Babak Arjmand1, Mahmood Khodadoost2, Somayeh Jahani Sherafat3, Mostafa Rezaei Tavirani4, Nayebali Ahmadi4, Maryam Hamzeloo Moghadam5, Farshad Okhovatian6, Sina Rezaei Tavirani7. 1. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. 2. School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 3. Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 4. Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 5. Traditional Medicine and Materia Medica Research Center, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 6. Physiotherapy Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 7. Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract
Introduction: One of the chemoradiotherapy (CRT) side effects is oral mucositis (OM). Since photobiomodulation therapy (PBMT) is a public method for the repair process, in the present study the mechanism of PBMT in the prevention of OM is investigated via the bioinformatics approach. Methods: Six validated and significant differentially expressed genes (DEGs) associated with the prevention of OM in head and neck cancer (HNC) patients who had experienced CRT were extracted from the literature. After adding 50 neighbors from STRING, the network was constructed and analyzed. The results of the action map and network analysis were compared and discussed. Results: HLA gene family were identified as central nodes of the analyzed network. Based on action map finding, activation is prominent action and IRF9 was the potent activator. The role of the IRF gene family was highlighted by action map analysis. Conclusion: Regulation of the immune system by HLA and IRF genes family is a crucial factor in the prevention of OM in the studied patients.
Introduction: One of the chemoradiotherapy (CRT) side effects is oral mucositis (OM). Since photobiomodulation therapy (PBMT) is a public method for the repair process, in the present study the mechanism of PBMT in the prevention of OM is investigated via the bioinformatics approach. Methods: Six validated and significant differentially expressed genes (DEGs) associated with the prevention of OM in head and neck cancer (HNC) patients who had experienced CRT were extracted from the literature. After adding 50 neighbors from STRING, the network was constructed and analyzed. The results of the action map and network analysis were compared and discussed. Results: HLA gene family were identified as central nodes of the analyzed network. Based on action map finding, activation is prominent action and IRF9 was the potent activator. The role of the IRF gene family was highlighted by action map analysis. Conclusion: Regulation of the immune system by HLA and IRF genes family is a crucial factor in the prevention of OM in the studied patients.
Authors: Johannes A Langendijk; Philippe Lambin; Dirk De Ruysscher; Joachim Widder; Mike Bos; Marcel Verheij Journal: Radiother Oncol Date: 2013-06-05 Impact factor: 6.280
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Authors: Heliton S Antunes; Gabriel Wajnberg; Marcos B Pinho; Natasha Andressa Nogueira Jorge; Joyce Luana Melo de Moraes; Claudio Gustavo Stefanoff; Daniel Herchenhorn; Carlos M M Araújo; Celia Maria Pais Viégas; Mariana P Rampini; Fernando L Dias; Patricia Savio de Araujo-Souza; Fabio Passetti; Carlos G Ferreira Journal: Lasers Med Sci Date: 2017-08-24 Impact factor: 3.161