| Literature DB >> 35158302 |
Ilaria Scambi1, Daniele Peroni2, Alice Nodari1, Flavia Merigo1, Donatella Benati1, Federico Boschi3, Silvia Mannucci1, Andrea Frontini4, Silvia Visonà5, Andrea Sbarbati1, Mauro Krampera6, Mirco Galiè7.
Abstract
Multipotent stem cells persist within the stromal vascular fraction (SVF) of adipose tissue during adulthood. These cells, commonly referred to as adipose-derived stromal cells (ASC), have been extensively investigated over the past years as a promising therapeutic tool based on their regenerative and immunomodulatory properties. However, how ASC might mirror the age-related alteration of the fat they reside in remains unclear. Herein, we show that inguinal adipose tissue in mice turns from brown/beige- to white-like with age and resident ASC readily mirror these changes both at mRNA and microRNA transcriptional level. Mechanistically, our data suggest that these brown/age-related changes in ASC transcription rely on changes in the activity of E2F1 and NFkB transcription factors.Entities:
Keywords: Adipose tissue; Adipose-derived stromal cells; Aging; Beige adipocyte; White adipocyte; microRNA
Mesh：
Year: 2022 PMID： 35158302 DOI： 10.1016/j.ejcb.2022.151206
Source DB: PubMed Journal: Eur J Cell Biol ISSN： 0171-9335 Impact factor: 4.492