Literature DB >> 35173384

Molecular docking analysis of COX-2 with compounds from Piper longum.

Dhirendra Tripathi1, Sravanthi Koora2, K Satyanarayana3, S Saleem Basha4, Selvaraj Jayaraman5.   

Abstract

Piper longum (Indian long pepper) is known for its use as an anti inflammatory agent in Indian Ayurvedic System of medicine. Therefore, it is of interest to document the molecular docking analysis of compounds from Piper longum with COX-2 using the Autodock Vina PyRx tool. Molecular docking results show that asarinine, sesamine, fargesin, and piperlonguminine have optimal binding energy of 10, 10, -9.5 and 9.4 Kcal/mol, respectively for further consideration.
© 2021 Biomedical Informatics.

Entities:  

Keywords:  Anti-inflammatory compunds; COX-2; Piper longum; molecular docking

Year:  2021        PMID： 35173384      PMCID： PMC8819790          DOI： 10.6026/97320630017623

Source DB:  PubMed          Journal:  Bioinformation        ISSN： 0973-2063


  20 in total

1.  Prevalence of diabetes and prediabetes (impaired fasting glucose and/or impaired glucose tolerance) in urban and rural India: phase I results of the Indian Council of Medical Research-INdia DIABetes (ICMR-INDIAB) study.

Authors:  R M Anjana; R Pradeepa; M Deepa; M Datta; V Sudha; R Unnikrishnan; A Bhansali; S R Joshi; P P Joshi; C S Yajnik; V K Dhandhania; L M Nath; A K Das; P V Rao; S V Madhu; D K Shukla; T Kaur; M Priya; E Nirmal; S J Parvathi; S Subhashini; R Subashini; M K Ali; V Mohan
Journal:  Diabetologia       Date:  2011-09-30       Impact factor: 10.122

2.  Virtual screening of potential inhibitor against FtsZ protein from Staphylococcus aureus.

Authors:  Periyasamy Vijayalakshmi; Jaganathan Nisha; Manikkam Rajalakshmi
Journal:  Interdiscip Sci       Date:  2014-11-06       Impact factor: 2.233

3.  Endoplasmic reticulum stress-induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-kinase/Akt and increased glycogen synthase kinase-3beta in mouse insulinoma cells.

Authors:  Shanthi Srinivasan; Mitsuru Ohsugi; Zhonghao Liu; Szabolcs Fatrai; Ernesto Bernal-Mizrachi; M Alan Permutt
Journal:  Diabetes       Date:  2005-04       Impact factor: 9.461

4.  Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.

Authors:  S E Nikoulina; T P Ciaraldi; S Mudaliar; P Mohideen; L Carter; R R Henry
Journal:  Diabetes       Date:  2000-02       Impact factor: 9.461

5.  Effective interaction studies for inhibition of DNA ligase protein from Staphylococcus aureus.

Authors:  Periyasamy Vijayalakshmi; Pitchai Daisy
Journal:  J Recept Signal Transduct Res       Date:  2014-07-23       Impact factor: 2.092

6.  AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility.

Authors:  Garrett M Morris; Ruth Huey; William Lindstrom; Michel F Sanner; Richard K Belew; David S Goodsell; Arthur J Olson
Journal:  J Comput Chem       Date:  2009-12       Impact factor: 3.376

Review 7.  PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?

Authors:  M A Lawlor; D R Alessi
Journal:  J Cell Sci       Date:  2001-08       Impact factor: 5.285

Review 8.  A comprehensive review on pharmacotherapeutics of herbal bioenhancers.

Authors:  Ghanshyam B Dudhatra; Shailesh K Mody; Madhavi M Awale; Hitesh B Patel; Chirag M Modi; Avinash Kumar; Divyesh R Kamani; Bhavesh N Chauhan
Journal:  ScientificWorldJournal       Date:  2012-09-17

9.  Paederia foetida Linn. leaf extract: an antihyperlipidemic, antihyperglycaemic and antioxidant activity.

Authors:  Vikas Kumar; Firoz Anwar; Danish Ahmed; Amita Verma; Aftab Ahmed; Zoheir A Damanhouri; Vatsala Mishra; Pramod W Ramteke; Prakash Chandra Bhatt; Mohd Mujeeb
Journal:  BMC Complement Altern Med       Date:  2014-02-25       Impact factor: 3.659

10.  PubChem Substance and Compound databases.

Authors:  Sunghwan Kim; Paul A Thiessen; Evan E Bolton; Jie Chen; Gang Fu; Asta Gindulyte; Lianyi Han; Jane He; Siqian He; Benjamin A Shoemaker; Jiyao Wang; Bo Yu; Jian Zhang; Stephen H Bryant
Journal:  Nucleic Acids Res       Date:  2015-09-22       Impact factor: 16.971
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.