| Literature DB >> 35165865 |
Defne Bayik1,2, Juyeun Lee1, Justin D Lathia3,4.
Abstract
Myeloid-derived suppressor cells (MDSCs) are immature bone marrow-derived suppressive cells that are an important component of the pathological immune response associated with cancer. Expansion of MDSCs has been linked to poor disease outcome and therapeutic resistance in patients with various malignancies, making these cells potential targets for next-generation treatment strategies. MDSCs are classified into monocytic (M-MDSC) and polymorphonuclear/granulocytic (PMN-MDSC) subtypes that undertake distinct and numerous roles in the tumor microenvironment or systemically to drive disease progression. In this chapter, we will discuss how MDSC subsets contribute to the growth of primary tumors and induce metastatic spread by suppressing the antitumor immune response, supporting cancer stem cell (CSC)/epithelial-to-mesenchymal transition (EMT) phenotypes and promoting angiogenesis. We will also summarize the signaling networks involved in the crosstalk between cancer cells and MDSCs that could represent putative immunotherapy targets.Entities:
Keywords: Granulocytic (G-MDSC); Immunosuppression; Inflammation; Metastasis; Monocytic (M-MDSC); Myeloid-derived suppressor cells (MDSCs); Polymorphonuclear (PMN-MDSC); Tumorigenesis
Mesh：
Year: 2022 PMID： 35165865 DOI： 10.1007/978-3-030-91311-3_7
Source DB: PubMed Journal: Exp Suppl ISSN： 1664-431X