Literature DB >> 3517323

Human articular cartilage secretes characteristic metal dependent proteinases upon stimulation by mononuclear cell factor.

I K Campbell, E E Golds, J S Mort, P J Roughley.   

Abstract

Human articular cartilage stimulated during organ culture by the addition of human blood mononuclear cell factor concomitantly released latent proteinases and proteoglycan. Gel chromatography at pH 7.4 separated 2 distinct latent enzymes: a general proteinase which could degrade proteoglycan, casein and gelatin, and a collagenolytic activity of smaller molecular size. The general proteinase was calcium dependent and could be activated by either trypsin or 4-aminophenylmercuric acetate; the former procedure invariably generating greatest activity. The enzyme exhibited a broad bimodal pH profile against proteoglycan, with optimum activity at pH 5.5.

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Year:  1986        PMID： 3517323

Source DB:  PubMed          Journal:  J Rheumatol        ISSN： 0315-162X            Impact factor:   4.666


  11 in total

1.  Inflammatory cytokines induce synthesis and secretion of gro protein and a neutrophil chemotactic factor but not beta 2-microglobulin in human synovial cells and fibroblasts.

Authors:  E E Golds; P Mason; P Nyirkos
Journal:  Biochem J       Date:  1989-04-15       Impact factor: 3.857

2.  Link protein as a monitor in situ of endogenous proteolysis in adult human articular cartilage.

Authors:  Q Nguyen; J Liu; P J Roughley; J S Mort
Journal:  Biochem J       Date:  1991-08-15       Impact factor: 3.857

3.  Degradation of proteoglycan aggregate by a cartilage metalloproteinase. Evidence for the involvement of stromelysin in the generation of link protein heterogeneity in situ.

Authors:  Q Nguyen; G Murphy; P J Roughley; J S Mort
Journal:  Biochem J       Date:  1989-04-01       Impact factor: 3.857

4.  Coculture of human articular chondrocytes with peripheral blood mononuclear cells as a model to study cytokine-mediated interactions between inflammatory cells and target cells in the rheumatoid joint.

Authors:  A M Malfait; G Verbruggen; K F Almqvist; C Broddelez; E M Veys
Journal:  In Vitro Cell Dev Biol Anim       Date:  1994-11       Impact factor: 2.416

5.  Effects of antirheumatic drugs on the interleukin-1 alpha induced synthesis and activation of proteinases in articular cartilage explants in culture.

Authors:  C Arsenis; J McDonnell
Journal:  Agents Actions       Date:  1989-06

6.  Effects of murine recombinant interleukin 1 on intact homologous articular cartilage: a quantitative and autoradiographic study.

Authors:  W B van den Berg; F A van de Loo; W A Zwarts; I G Otterness
Journal:  Ann Rheum Dis       Date:  1988-10       Impact factor: 19.103

7.  The action of human articular-cartilage metalloproteinase on proteoglycan and link protein. Similarities between products of degradation in situ and in vitro.

Authors:  I K Campbell; P J Roughley; J S Mort
Journal:  Biochem J       Date:  1986-07-01       Impact factor: 3.857

8.  Purification of the neutral proteoglycan-degrading metalloproteinase from human articular cartilage tissue and its identification as stromelysin matrix metalloproteinase-3.

Authors:  Z Gunja-Smith; H Nagase; J F Woessner
Journal:  Biochem J       Date:  1989-02-15       Impact factor: 3.857

9.  Agalactosyl glycoforms of IgG autoantibodies are pathogenic.

Authors:  T W Rademacher; P Williams; R A Dwek
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-21       Impact factor: 11.205

10.  Immunity to the G1 globular domain of the cartilage proteoglycan aggrecan can induce inflammatory erosive polyarthritis and spondylitis in BALB/c mice but immunity to G1 is inhibited by covalently bound keratan sulfate in vitro and in vivo.

Authors:  J Y Leroux; A Guerassimov; A Cartman; N Delaunay; C Webber; L C Rosenberg; S Banerjee; A R Poole
Journal:  J Clin Invest       Date:  1996-02-01       Impact factor: 14.808
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