Literature DB >> 35175472

The Effect of Polymorphisms of Energy Metabolism Genes on Metabolic Disorders in Overweight Adolescents of Two Ethnicities.

K D Ievleva1, T A Bairova2, E A Sheneman2, Zh G Ayurova2, V V Balzhieva2, E A Novikova2, O V Bugun2, S I Kolesnikov2, L V Rychkova2, L I Kolesnikova2.   

Abstract

The aim of this cross-sectional observational study is to determine the contribution of polymorphisms of energy metabolism genes into metabolic disorders in Russian and Buryat adolescents with overweight and obesity. The study included 354 Russian and Buryat adolescents aged 13-18 years. Body mass index and serum levels of glucose, insulin, and leptin were measured and insulin resistance index HOMA-IR was calculated. Molecular genetic analysis for the presence of 9 loci of energy metabolism genes LEP, LEPR, POMC, FTO, and MC4R were analyzed. It was found that the risk of metabolic disorders is associated with the presence of polymorphic loci of leptin receptor gene LEPR and melanocortin receptor gene MC4R (LEPR rs1137100+LEPR rs1137101 and LEPR rs1137100+MC4R rs17782313) in Russian adolescents with overweight and obesity and polymorphisms of the gene FTO (FTO rs9939609+rs8050136) associated with fat mass and obesity in Buryat adolescents.
© 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  FTO; LEPR; MC4R; adolescents; overweight

Mesh：

Substances：

Year:  2022        PMID： 35175472     DOI： 10.1007/s10517-022-05408-3

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  10 in total

Review 1.  Evidences on three relevant obesogenes: MC4R, FTO and PPARγ. Approaches for personalized nutrition.

Authors:  Cristina Razquin; Amelia Marti; Jose Alfredo Martinez
Journal:  Mol Nutr Food Res       Date:  2010-12-01       Impact factor: 5.914

2.  Anthropometric and Metabolic Responses in FTO rs9939609 Gene Polymorphism after a Multidisciplinary Lifestyle Intervention in Overweight and Obese Adolescents.

Authors:  Cláudia Daniela Barbian; Cézane Priscila Reuter; Jane Dagmar Pollo Renner; Priscila Tatiana da Silva; Elisa Inês Klinger; James Philip Hobkirk; Andréia Rosane de Moura Valim; Miria Suzana Burgos
Journal:  J Pediatr Genet       Date:  2019-11-07

3.  Evaluation of MC4R [rs17782313, rs17700633], AGRP [rs3412352] and POMC [rs1042571] Polymorphisms with Obesity in Northern India.

Authors:  Apurva Srivastava; Balraj Mittal; Jai Prakash; Varun Shanker Narain; S M Natu; Neena Srivastava
Journal:  Oman Med J       Date:  2014-03

Review 4.  Leptin in human physiology and pathophysiology.

Authors:  Christos S Mantzoros; Faidon Magkos; Mary Brinkoetter; Elizabeth Sienkiewicz; Tina A Dardeno; Sang-Yong Kim; Ole-Petter R Hamnvik; Anastasia Koniaris
Journal:  Am J Physiol Endocrinol Metab       Date:  2011-07-26       Impact factor: 4.310

5.  Childhood obesity: are genetic differences involved?

Authors:  Claude Bouchard
Journal:  Am J Clin Nutr       Date:  2009-03-04       Impact factor: 7.045

Review 6.  Obesity genetics and cardiometabolic health: Potential for risk prediction.

Authors:  Dharambir K Sanghera; Cynthia Bejar; Sonali Sharma; Rajeev Gupta; Piers R Blackett
Journal:  Diabetes Obes Metab       Date:  2019-03-20       Impact factor: 6.577

7.  Genetic studies of body mass index yield new insights for obesity biology.

Authors:  Adam E Locke; Bratati Kahali; Sonja I Berndt; Anne E Justice; Tune H Pers; Felix R Day; Corey Powell; Sailaja Vedantam; Martin L Buchkovich; Jian Yang; Damien C Croteau-Chonka; Tonu Esko; Tove Fall; Teresa Ferreira; Stefan Gustafsson; Zoltán Kutalik; Jian'an Luan; Reedik Mägi; Joshua C Randall; Thomas W Winkler; Andrew R Wood; Tsegaselassie Workalemahu; Jessica D Faul; Jennifer A Smith; Jing Hua Zhao; Wei Zhao; Jin Chen; Rudolf Fehrmann; Åsa K Hedman; Juha Karjalainen; Ellen M Schmidt; Devin Absher; Najaf Amin; Denise Anderson; Marian Beekman; Jennifer L Bolton; Jennifer L Bragg-Gresham; Steven Buyske; Ayse Demirkan; Guohong Deng; Georg B Ehret; Bjarke Feenstra; Mary F Feitosa; Krista Fischer; Anuj Goel; Jian Gong; Anne U Jackson; Stavroula Kanoni; Marcus E Kleber; Kati Kristiansson; Unhee Lim; Vaneet Lotay; Massimo Mangino; Irene Mateo Leach; Carolina Medina-Gomez; Sarah E Medland; Michael A Nalls; Cameron D Palmer; Dorota Pasko; Sonali Pechlivanis; Marjolein J Peters; Inga Prokopenko; Dmitry Shungin; Alena Stančáková; Rona J Strawbridge; Yun Ju Sung; Toshiko Tanaka; Alexander Teumer; Stella Trompet; Sander W van der Laan; Jessica van Setten; Jana V Van Vliet-Ostaptchouk; Zhaoming Wang; Loïc Yengo; Weihua Zhang; Aaron Isaacs; Eva Albrecht; Johan Ärnlöv; Gillian M Arscott; Antony P Attwood; Stefania Bandinelli; Amy Barrett; Isabelita N Bas; Claire Bellis; Amanda J Bennett; Christian Berne; Roza Blagieva; Matthias Blüher; Stefan Böhringer; Lori L Bonnycastle; Yvonne Böttcher; Heather A Boyd; Marcel Bruinenberg; Ida H Caspersen; Yii-Der Ida Chen; Robert Clarke; E Warwick Daw; Anton J M de Craen; Graciela Delgado; Maria Dimitriou; Alex S F Doney; Niina Eklund; Karol Estrada; Elodie Eury; Lasse Folkersen; Ross M Fraser; Melissa E Garcia; Frank Geller; Vilmantas Giedraitis; Bruna Gigante; Alan S Go; Alain Golay; Alison H Goodall; Scott D Gordon; Mathias Gorski; Hans-Jörgen Grabe; Harald Grallert; Tanja B Grammer; Jürgen Gräßler; Henrik Grönberg; Christopher J Groves; Gaëlle Gusto; Jeffrey Haessler; Per Hall; Toomas Haller; Goran Hallmans; Catharina A Hartman; Maija Hassinen; Caroline Hayward; Nancy L Heard-Costa; Quinta Helmer; Christian Hengstenberg; Oddgeir Holmen; Jouke-Jan Hottenga; Alan L James; Janina M Jeff; Åsa Johansson; Jennifer Jolley; Thorhildur Juliusdottir; Leena Kinnunen; Wolfgang Koenig; Markku Koskenvuo; Wolfgang Kratzer; Jaana Laitinen; Claudia Lamina; Karin Leander; Nanette R Lee; Peter Lichtner; Lars Lind; Jaana Lindström; Ken Sin Lo; Stéphane Lobbens; Roberto Lorbeer; Yingchang Lu; François Mach; Patrik K E Magnusson; Anubha Mahajan; Wendy L McArdle; Stela McLachlan; Cristina Menni; Sigrun Merger; Evelin Mihailov; Lili Milani; Alireza Moayyeri; Keri L Monda; Mario A Morken; Antonella Mulas; Gabriele Müller; Martina Müller-Nurasyid; Arthur W Musk; Ramaiah Nagaraja; Markus M Nöthen; Ilja M Nolte; Stefan Pilz; Nigel W Rayner; Frida Renstrom; Rainer Rettig; Janina S Ried; Stephan Ripke; Neil R Robertson; Lynda M Rose; Serena Sanna; Hubert Scharnagl; Salome Scholtens; Fredrick R Schumacher; William R Scott; Thomas Seufferlein; Jianxin Shi; Albert Vernon Smith; Joanna Smolonska; Alice V Stanton; Valgerdur Steinthorsdottir; Kathleen Stirrups; Heather M Stringham; Johan Sundström; Morris A Swertz; Amy J Swift; Ann-Christine Syvänen; Sian-Tsung Tan; Bamidele O Tayo; Barbara Thorand; Gudmar Thorleifsson; Jonathan P Tyrer; Hae-Won Uh; Liesbeth Vandenput; Frank C Verhulst; Sita H Vermeulen; Niek Verweij; Judith M Vonk; Lindsay L Waite; Helen R Warren; Dawn Waterworth; Michael N Weedon; Lynne R Wilkens; Christina Willenborg; Tom Wilsgaard; Mary K Wojczynski; Andrew Wong; Alan F Wright; Qunyuan Zhang; Eoin P Brennan; Murim Choi; Zari Dastani; Alexander W Drong; Per Eriksson; Anders Franco-Cereceda; Jesper R Gådin; Ali G Gharavi; Michael E Goddard; Robert E Handsaker; Jinyan Huang; Fredrik Karpe; Sekar Kathiresan; Sarah Keildson; Krzysztof Kiryluk; Michiaki Kubo; Jong-Young Lee; Liming Liang; Richard P Lifton; Baoshan Ma; Steven A McCarroll; Amy J McKnight; Josine L Min; Miriam F Moffatt; Grant W Montgomery; Joanne M Murabito; George Nicholson; Dale R Nyholt; Yukinori Okada; John R B Perry; Rajkumar Dorajoo; Eva Reinmaa; Rany M Salem; Niina Sandholm; Robert A Scott; Lisette Stolk; Atsushi Takahashi; Toshihiro Tanaka; Ferdinand M van 't Hooft; Anna A E Vinkhuyzen; Harm-Jan Westra; Wei Zheng; Krina T Zondervan; Andrew C Heath; Dominique Arveiler; Stephan J L Bakker; John Beilby; Richard N Bergman; John Blangero; Pascal Bovet; Harry Campbell; Mark J Caulfield; Giancarlo Cesana; Aravinda Chakravarti; Daniel I Chasman; Peter S Chines; Francis S Collins; Dana C Crawford; L Adrienne Cupples; Daniele Cusi; John Danesh; Ulf de Faire; Hester M den Ruijter; Anna F Dominiczak; Raimund Erbel; Jeanette Erdmann; Johan G Eriksson; Martin Farrall; Stephan B Felix; Ele Ferrannini; Jean Ferrières; Ian Ford; Nita G Forouhi; Terrence Forrester; Oscar H Franco; Ron T Gansevoort; Pablo V Gejman; Christian Gieger; Omri Gottesman; Vilmundur Gudnason; Ulf Gyllensten; Alistair S Hall; Tamara B Harris; Andrew T Hattersley; Andrew A Hicks; Lucia A Hindorff; Aroon D Hingorani; Albert Hofman; Georg Homuth; G Kees Hovingh; Steve E Humphries; Steven C Hunt; Elina Hyppönen; Thomas Illig; Kevin B Jacobs; Marjo-Riitta Jarvelin; Karl-Heinz Jöckel; Berit Johansen; Pekka Jousilahti; J Wouter Jukema; Antti M Jula; Jaakko Kaprio; John J P Kastelein; Sirkka M Keinanen-Kiukaanniemi; Lambertus A Kiemeney; Paul Knekt; Jaspal S Kooner; Charles Kooperberg; Peter Kovacs; Aldi T Kraja; Meena Kumari; Johanna Kuusisto; Timo A Lakka; Claudia Langenberg; Loic Le Marchand; Terho Lehtimäki; Valeriya Lyssenko; Satu Männistö; André Marette; Tara C Matise; Colin A McKenzie; Barbara McKnight; Frans L Moll; Andrew D Morris; Andrew P Morris; Jeffrey C Murray; Mari Nelis; Claes Ohlsson; Albertine J Oldehinkel; Ken K Ong; Pamela A F Madden; Gerard Pasterkamp; John F Peden; Annette Peters; Dirkje S Postma; Peter P Pramstaller; Jackie F Price; Lu Qi; Olli T Raitakari; Tuomo Rankinen; D C Rao; Treva K Rice; Paul M Ridker; John D Rioux; Marylyn D Ritchie; Igor Rudan; Veikko Salomaa; Nilesh J Samani; Jouko Saramies; Mark A Sarzynski; Heribert Schunkert; Peter E H Schwarz; Peter Sever; Alan R Shuldiner; Juha Sinisalo; Ronald P Stolk; Konstantin Strauch; Anke Tönjes; David-Alexandre Trégouët; Angelo Tremblay; Elena Tremoli; Jarmo Virtamo; Marie-Claude Vohl; Uwe Völker; Gérard Waeber; Gonneke Willemsen; Jacqueline C Witteman; M Carola Zillikens; Linda S Adair; Philippe Amouyel; Folkert W Asselbergs; Themistocles L Assimes; Murielle Bochud; Bernhard O Boehm; Eric Boerwinkle; Stefan R Bornstein; Erwin P Bottinger; Claude Bouchard; Stéphane Cauchi; John C Chambers; Stephen J Chanock; Richard S Cooper; Paul I W de Bakker; George Dedoussis; Luigi Ferrucci; Paul W Franks; Philippe Froguel; Leif C Groop; Christopher A Haiman; Anders Hamsten; Jennie Hui; David J Hunter; Kristian Hveem; Robert C Kaplan; Mika Kivimaki; Diana Kuh; Markku Laakso; Yongmei Liu; Nicholas G Martin; Winfried März; Mads Melbye; Andres Metspalu; Susanne Moebus; Patricia B Munroe; Inger Njølstad; Ben A Oostra; Colin N A Palmer; Nancy L Pedersen; Markus Perola; Louis Pérusse; Ulrike Peters; Chris Power; Thomas Quertermous; Rainer Rauramaa; Fernando Rivadeneira; Timo E Saaristo; Danish Saleheen; Naveed Sattar; Eric E Schadt; David Schlessinger; P Eline Slagboom; Harold Snieder; Tim D Spector; Unnur Thorsteinsdottir; Michael Stumvoll; Jaakko Tuomilehto; André G Uitterlinden; Matti Uusitupa; Pim van der Harst; Mark Walker; Henri Wallaschofski; Nicholas J Wareham; Hugh Watkins; David R Weir; H-Erich Wichmann; James F Wilson; Pieter Zanen; Ingrid B Borecki; Panos Deloukas; Caroline S Fox; Iris M Heid; Jeffrey R O'Connell; David P Strachan; Kari Stefansson; Cornelia M van Duijn; Gonçalo R Abecasis; Lude Franke; Timothy M Frayling; Mark I McCarthy; Peter M Visscher; André Scherag; Cristen J Willer; Michael Boehnke; Karen L Mohlke; Cecilia M Lindgren; Jacques S Beckmann; Inês Barroso; Kari E North; Erik Ingelsson; Joel N Hirschhorn; Ruth J F Loos; Elizabeth K Speliotes
Journal:  Nature       Date:  2015-02-12       Impact factor: 49.962

Review 8.  Genetics of obesity.

Authors:  Stephen O'Rahilly; I Sadaf Farooqi
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2006-07-29       Impact factor: 6.237

9.  Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach.

Authors:  Michael M Mendelson; Riccardo E Marioni; Roby Joehanes; Chunyu Liu; Åsa K Hedman; Stella Aslibekyan; Ellen W Demerath; Weihua Guan; Degui Zhi; Chen Yao; Tianxiao Huan; Christine Willinger; Brian Chen; Paul Courchesne; Michael Multhaup; Marguerite R Irvin; Ariella Cohain; Eric E Schadt; Megan L Grove; Jan Bressler; Kari North; Johan Sundström; Stefan Gustafsson; Sonia Shah; Allan F McRae; Sarah E Harris; Jude Gibson; Paul Redmond; Janie Corley; Lee Murphy; John M Starr; Erica Kleinbrink; Leonard Lipovich; Peter M Visscher; Naomi R Wray; Ronald M Krauss; Daniele Fallin; Andrew Feinberg; Devin M Absher; Myriam Fornage; James S Pankow; Lars Lind; Caroline Fox; Erik Ingelsson; Donna K Arnett; Eric Boerwinkle; Liming Liang; Daniel Levy; Ian J Deary
Journal:  PLoS Med       Date:  2017-01-17       Impact factor: 11.069

10.  Association between LEPR, FTO, MC4R, and PPARG-2 polymorphisms with obesity traits and metabolic phenotypes in school-aged children.

Authors:  Sílvia M Almeida; José M Furtado; Paulo Mascarenhas; Maria E Ferraz; José C Ferreira; Mariana P Monteiro; Manuel Vilanova; Fernando P Ferraz
Journal:  Endocrine       Date:  2018-04-20       Impact factor: 3.633
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.