| Literature DB >> 35175466 |
P V Panteleev1, I A Bolosov1, V A Khokhlova1, G Dhanda2, S V Balandin1, J Haldar2, T V Ovchinnikova3.
Abstract
Recombinant analogs of a number of natural host-defense mammalian cathelicidins were obtained and predominant mechanism of their antibacterial action was studied. The ability of cathelicidins to suppress the growth of Pseudomonas aeruginosa producing metallo-β-lactamases (MβL) was studied, and the possibility of appearance of cathelicidin-resistant bacteria was evaluated. Among peptides with different structures and mechanisms of action, only the strains resistant to ChMAP-28 were not obtained, which indicated minimum risk of the development of natural resistance to this cathelicidin. High antibacterial activity, wide spectrum of action, and the absence of cross-resistance effects allow considering ChMAP-28 peptide as a candidate to be developed further as a therapeutic agent against MβL-producing bacteria.Entities:
Keywords: antimicrobial peptides; cathelicidins; gram-negative bacteria; metallo-β-lactamases (MβL); resistance
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Year: 2022 PMID： 35175466 DOI： 10.1007/s10517-022-05411-8
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804