Achim Lother1,2, Frédéric Jaisser3,4, Ulrich O Wenzel5. 1. Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany. 2. Department of Cardiology and Angiology I, University Heart Center, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. 3. Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France. 4. INSERM, Clinical Investigation Centre 1433, French-Clinical Research Infrastructure Network (F-CRIN) INI-CRCT, Nancy, France. 5. III. Medizinische Klinik, University Hospital Hamburg-Eppendorf, Hamburg, Germany.