, and fear) during working hours related with COVID-19 prevalence and vaccine inoculation

Experience of negative emotions during working hours and COVID-19 prevalence
	All (n = 592) %
Always	4(0.68)
Usually	13(2.2)
Seldom	213(35.98)
Never	362(61.15)
Experience of negative emotions post-inoculation compared to pre-inoculation among recipients of the COVID-19 vaccine during working hours.
	All (n = 230) %
Increased	15 (6.52)
Equally	121 (52.61)
Decreased	94(40.87)

Discussion

Clinical implications

To our knowledge, this is the first study to investigate the relationship between COVID-19 vaccine and health behaviors. Our study may provide population-based empirical data on this relationship.

Risk compensation, in which individuals respond to safety measures with a compensatory increase in risky behaviors, is named the “Peltzman Effect” after University of Chicago economist Sam Peltzman who first described it in 1975.[14] A comprehensive review of the Peltzman Effect identified four main factors – visibility, motivation, control, and effectiveness – as likely contributors to risk compensation, all of which appear to be present in the COVID-19 pandemic.[14] Four interventions are believed to lead to risk compensation – wearing of bike or ski helmets (purportedly leading to riskier cycling or skiing), circumcision to prevent HIV infection, HIV pre-exposure prophylaxis, and HPV vaccination (all purportedly leading to increased unprotected sexual activity).[15] One of the most alarming features of the Peltzman Effect is that there may exist a bystander component, which suggests that, even those who have not received the COVID-19 vaccine may stop wearing masks and social distancing if they aware that others have received the vaccine.[14]

Preventive HIV vaccines have the potential to curtail the HIV epidemic. As the first HIV vaccines on the market may only be effective to a limited extent, risk compensation could severely weaken and even offset the vaccine’s public health benefit.[11] In fact, some studies have reported that a combination of frequent risk compensation and low vaccine effectiveness by an HIV vaccine campaign could actually increase the incidence of HIV.[11] In addition, risk compensation has been employed in a sensationalistic manner to stop HIV vaccine development, similar to the misleading arguments leveled against the introduction of other preventive and safety interventions that have since rescued millions of lives, ranging from seatbelt regulations and speed limits to condoms.[16] Some parents worry that their children may be more likely to engage in sex, or experience unprotected sex, if inoculated against the sexually transmitted HPV, which could cause cervical cancer.[17] This worry could be one of the reasons why the efficacious HPV vaccine has a lower uptake compared to many other vaccines, and despite being provided free of charge in organized childhood vaccination programmes.[17]

No evidence for an increase in any outcome deemed to reflect risk compensation has been provided by the most recent systematic reviews for any intervention.[15] In studies, when participants are asked about their personal likelihood of risk compensation, they anticipate fewer behavioral change.[11] Risk compensation exerted no prominent impact on young women in terms of engaging in sexual activity or refraining from using condoms after being inoculation with HPV vaccine.[18] Moreover, no association was discovered between the HPV vaccination and risky sexual behaviors.[19]

We summarized the relationship between risk compensation and vaccines in different populations, as presented in Table 4. Not all the results indicated that the average tendency was to agree with the risk compensation statements. This study revealed that healthcare workers do not necessarily engage in fewer non-pharmacological interventions, such as washing hands, wearing masks, and wearing gloves, after receiving the COVID-19 vaccination. More importantly, our study indicates that healthcare workers who had been vaccinated early enhanced and practiced better after the inoculation. However, we still do not understand whether actual risk compensation behaviors will occur following COVID-19 vaccination in terms of reduced disease prevention efforts. This needs to be further considered in less hypothetical studies as more and more people get vaccinated.

Table 4.

Determing whether a relationship exists between risk compensation and vaccine in different studies

Author (year)	Study design	Study period	Screened number	Setting	Relationship	Reference
Terence Wua et al(2019)	Cross-sectional study	July to December 2017	624	Hong Kong	No	[20]
Julia E. Painter et al(2017)	Cross-sectional study	2011–2013	505	Atlanta	No	[21]
Laura A.V. Marlow et al(2009)	Cross-sectional study	November 2006 to	332(study 1)	England, Scotland,
		February 2007(study 1)		and Wales(study 1)	Yes	[13]
		April to	360(study 2)	Southeast
		July 2007(study 2)		England(study 2)
Peter A. Newmana et al(2010)	Cross-sectional study	March 2008 to February 2009	255	Bangkok and Chiang Mai	Yes	[16]
Peter A. Newman et al (2009)	Cross-sectional study	August 2006 to May 2007	1164	Los Angeles	Yes	[12]
Noel T. Brewer et al(2007)	Cross-sectional study	Spring 1999 to fall 2000	745	Northeastern United States	Yes	[22]
Julia E. Painter(2017)	Cross-sectional study	Unknown	321	Atlanta, Georgia	Yes	[23]
Andrew J. Leidner(2020)	Cross-sectional study	2007 to 2014	12370	US	No	[24]
Nicole C. Liddon (2012)	Cross-sectional study	2007–2008	1243	US	No	[14]
Gustavo Saraiva Frio (2021)	Cross-sectional study	2015	35420	Brazil	No	[11]

Methodological considerations

Our survey comprises some limitations. First, accurate information cannot be guaranteed by self-administrated online questionnaires. However, we conducted a logic data check and called back to revise any non-logical data. Second, affected by the current prevalence of the COVID-19, the implementation of non-pharmacological interventions may be overestimated. The respondents were asked to recall their behaviors prior to COVID-19, which may have resulted in inaccurate information. A low response rate in this study is another drawback. However, we still had sufficient statistical power to evaluate the health behaviors before and after vaccination (power = 85%, α = 0.05). In addition, the survey respondents were likely to be younger and healthier than the general population, which could have resulted in selection bias.

Conclusions

In conclusion, concept of the risk compensation was not applied in our findings. The health behaviors did not reduce after the COVID-19 vaccination, which even may improve health behaviors among healthcare workers in the hospital setting. Further large-scale population-based investigations are needed to identify the application of risk compensation theory for the association between health behaviors and the COVID-19 vaccination.