Literature DB >> 35152350

UBC9 inhibits myeloid differentiation in collaboration with AML1-MTG8.

Tomofusa Fukuyama1,2, Toshio Kitamura3, Tomoko Kozu4.   

Abstract

The chimeric oncogene AML1-MTG8 (RUNX1-RUNX1T1) is generated in t(8;21) acute myeloid leukemia (AML). Here, we report a novel interaction of MTG8/RUNX1T1/ETO with UBC9/UBE2I. AML1-MTG8 protein also interacted with UBC9, suggesting a role in leukemogenesis. Overexpression of UBC9 in Kasumi-1 attenuated myeloid differentiation induced by all-trans retinoic acid, G-CSF, and GM-CSF (AGGM), which was judged by suppression of CD11b. In addition, the UBC9 inhibitor 2-D08 accelerated myeloid differentiation induced by AGGM in two t(8;21) AML cell lines, Kasumi-1 and SKNO-1. These data suggest that UBC9 may play a role in leukemogenesis in t(8;21) AML by working with AML1-MTG8 to suppress myeloid differentiation. Therefore, UBC9 may be a good target for new differentiation therapy against t(8;21) AML.
© 2022. Japanese Society of Hematology.

Entities:  

Keywords:  AML1; ETO; MTG8; RUNX1; UBC9

Mesh：

Substances：

Year:  2022        PMID： 35152350     DOI： 10.1007/s12185-022-03303-1

Source DB:  PubMed          Journal:  Int J Hematol        ISSN： 0925-5710            Impact factor:   2.490


  47 in total

1.  Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt.

Authors:  P Erickson; J Gao; K S Chang; T Look; E Whisenant; S Raimondi; R Lasher; J Trujillo; J Rowley; H Drabkin
Journal:  Blood       Date:  1992-10-01       Impact factor: 22.113

2.  The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family.

Authors:  T Gamou; E Kitamura; F Hosoda; K Shimizu; K Shinohara; Y Hayashi; T Nagase; Y Yokoyama; M Ohki
Journal:  Blood       Date:  1998-06-01       Impact factor: 22.113

Review 3.  Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel.

Authors:  Hartmut Döhner; Elihu Estey; David Grimwade; Sergio Amadori; Frederick R Appelbaum; Thomas Büchner; Hervé Dombret; Benjamin L Ebert; Pierre Fenaux; Richard A Larson; Ross L Levine; Francesco Lo-Coco; Tomoki Naoe; Dietger Niederwieser; Gert J Ossenkoppele; Miguel Sanz; Jorge Sierra; Martin S Tallman; Hwei-Fang Tien; Andrew H Wei; Bob Löwenberg; Clara D Bloomfield
Journal:  Blood       Date:  2016-11-28       Impact factor: 22.113

4.  The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1.

Authors:  I Kitabayashi; K Ida; F Morohoshi; A Yokoyama; N Mitsuhashi; K Shimizu; N Nomura; Y Hayashi; M Ohki
Journal:  Mol Cell Biol       Date:  1998-02       Impact factor: 4.272

Review 5.  Oncogenic transcription factors in the human acute leukemias.

Authors:  A T Look
Journal:  Science       Date:  1997-11-07       Impact factor: 47.728

6.  Clinical Impact of Additional Cytogenetic Aberrations, cKIT and RAS Mutations, and Treatment Elements in Pediatric t(8;21)-AML: Results From an International Retrospective Study by the International Berlin-Frankfurt-Münster Study Group.

Authors:  Kim Klein; Gertjan Kaspers; Christine J Harrison; H Berna Beverloo; Ardine Reedijk; Mathilda Bongers; Jacqueline Cloos; Andrea Pession; Dirk Reinhardt; Martin Zimmerman; Ursula Creutzig; Michael Dworzak; Todd Alonzo; Donna Johnston; Betsy Hirsch; Michal Zapotocky; Barbara De Moerloose; Alcira Fynn; Vincent Lee; Takashi Taga; Akio Tawa; Anne Auvrignon; Bernward Zeller; Erik Forestier; Carmen Salgado; Walentyna Balwierz; Alexander Popa; Jeffrey Rubnitz; Susana Raimondi; Brenda Gibson
Journal:  J Clin Oncol       Date:  2015-11-16       Impact factor: 44.544

7.  Junctions of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction.

Authors:  T Kozu; H Miyoshi; K Shimizu; N Maseki; Y Kaneko; H Asou; N Kamada; M Ohki
Journal:  Blood       Date:  1993-08-15       Impact factor: 22.113

8.  EHT, a new member of the MTG8/ETO gene family, maps on 20q11 region and is deleted in acute myeloid leukemias.

Authors:  N S Fracchiolla; G Colombo; P Finelli; A T Maiolo; A Neri
Journal:  Blood       Date:  1998-11-01       Impact factor: 22.113

9.  Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells.

Authors:  P E Nisson; P C Watkins; N Sacchi
Journal:  Cancer Genet Cytogenet       Date:  1992-10-15

10.  The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript.

Authors:  H Miyoshi; T Kozu; K Shimizu; K Enomoto; N Maseki; Y Kaneko; N Kamada; M Ohki
Journal:  EMBO J       Date:  1993-07       Impact factor: 11.598
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.