Yuren Chao1, Fei Wang2, Yongbin Wang3, Bing Han4. 1. Department of Neurosurgery, The Second People Hospital of Liaocheng Liaocheng 252600, Shandong, China. 2. Department of Neurosurgery, Binzhou Traditional Chinese Medicine Hospital Binzhou 256600, Shandong, China. 3. Department of Neurosurgery, Gucheng County Hospital of Hebei Province Hengshui 253800, Hebei, China. 4. Department of Neurosurgery, The Second People's Hospital of Dongying Dongying 257335, Shandong, China.
Abstract
OBJECTIVE: To explore the correlation of serum levels of microRNA (miRNA)-124 and miRNA-210 with brain injury and inflammatory response (IR) in patients with craniocerebral injury (CI) at early stage. MATERIAL AND METHODS: Clinical data of 105 patients with CI (case group) admitted to our hospital from January 2018 to January 2020 were retrospectively analyzed. The other 60 non-CI healthy patients underwent physical examination were selected as the healthy group. The serum levels of miRNA-124 and miRNA-210 were detected by real-time fluorescence quantitative polymerase chain reaction (RT-PCR). RESULTS: The levels of serum miRNA-124 and miRNA-210 as well as the inflammatory molecules Janus kinase 2 (JAK2), signal transducer and activator of transcription 3 (STAT3), MEK, and extracellular signal-regulated kinases 1/2 (ERK1/2) in the peripheral blood of the case group were higher than those in the healthy group (P<0.05). Additionally, the serum levels of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), S100B, Tau, macrophage inflammatory protein-1α (MIP-1α), interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) in the case group were higher than those in the healthy group (P<0.05). The levels of miRNA-124 and miRNA-210 were positively correlated with the serum levels of UCH-L1, GFAP, S100B, Tau, MIP-1α, IL-1β, IL-6, and TNF-α (P<0.05) as well as with the levels of JAK2, STAT3, MEK, and ERK1/2 in the peripheral blood (P<0.05). CONCLUSION: The elevated levels of serum miRNA-124 and miRNA-210 in patients with CI are closely related to the aggravation of brain injury, overactivation of the IR, and prognosis. AJTR
OBJECTIVE: To explore the correlation of serum levels of microRNA (miRNA)-124 and miRNA-210 with brain injury and inflammatory response (IR) in patients with craniocerebral injury (CI) at early stage. MATERIAL AND METHODS: Clinical data of 105 patients with CI (case group) admitted to our hospital from January 2018 to January 2020 were retrospectively analyzed. The other 60 non-CI healthy patients underwent physical examination were selected as the healthy group. The serum levels of miRNA-124 and miRNA-210 were detected by real-time fluorescence quantitative polymerase chain reaction (RT-PCR). RESULTS: The levels of serum miRNA-124 and miRNA-210 as well as the inflammatory molecules Janus kinase 2 (JAK2), signal transducer and activator of transcription 3 (STAT3), MEK, and extracellular signal-regulated kinases 1/2 (ERK1/2) in the peripheral blood of the case group were higher than those in the healthy group (P<0.05). Additionally, the serum levels of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), S100B, Tau, macrophage inflammatory protein-1α (MIP-1α), interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) in the case group were higher than those in the healthy group (P<0.05). The levels of miRNA-124 and miRNA-210 were positively correlated with the serum levels of UCH-L1, GFAP, S100B, Tau, MIP-1α, IL-1β, IL-6, and TNF-α (P<0.05) as well as with the levels of JAK2, STAT3, MEK, and ERK1/2 in the peripheral blood (P<0.05). CONCLUSION: The elevated levels of serum miRNA-124 and miRNA-210 in patients with CI are closely related to the aggravation of brain injury, overactivation of the IR, and prognosis. AJTR
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