Literature DB >> 35150096

Clinical Images: Giant mass on the forehead in Kimura disease.

Tomohiro Yoshida1, Keisuke Nishimura1, Daisuke Waki1, Nozomi Tanaka1, Hiroyuki Murabe1, Toshihiko Yokota1.   

Abstract

Entities:  

Year:  2022        PMID: 35150096      PMCID: PMC9274332          DOI: 10.1002/acr2.11419

Source DB:  PubMed          Journal:  ACR Open Rheumatol        ISSN: 2578-5745


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The patient, a 68‐year‐old Asian man with a history of nephrotic syndrome, presented to our department with multiple subcutaneous masses that developed over the past 50 years. The masses were painless, soft, and predominantly located in the head. The mass on the forehead was dome‐shaped and had a diameter of 7 cm and a height of 3 cm (A). Blood tests showed eosinophilia and elevated immunoglobulin E (IgE) levels. Serum immunoglobulin G4 levels were normal. Ultrasonography showed heterogeneous masses with marked associated internal hyperemia (B). Magnetic resonance imaging showed T1‐weighted isointense and T2‐weighted hyperintense masses. A needle biopsy of the forehead mass showed stromal fibrosis, multiple lymphoid follicles, and infiltration of inflammatory cells, mainly eosinophils and lymphocytes. The patient was diagnosed with Kimura disease (KD). The masses shrank rapidly after administration of 30 mg/day of prednisolone for 2 weeks. KD is a rare chronic inflammatory disorder mainly affecting young Asian men. It presents as subcutaneous masses, typically in the head and neck, and is associated with eosinophilia and elevated IgE levels (1). It often affects the cervical lymph nodes and salivary glands (1). It is often associated with renal involvement, such as nephrotic syndrome (2). Glucocorticoids, surgical excision, and radiation therapy are the treatments of choice (3). The diagnosis of KD can be difficult because of its rarity. KD should be considered as a differential diagnosis when patients present with painless subcutaneous masses in the head and neck region with eosinophilia and elevated serum IgE levels. Disclosureform: Click here for additional data file.
  3 in total

Review 1.  Comparison of Local Recurrence Rate of Three Treatment Modalities for Kimura Disease.

Authors:  Peng Ye; Tai Wei; Guang-Yan Yu; Li-Ling Wu; Xin Peng
Journal:  J Craniofac Surg       Date:  2016-01       Impact factor: 1.046

2.  The clinicopathological characteristics of Kimura disease in Chinese patients.

Authors:  Xuehan Zhang; Yang Jiao
Journal:  Clin Rheumatol       Date:  2019-08-22       Impact factor: 2.980

Review 3.  Kimura disease: a case report and review of the Chinese literature.

Authors:  D Y Wang; J H Mao; Y Zhang; W Z Gu; S A Zhao; Y F Chen; A M Liu
Journal:  Nephron Clin Pract       Date:  2008-12-03
  3 in total

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