OBJECTIVE: To explore the value of arterial enhancement fraction (AEF) of CT perfusion in evaluating the postoperative treatment efficacy on liver cancer (LC). METHODS: Clinical data of 60 patients with LC who were treated with transcatheter arterial chemoembolization for LC in our hospital from Jan. 2015 to Jan. 2017 were analyzed retrospectively. They underwent CT scanning before and after surgery. The change of arterial enhancement fraction (AEF) was analyzed, and its value in efficacy evaluation was assessed. RESULTS: After surgery, the AEF value of the effective group decreased greatly (P<0.05) and was significantly lower than that of the ineffective group (P<0.05). Alpha fetal protein (AFP) of both groups decreased after surgery, with a significantly lower AFP level in the effective group than that in the ineffective group (P<0.05). AEF and AFP were positively correlated. According to the follow-up results, patients with a low AEF level showed a higher survival rate than those with a high level. Cox regression analysis revealed that AEF was an independent factor for patients' prognosis. CONCLUSION: CT perfusion imaging parameters are of high clinical value for patients with primary LC after therapy and can be used as independent factors for their prognosis. AJTR
OBJECTIVE: To explore the value of arterial enhancement fraction (AEF) of CT perfusion in evaluating the postoperative treatment efficacy on liver cancer (LC). METHODS: Clinical data of 60 patients with LC who were treated with transcatheter arterial chemoembolization for LC in our hospital from Jan. 2015 to Jan. 2017 were analyzed retrospectively. They underwent CT scanning before and after surgery. The change of arterial enhancement fraction (AEF) was analyzed, and its value in efficacy evaluation was assessed. RESULTS: After surgery, the AEF value of the effective group decreased greatly (P<0.05) and was significantly lower than that of the ineffective group (P<0.05). Alpha fetal protein (AFP) of both groups decreased after surgery, with a significantly lower AFP level in the effective group than that in the ineffective group (P<0.05). AEF and AFP were positively correlated. According to the follow-up results, patients with a low AEF level showed a higher survival rate than those with a high level. Cox regression analysis revealed that AEF was an independent factor for patients' prognosis. CONCLUSION: CT perfusion imaging parameters are of high clinical value for patients with primary LC after therapy and can be used as independent factors for their prognosis. AJTR
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Authors: Tomi Akinyemiju; Semaw Abera; Muktar Ahmed; Noore Alam; Mulubirhan Assefa Alemayohu; Christine Allen; Rajaa Al-Raddadi; Nelson Alvis-Guzman; Yaw Amoako; Al Artaman; Tadesse Awoke Ayele; Aleksandra Barac; Isabela Bensenor; Adugnaw Berhane; Zulfiqar Bhutta; Jacqueline Castillo-Rivas; Abdulaal Chitheer; Jee-Young Choi; Benjamin Cowie; Lalit Dandona; Rakhi Dandona; Subhojit Dey; Daniel Dicker; Huyen Phuc; Donatus U. Ekwueme; Maysaa El Sayed Zaki; Florian Fischer; Thomas Fürst; Jamie Hancock; Simon I. Hay; Peter Hotez; Sun Ha Jee; Amir Kasaeian; Yousef Khader; Young-Ho Khang; Anil Kumar; Michael Kutz; Heidi Larson; Alan Lopez; Raimundas Lunevicius; Reza Malekzadeh; Colm McAlinden; Toni Meier; Walter Mendoza; Ali Mokdad; Maziar Moradi-Lakeh; Gabriele Nagel; Quyen Nguyen; Grant Nguyen; Felix Ogbo; George Patton; David M. Pereira; Farshad Pourmalek; Mostafa Qorbani; Amir Radfar; Gholamreza Roshandel; Joshua A Salomon; Juan Sanabria; Benn Sartorius; Maheswar Satpathy; Monika Sawhney; Sadaf Sepanlou; Katya Shackelford; Hirbo Shore; Jiandong Sun; Desalegn Tadese Mengistu; Roman Topór-Mądry; Bach Tran; Vasiliy Vlassov; Stein Emil Vollset; Theo Vos; Tolassa Wakayo; Elisabete Weiderpass; Andrea Werdecker; Naohiro Yonemoto; Mustafa Younis; Chuanhua Yu; Zoubida Zaidi; Liguo Zhu; Christopher J. L. Murray; Mohsen Naghavi; Christina Fitzmaurice Journal: JAMA Oncol Date: 2017-12-01 Impact factor: 31.777